58 research outputs found
SpororastuÄi osteosarkom lopatice u psa mops pasmine - prikaz sluÄaja
A scapular bone tumor in a 7-year-old male Pug is described. The Pug accidentally ran into a door six years before and started to limp on his front right leg. A small mass was noticed by the Pugās owners on his right shoulder which was ignored by the veterinarian. The mass increased in size until it became 9 cm in diameter and the dog was not using his leg occasionally. Finally the dog was referred to the Surgery, Ophthalmology and Orthopedics Clinic for further diagnostics. Following complete clinical and orthopedic examinations, an X-ray of the right scapula was performed and a neoplasia of the scapulae was suspected. A biopsy and histopathological examination was recommended in order to rule out osteosarcoma. The histopathological examination established the diagnosis of a highly productive, osteoblastic osteosarcoma of the right scapula with pulmonary metastasis. Prognosis was unfavorable due to metastases to the lungs evidenced by the X-ray. We report a case concerning an untreated scapular neoplasia with X-ray detectable lung metastases upon presentation at the Clinic. Proper diagnosis should be based on clinical examination, radiograph evaluation of the process and histopathological findings after bone biopsy. Blunt trauma can be a trigger for development of slow growing periosteal osteosarcoma, as described here. Treatment often include subtotal scapulectomy or forequarter amputation with adjuvant chemotherapy. Despite aggressive treatment, scapular osteosarcoma has a poor prognosis with low median survival time and disease free interval in dogs. Unfortunately the Pugās owners refused the recommended treatment and the dog was euthanized 2 months later.Opisan je tumor lopatice u sedmogodiÅ”njega muÅ”kog mopsa. Kao Å”tene, sluÄajno je naletio na vrata i poÄeo Å”epati na prednju desnu nogu. Vlasnici su primijetili malu tvorbu, oteklinu na desnoj lopatici koju je veterinar ignorirao. Tvorba se s godinama poveÄavala do veliÄine od 9 cm u promjeru, a pas je povremeno Å”epao. Nakon kliniÄkog i ortopedskog pregleda te rendgenografskog oslikavanja desne lopatice posumnjalo se na neoplaziju lopatice. PreporuÄena je biopsija i histopatoloÅ”ka pretraga tvorbe kako bi se potvrdila sumnja na osteosarkom. HistopatoloÅ”ki nalaz upuÄivao je na vrlo produktivan, osteoblastiÄni osteosarkom desne lopatice s pluÄnim metastazama. Prognoza je bila nepovoljna zbog rendgenografski dokazanih metastaza na pluÄima Kao Å”to je ovdje opisano, trauma može biti okidaÄ za razvoj spororastuÄeg periostalnog osteosarcoma, a pravilno dijagnosticiranje treba temeljiti na kliniÄkom pregledu, rendgenografskoj procjeni procesa i histopatoloÅ”kom nalazu. LijeÄenje osteosarkoma lopatice Äesto ukljuÄuje potpunu skapulektomiju ili amputaciju prednje noge s odgovarajuÄom kemoterapijom. UnatoÄ agresivnom lijeÄenju, skapularni osteosarkom ima loÅ”u prognozu, s niskim srednjim vremenom preživljenja i kratkim razdobljem bez bolesti u pasa. Nažalost, vlasnici mopsa odbili su preporuÄeno lijeÄenje i pas je nakon dva mjeseca eutanaziran
Usporedba standardne perinealne herniorafije i transpozicije unutarnjega opturatornog miÅ”iÄa u lijeÄenju perinealne hernije pasa.
