Is oral lornoxicam effective in the treatment of acute migraine attacks? : a randomized-controlled study

The aim of this study was to assess the efficacy of lornoxicam (LNX) in the treatment of acute migraine attacks. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial was conducted administering either LNX or placebo to patients who were diagnosed with migraine without aura according to the International Headache Society (the year 2004) criteria between 2010 and 2012 Results: Of 44 patients with 120 migraine attacks, 38 were female and rest were males. Mean age was 37.75 ± 9.28 years. Patients recorded using LNX in 87 migraine attacks and placebo in 33 migraine attacks, respectively. Pain intensity scores of the patients were found similar between LNX and placebo groups, statistically. Conclusion: Although oral LNX was found to have efficacy similar to placebo statistically in the treatment of acute migraine attacks, further studies are needed to evaluate appropriately the efficacy of LNX for treatment of acute migraine attacks

Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) is still a poorly understood disorder which pathophysiological mechanisms include the autonomic, sensory and motor systems as well as cortical areas involved in the processing of cognitive and affective information. The main CRPS clinical symptoms are pain and hyperalgesia, vasomotor, sudomotor and trophic changes in the affected extremity. In addition, motor symptoms are usually present from the beginning, and may progress with ongoing duration. CRPS patients exhibit changes that occur in somatosensory systems processing noxious, tactile and thermal information, in sympathetic systems innervating skin (blood vessels, sweat glands) and in the somatomotor system. The most common approach to the treatment of CRPS combines sequential trials of analgesic drugs with rehabilitative and psychological interventions. Invasive techniques like sympathetic blocks, spinal cord stimulation, etc. have limited roles in CRPS. (Archives of Neuropsychiatry 2009; 46: 70-5

Palliative Care in Lung Cancer

The Lung cancer rate in all cancer types is 21% in men and 5 % in women in European Union Countries. Smoking is the most important factor of lung cancer etiology [1]. The rate of Turkey is found 63% in men and 14% in women in 1988. 88.7% of the patients in Turkey have got smoking story. Lung cancer risk increases 3.5 times in passive smoking. Because there are carcinogens in air and they are not filtered; therefore, they are denser on air [2]

Craniocervical Pains

Craniocervical pains can be analyzed in two groups: cranial neuralgias and cervicogenic pains. Cranial neuralgias are with neuropathic character; however, their etiologies might be atypical, idiopathic and psychogenic. Generally, it can be experienced as one-sided lightning strikes, electric shock-like and stabbing pain. The paroxysmal pains originate from nerves with somatic afferent fibers, such as trigeminal, facial, glossopharingeal, vagus, and also sometimes from the C2-3 dorsal roots. Moreover, the most commonly seen are trigeminal neuralgias. Cervicogenic pains are caused by cervical spinal nerves, pathologies of the structure of the cervical intervertebral disc, cervical facet joints and the soft tissue of these areas. Turk J Phys Med Rehab 2010;56 Suppl 1:38-45

Comparison of efficacy of intraarticular application of magnesium, levobupivacaine and lornoxicam with placebo in arthroscopic surgery

Purpose Arthroscopic knee surgery is done in outpatient settings; however, postoperative pain is a major barrier for discharge and limits early rehabilitation. The efficacy of intraarticular application of magnesium sulphate, levobupivacaine and lornoxicam, with placebo on postoperative pain after arthroscopic meniscectomy was evaluated

Efficacy of quick-release lornoxicam versus placebo for acute pain management after dental implant surgery: a randomised placebo-controlled triple-blind trial

Aim: To assess the efficacy of quick-release lornoxicam (LNX) on patient-reported acute pain after dental implant surgery

The Efficacy of Preemptive Ketamine and Ropivacaine in Pediatric Patients: A Placebo Controlled, Double-blind

OBJECTIVE: We have evaluated and compared the preemptive efficacy of intravenous ketamine with placebo and caudal ropivacaine in pediatric patients going under elective hernia repair

Comparison of analgesic activity of intraarticular lornoxicam, bupivacaine and saline after knee arthroscopy

Postoperative pain is an important parameter in discharge and rehabilitation in daycase arthroscopic knee surgery. This study compared the efficacy of intraarticular application of lornoxicam, bupivacaine and placebo on postoperative pain after arthroscopic knee surgery. With the approval of the local ethics committee and informed consent of the patients, 90 patients (ASA score I-II), aged between 18-65 years undergoing arthroscopic meniscectomy were included in this randomized, blinded, prospective study and were divided into three groups (30 patients each): 8 mg lornoxicam was applied to Group L (GL), 50 mg bupivacaine to Group B (GB) and normal saline to Group S (GS) in 20 mL volume intraarticularly. Postoperative analgesia was maintained by intravenous tramadol-HCl 50 mg/h at the first 4 h and then paracetamol 500 mg plus codeine 7.5 mg preparation as needed. The numeric rating scale (NRS) values were evaluated at rest and at active-passive motion at 4, 12, 24 and 48 h, total analgesic consumption were recorded. There were statistically significant differences between GS and GL and GS and GB in term of tramadol consumption (p<0.05 and p<0.05). The analgesiconsumption of GL patients at the end of 48 h were lower than GB and GS (p<0.001 and p<0.05). The NRS values of GL were always lower than the other groups with statistical significance at certain times. We concluded that intraarticular lornoxicam provided better pain control than bupivacaine and saline in arthroscopic knee surgery

Perioperative dexketoprofen or lornoxicam administration for pain management after major orthopedic surgery: a randomized, controlled study

Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended for multimodal postoperative pain management. The purpose of this study was to evaluate the postoperative pain relief and opioid-sparing effects of dexketoprofen and lornoxicam after major orthopedic surgery