Forty male dogs underwent 46 perineal herniorrhaphy procedures. In 22 dogs, herniorrhaphy was
performed by standard perineal herniorrhaphy and in 18 dogs by internal obturator muscle transposition (six bilateral herniorrhaphies). Castration was performed in 13 (59%) dogs operated by standard perineal herniorrhaphy and in 14 (77%) dogs operated by transposition of the internal obturator muscle. Rectal disease was preoperatively observed in 22 (46%) cases. Recurrence was recorded in six (27%) dogs operated by standard perineal herniorrhaphy and in two (11%) dogs operated by internal obturator muscle transposition. Postoperative complications developed in 30 (65%) cases. The most common complications were wound complications (swelling, seroma, dehiscence and hematoma), lameness and tenesmus. Study results indicated the method of internal obturator muscle transposition to create a stronger perineal diaphragm with a lower
incidence of recurrence compared to standard perineal herniorrhaphy.Operirano je 40 muÅ”kih pasa u 46 operacijskih zahvata. Standardna perinealna herniorafija uÄinjena je u 22 psa, a transpozicija unutarnjega opturatornog miÅ”iÄa u 18 pasa (Å”est obostranih perinealnih hernija). Kastrirano je 13 (59%) pasa operiranih standardnom perinealnom herniorafijom te 14 (77%) pasa operiranih transpozicijom unutarnjega opturatornog miÅ”iÄa. Promjene na rektumu uoÄene su u 22 (48%) psa prije operacije. Å est (27%) pasa operiranih standardnom metodom imalo je recidiv, dok je isti uoÄen tek u dva (11%) psa operirana transpozicijom unutarnjega opturatornog miÅ”iÄa. Za vrijeme poslijeoperacijskog praÄenja komplikacije su uoÄene u 30 (65%) pasa. NajÄeÅ”Äe uoÄene komplikacije bile su komplikacije rane (oteklina, serom, dehiscencija i hematom), hromost i napinjanje. Rezultati ovog istraživanja pokazuju da je metoda transpozicije unutarnjega opturatornog miÅ”iÄa bolja, jer dovodi do nastanka ÄvrÅ”Äe perinealne dijafragme s manjim postotkom recidiviranja
Diagnostic and surgical treatment of medial patellar luxation in dogs
Medijalno iÅ”ÄaÅ”enje ivera Äesta je pojava i uzrok Å”epanja u malih pasmina pasa te ima veliko znaÄenje u veterinarskoj praksi. MeÄutim, kirurÅ”ko lijeÄenje lakÅ”ih sluÄajeva, osobito I stupnja Äesto se izbjegava i ne smatra bitnim. Konzervativno lijeÄenje ne daje zadovoljavajuÄe rezultate. IÅ”ÄaÅ”enje može nastati zbog traume, ali može biti prisutno veÄ pri roÄenju Å”to je Äesto povezano s težim deformacijama kostiju. Nasljednog je karaktera. Težina kliniÄkih znakova ovisi o stupnju iÅ”ÄaÅ”enja ivera, a u nekim sluÄajevima kada nema kliniÄkih znakova do dijagnoze se dolazi tijekom rutinskog kliniÄkog pregleda. Osim ortopedskog pregleda, dijagnoza se postavlja na temelju rendgenskog snimanja koje može biti negativno u I ili Äak II stupnju iÅ”ÄaÅ”enja. Vrsta operativnog zahvata ovisi o stupnju iÅ”ÄaÅ”enja, a može se temeljiti na rekonstrukciji mekih tkiva ili kostiju. NajÄeÅ”Äe koriÅ”tene tehnike su zatezanje lateralnog retinakuluma s otpuÅ”tanjem medijalnog retinakuluma, produbljivanje trohlearnog kanala, odnosno trohleoplastike i premjeÅ”tanja goljeniÄne kvrge lateralno i Äak blago distalno. Kod težih deformacija kostiju primjenjuje se korektivna osteotomija bedrene kosti. Danas postoje i moderne metode lijeÄenja ovog ortopedskog problema kao Å”to je koriÅ”tenje implantanata ili endoproteza koje poveÄavaju ili u potpunosti zamjenjuju trohlearni žlijeb. Ove tehnike imaju znatno viÅ”u cijenu. Veliku ulogu u lijeÄenju treba dati i postoperativnoj analgeziji te imobilizaciji noge. RjeÄe se dogaÄaju veÄe komplikacije, ali se može javiti ponovno iÅ”ÄaÅ”enje ivera, popuÅ”tanje implantanata Å”to se smatra najÄeÅ”Äim te lom goljeniÄke kvrge kao najteža komplikacija. U veÄini sluÄajeva prognoza je odliÄna, noga se vraÄa normalnoj funkciji, a hromost se ne pojavljuje. Ovaj rad ukratko opisuje kliniÄku sliku, dijagnostiÄke metode i kirurÅ”ko lijeÄenje medijalnog iÅ”ÄaÅ”enja ivera u pasa uz osvrt na suvremene kirurÅ”ke metode.Medial patellar luxation is a common occurrence and the cause of lameness in small dog breeds, and therefore of great significance in veterinary practice. However, surgical treatment of light cases, such as grade I is often avoided and not considered essential. In most cases, conservative treatment is insufficient. Luxations can occure due to trauma or can be present at birth, which is often associated with more severe bone deformations. It is hereditary disease. The severity of clinical signs depends on the degree of patellar luxation, though there may be no clinical signs until diagnosis is made during routine clinical examination. Apart from an orthopaedic examination, the diagnosis is set after radiography which can be negative in grade I or even grade II. The type of surgery depends on the degree of luxation and may be based on soft tissue or bone reconstruction. The most commonly used techniques are overlap of the lateral retinaculum, medial retinaculum release, trochleoplasty and transposition of tibial tuberosity laterally or distally. In severe bone deformations, osteotomy of the femur is applied. There are now modern methods to treat this orthopaedic problem, such as the use of endoprosthetic implants that enhance or substitute the patellar grove completely. An important role in treatment should be given to postoperative analgesia and leg immobilization. There are fewer complications, though there may be a recurrence of patellar luxation and loosening of implants, as the most common complication, or tibial crest fractures as the most severe complication. In most cases, the prognosis is excellent, the leg returns to normal function and lameness does not appear. This paper describes the clinical signs, diagnostic procedures and surgical treatment of medial patellar luxation in dogs with several of the mentioned modern
techniques
Denzitometrija mineralizacije kalusa u kritiÄnom defektu kuniÄje palÄane kosti
This study aims to investigate the use of a photodensitometry to analyze plain radiographic images and correlate them with the rate of new bone formation in a critical size defect of a rabbit radius filled with an autologous omental graft. The computer program MCID Evaluation 7.0. was used for photodensitometric processing of X-ray images taken at 2, 4, 6 and 8 weeks after surgery. The study was conducted on 20 adult New Zealand white rabbits under general anaesthesia, critical-sized osseous defect was created in the right radius and in treated group filled with autogenous omental graft. Optical densitometry of radiographs revealed statistically significant differences between the experimental and control sites. The study showed that autogenous omental grafts promoted healing of the critical-sized defect of the rabbit radius.Istražena je upotreba fotodenzitometrije za analizu rendgenograma u usporedbi sa stopom novostvorene kosti u kritiÄnom defektu kuniÄje palÄane kosti ispunjene autolognim presatkom velikoga omentuma. RaÄunalni program MCID 7.0. rabljen je za obradu rengenograma koji su snimljeni 2, 4, 6 i 8 tjedana nakon operacije. Istraživanje je provedeno na 20 odraslih novozelandskih kuniÄa u opÄoj anesteziji. Denzitometrija rendgenograma pokazala je statistiÄki znaÄajne razlike izmeÄu pokusne i kontrolne skupine. Istraživanje je pokazalo da autologni presadak omentuma pospjeÅ”uje cijeljenje kritiÄnoga defekta kuniÄje palÄane kosti
Comparison of feline odontoclastic resorptive lesions with caries in humans - similarities and differences
U ovom radu dana je usporedba odontoklastiÄne resorptivne lezije u maÄaka (FORL) s humanim karijesom, kao dvije najÄeÅ”Äe dijagnosticirane bolesti u usnoj Å”upljini ovih dviju vrsta. FORL najÄeÅ”Äa je bolest zuba u felida Å”to prouzroÄi bol, gingivalnu upalu, uniÅ”tavanje parodontnog veziva i gubitka zuba. Progresivna je bolest te je jedini tretman ekstrakcija zuba. KliniÄki se oÄituje hiperplastiÄnom ili hiperemiÄnom gingivom, a lezije su najÄeÅ”Äe locirane na podruÄju premolara vrata zuba te se nazivaju vratnim lezijama. SpecifiÄne promjene koje se javljaju kod FORL-a su hipercementoza koja prouzroÄi gomoljast oblik vrha korijena, supererupcija, zadebljanja kosti duž alveolarne granice ili povrÅ”ine alveolarnih ploÄa. Simptomi su hipersalivacija i bolnost u podruÄju Äeljusti gdje su oboljeli zubi i bolnost zuba zbog otvorenog pulpinog kanala. Karijes je po uÄestalosti druga bolest ÄovjeÄanstva te obiÄno zapoÄinje na mjestima gdje se najviÅ”e nakupljaju ostatci hrane te se oblikuje zubni plak, a to su fisure zuba, plohe izmeÄu zuba i vratni dijelovi zubne krune. Simptomi mogu ukljuÄivati poteÅ”koÄe s prehranom i bol, a komplikacije koje se mogu javiti su upala gingive, infekcija ili apsces te gubitak zuba. Inicijalna karijesna lezija obiÄno zapoÄinje kao proces demineralizacije na glatkim plohama, a prikazuje se kao bijelo zamuÄenje, odnosno bijela mrlja. SpecifiÄne promjene koje se javljaju kod karijesa su tubulusna skleroza, odgovor pulpe na razliÄite stadije razvoja karijesa u obliku tercijarnog dentina te recesija gingive. Karijes se lijeÄi konzervativno ili operativno. Iz svega navedenoga se može zakljuÄiti da se FORL i karijes razliku po simptomima, etiologiji i terapiji, a najbitnija je razlika histopatoloÅ”ka.In this review article, feline odontoclastic resorptive lesion (FORL) was compared with human caries as the most commonly diagnosed disease in the oral cavity of both species. FORL is the most common disease of teeth in felines and causes pain, gingival inflammation, destruction of periodontal tissue and tooth loss. FORL is a progressive disease and the only treatment is tooth extraction. It is clinically manifested by hyperplastic or hyperemic gingivitis, and the lesions are usually located in the area of the neck of the tooth and are called cervical lesions. Specific changes that occur in feline odontoclastic resorptive lesion are hypercementosis, which causes bulb on the roots and super-eruption and thickening of the bone along the alveolar surface. Caries is the second most common human ailment and usually appears in places where food remains trapped and dental plaque is formed, i.e. in the tooth fissures, surfaces between teeth and the cervical parts of the tooth crown. Symptoms may include eating disorders and pain, while possible complications include inflammation of the gingiva, infection or abscess and loss of teeth. The initial carious lesion usually begins as a process of demineralization on smooth surfaces and appears as a white blur or white stain. Specific changes in caries are tubular sclerosis, pulp response at different stages of caries development in the form of tertiary dentine and gingival recession. Medical treatment of caries can be conservative or surgical. In conclusion, FORL and caries differ in their symptoms, etiology and therapy, while the most important difference is in their histopathology
Usporedba pokazatelja procjene boli u pasa s operacijskim lijeÄenjem puknuÄa prednjeg križnog ligamenta
The objective of this study was to compare postoperative pain, as assessed by multiple objective and subjective methods, after Tibial Tuberosity Advancement and Modified Retinacular Imbrication Technique, procedures that differ significantly in the extent of the operative trauma. We compared the preoperative, 2, 6, 10, 20, 44 and 68-hour postoperative results of the University of Melbourne Pain Scale and visual analogue scale with the dynamics of the physiologic, biochemical and behavioural parameters. The integration of various parameters increases the objectivity of pain assessment. The invasiveness of the surgical technique does not necessarily correlate with the level of postoperative pain.Cilj ovog istraživanja bila je usporedba poslijeoperacijske boli, procijenjene viÅ”estrukim objektivnim i subjektivnim metodama, nakon kranijalne transpozicije goljeniÄne kvrge i modificiranog postupka zatezanja retinakula, kirurÅ”kih zahvata koji se prema opsegu operacijske traume znatno razlikuju. Usporedili smo rezultate bodovnog sustava intenziteta boli SveuÄiliÅ”ta u Melbourneu i vizualne analogne skale s dinamikom fizioloÅ”kih, biokemijskih i bihevioralnih pokazatelja prije operacije te 2, 6, 10, 20, 44 i 68 sati poslije operacije. Objedinjavanje razliÄitih pokazatelja poveÄava objektivnost procjene boli. Invazivnost operacijske tehnike ne mora se nužno podudarati sa stupnjem poslijeoperacijske boli
Usporedba pokazatelja procjene boli u pasa s operacijskim lijeÄenjem puknuÄa prednjeg križnog ligamenta
The objective of this study was to compare postoperative pain, as assessed by multiple objective and subjective methods, after Tibial Tuberosity Advancement and Modified Retinacular Imbrication Technique, procedures that differ significantly in the extent of the operative trauma. We compared the preoperative, 2, 6, 10, 20, 44 and 68-hour postoperative results of the University of Melbourne Pain Scale and visual analogue scale with the dynamics of the physiologic, biochemical and behavioural parameters. The integration of various parameters increases the objectivity of pain assessment. The invasiveness of the surgical technique does not necessarily correlate with the level of postoperative pain.Cilj ovog istraživanja bila je usporedba poslijeoperacijske boli, procijenjene viÅ”estrukim objektivnim i subjektivnim metodama, nakon kranijalne transpozicije goljeniÄne kvrge i modificiranog postupka zatezanja retinakula, kirurÅ”kih zahvata koji se prema opsegu operacijske traume znatno razlikuju. Usporedili smo rezultate bodovnog sustava intenziteta boli SveuÄiliÅ”ta u Melbourneu i vizualne analogne skale s dinamikom fizioloÅ”kih, biokemijskih i bihevioralnih pokazatelja prije operacije te 2, 6, 10, 20, 44 i 68 sati poslije operacije. Objedinjavanje razliÄitih pokazatelja poveÄava objektivnost procjene boli. Invazivnost operacijske tehnike ne mora se nužno podudarati sa stupnjem poslijeoperacijske boli
Analiza cerebrospinalne tekuÄine u pasa s kralježniÄnim tumorom i hernijacijom intervertebralnog diska
The study presents a retrospective case study. This aim was to determine whether lactate, glucose and total protein in serum and cerebrospinal fluid (CSF) can be used as specific biochemical markers for rapid differential diagnosis between intervertebral disk herniation and spinal tumors. Canine blood (n=9) and cerebrospinal fluid (n=9) were collected for chemistry analysis in nine dogs divided into two groups: intervertebral disk herniation group (IVDHG) (n=6) and spinal tumor group (TG) (n=3). Absorption spectrophotometry was used for quantitative determination of the concentrations of lactate, glucose and total protein in serum and CSF. Lactate concentration in serum and CSF and glucose concentration in CSF were 40-60% higher in subjects in TG compared to the IVDHG group. Serum lactate concentrations in the IVDHG group were 60% lower than physiological values. The results indicate that elevated concentration of glucose, lactate and total proteins in CSF and serum are indicative of a tumor, while a decrease of serum lactate and other parameters within normal range indicate disk herniation.Ovo istraživanje predstavlja retrospektivnu studiju. Cilj ovog istraživanja bio je ustvrditi mogu li laktat, glukoza ili ukupni protein u serumu i cerebrospinalnoj tekuÄini biti specifiÄni biokemijski markeri u brzoj diferencijalnoj dijagnostici kralježniÄnog tumora i hernijacije intervertebralnog diska. U istraživanju je koriÅ”teno 9 uzoraka pseÄe krvi i 9 uzoraka pseÄe cerebrospinalne tekuÄine koje su biokemijski analizirane. Ukupno 9 je pasa podijeljeno u 2 skupine: hernijacija intervertebralnog diska (IVDHG) (n=6) i skupina vertebralni tumor (TG) (n=3). Za kvantitativno odreÄivanje koncentracija laktata, glukoze i ukupnih proteina u serumu i cerebrospinalnoj tekuÄini koristila se metoda apsorpcijske spektrofotometrije. Koncentracije laktatata u serumu i cerebrospnalnoj tekuÄini i glukoze u cerebrospinalnoj tekuÄini su bile poviÅ”ene za 40 do 60 % u pasa s tumorom u kralježnici u usporedbi s psima iz skupine s hernijacijom intervertebralnog diska. Serumska koncentracija laktata u pasa s hernijacijom intervertebralnog diska je bila 60 % niža nego fizioloÅ”ke vrijednosti. Rezultati ove studije su pokazali da poveÄane koncentracije glukoze, laktata i ukupnih proteina u cerebrospinalnoj tekuÄini upuÄuju na tumor u kralježnici, dok, smanjene ili fizioloÅ”ke vrijednosti laktata i ostalih mjerenih pokazatelja mjerenih u serumu i cerebrospinalnoj tekuÄini ukazuju na hernijaciju
intervertebralnog diska
Utjecaj transformirajuÄeg Äimbenika rasta beta 1 dokazanog u autolognom presatku omentuma na cijeljenje kritiÄnoga koÅ”tanoga defekta žbiÄne kosti kuniÄa.
Fracture healing is a complex physiological process. Multiple factors regulate this cascade of molecular reactions, affecting different sites in the osteoblast lineage, through various processes such as: migration, proliferation, chemotaxis, differentiation, inhibition, and extracellular protein synthesis. The omentum is a serous membrane made up of a lattice of blood vessels and fat. Basically, it is a highly vasculated organ with a rich source of angiogenic factors that promote the growth of blood vessels into whatever tissue it is placed close to. Recent studies have revealed that the omentum, apart from being a great source of various growth factors, also contains omnipotent stem cells that can differentiate into a variety of cell types. The study was carried out on 16 adult male New Zealand rabbits in the same condition. A large segmental defect was created in the radius of each animal in groups A and B. In group B the defect was filled with a piece omental fat tissue. The animals were euthanized 56 days after the operation and the bones removed for histomorphometric analysis. Histomorphometric analysis was performed. The osteoblast interface (Ob.S/BS) proved to be the statistically significant parameter (P = 0.005). An osteoblast interface was found in the treated group in contrast to the control. The surface of trabecula covered with the osteiod and osteoblast interface showed a high degree of positive linear correlation, in both the control and the treated group. Our study shows that the statistically significant osteoblast interface leads to the conclusion that omental fat tissue has a certain influence on bone turnover, especially on the formation of the newly-created bone.Cijeljenje loma kosti složeni je fizioloÅ”ki proces. ViÅ”e faktora regulira ovu kaskadu molekularnih reakcija utjeÄuÄi na osteoblaste kroz razne procese kao Å”to su migracija, proliferacija, kemotaksija, diferencijacija, inhibicija i ekstracelularna sinteza proteina. Omentum je serozna membrana koju Äini mreža krvnih žila i masnog tkiva. To je izrazito vaskulariziran organ koji je ujedno bogat izvor angiogenih faktora koji potiÄu rast krvnih žila u bilo kojem tkivu na koje ga se položi. Nedavna istraživanja su otkrila, da omentum osim Å”to je obilan izvor razliÄitih faktora rasta, takoÄer sadrži omnipotentne matiÄne stanice koje se mogu diferencirati u razne tipove stanica. Istraživanje je obavljeno na 16 odraslih mužjaka novozelandskog kuniÄa istog statusa. Na radijusu svake životinje, podijeljene u skupine A i B, uÄinjen je veliki segmentalni defekt. U skupini B defekt je bio ispunjen komadiÄem (isjeÄkom) masnog tkiva omentuma. Životinje su bile eutanazirane 56. dana nakon operativnog zahvata, a kosti su zatim izuzete za potrebe histomorfometrijske analize. UÄinjena je histomorfometrijska analiza. Sloj osteoblasta (Ob.S/BS) pokazao se kao statistiÄki znaÄajan pokazatelj (P = 0,005). Sloj osteoblasta ustanovljen je u pokusnoj skupini u usporedbi s kontrolnom skupinom. PovrÅ”ina trabekula pokrivena osteoidima i slojem osteoblasta pokazala je visok stupanj pozitivne linearne korelacije i u kontrolnoj i pokusnoj skupini. NaÅ”e istraživanje pokazuje da sloj osteoblasta statistiÄki znaÄajno poveÄan, te se može zakljuÄiti da masno tkivo omentuma ima stanoviti utjecaj na obnavljanje kostiju, naroÄito na formiranje novostvorene kosti
Utjecaj transformirajuÄeg Äimbenika rasta beta 1 dokazanog u autolognom presatku omentuma na cijeljenje kritiÄnoga koÅ”tanoga defekta žbiÄne kosti kuniÄa.
Fracture healing is a complex physiological process. Multiple factors regulate this cascade of molecular reactions, affecting different sites in the osteoblast lineage, through various processes such as: migration, proliferation, chemotaxis, differentiation, inhibition, and extracellular protein synthesis. The omentum is a serous membrane made up of a lattice of blood vessels and fat. Basically, it is a highly vasculated organ with a rich source of angiogenic factors that promote the growth of blood vessels into whatever tissue it is placed close to. Recent studies have revealed that the omentum, apart from being a great source of various growth factors, also contains omnipotent stem cells that can differentiate into a variety of cell types. The study was carried out on 16 adult male New Zealand rabbits in the same condition. A large segmental defect was created in the radius of each animal in groups A and B. In group B the defect was filled with a piece omental fat tissue. The animals were euthanized 56 days after the operation and the bones removed for histomorphometric analysis. Histomorphometric analysis was performed. The osteoblast interface (Ob.S/BS) proved to be the statistically significant parameter (P = 0.005). An osteoblast interface was found in the treated group in contrast to the control. The surface of trabecula covered with the osteiod and osteoblast interface showed a high degree of positive linear correlation, in both the control and the treated group. Our study shows that the statistically significant osteoblast interface leads to the conclusion that omental fat tissue has a certain influence on bone turnover, especially on the formation of the newly-created bone.Cijeljenje loma kosti složeni je fizioloÅ”ki proces. ViÅ”e faktora regulira ovu kaskadu molekularnih reakcija utjeÄuÄi na osteoblaste kroz razne procese kao Å”to su migracija, proliferacija, kemotaksija, diferencijacija, inhibicija i ekstracelularna sinteza proteina. Omentum je serozna membrana koju Äini mreža krvnih žila i masnog tkiva. To je izrazito vaskulariziran organ koji je ujedno bogat izvor angiogenih faktora koji potiÄu rast krvnih žila u bilo kojem tkivu na koje ga se položi. Nedavna istraživanja su otkrila, da omentum osim Å”to je obilan izvor razliÄitih faktora rasta, takoÄer sadrži omnipotentne matiÄne stanice koje se mogu diferencirati u razne tipove stanica. Istraživanje je obavljeno na 16 odraslih mužjaka novozelandskog kuniÄa istog statusa. Na radijusu svake životinje, podijeljene u skupine A i B, uÄinjen je veliki segmentalni defekt. U skupini B defekt je bio ispunjen komadiÄem (isjeÄkom) masnog tkiva omentuma. Životinje su bile eutanazirane 56. dana nakon operativnog zahvata, a kosti su zatim izuzete za potrebe histomorfometrijske analize. UÄinjena je histomorfometrijska analiza. Sloj osteoblasta (Ob.S/BS) pokazao se kao statistiÄki znaÄajan pokazatelj (P = 0,005). Sloj osteoblasta ustanovljen je u pokusnoj skupini u usporedbi s kontrolnom skupinom. PovrÅ”ina trabekula pokrivena osteoidima i slojem osteoblasta pokazala je visok stupanj pozitivne linearne korelacije i u kontrolnoj i pokusnoj skupini. NaÅ”e istraživanje pokazuje da sloj osteoblasta statistiÄki znaÄajno poveÄan, te se može zakljuÄiti da masno tkivo omentuma ima stanoviti utjecaj na obnavljanje kostiju, naroÄito na formiranje novostvorene kosti
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