2 research outputs found
Oxidative stress and superoxide dismutase activity in brain of rats fed with diet containing permethrin
Many pesticides have been reported to cause a lot of health problems in
workers, users and non-target organisms in the environment. Permethrin
containing insect pesticide has been reported to be toxic to non-target
organisms. However, the underlying mechanism involved in the toxicity
is not well understood. The present study was envisaged to investigate
the possible role of oxidative stress in permethrin neurotoxicity and
to evaluate the protective effect of superoxide dismutase (SOD)
activity in brain homogenates of Wistar rats. Oxidative stress measured
as thiobarbituric acid reacting substances (TBARS) was found to
significantly increase (p < 0.05) in all the experimental groups
compared with their parallel controls. Concomitantly, the activity of
SOD was found to decrease or increase significantly (p < 0.05) in
the experimental groups compared with their controls. Our result also
showed that activity of SOD was aged and concentration dependent.
Hence, the newly weaned rats appear to be more susceptible to the
pesticide contaminated diet because the SOD activity decreased more in
the brain homogenates compared with the middle aged rats or aged rats.
Observed aggressive behaviour was noticed in the pesticide exposed
rats, hence a possible neurobehavioral effect. The result demonstrated
that the pyrethroid insect powder exerts its toxic effect by promoting
oxidative stress in the brain and this may affect normal brain
functioning and growth
Oxidative stress and superoxide dismutase activity in brain of rats fed with diet containing permethrin
Many pesticides have been reported to cause a lot of health problems in
workers, users and non-target organisms in the environment. Permethrin
containing insect pesticide has been reported to be toxic to non-target
organisms. However, the underlying mechanism involved in the toxicity
is not well understood. The present study was envisaged to investigate
the possible role of oxidative stress in permethrin neurotoxicity and
to evaluate the protective effect of superoxide dismutase (SOD)
activity in brain homogenates of Wistar rats. Oxidative stress measured
as thiobarbituric acid reacting substances (TBARS) was found to
significantly increase (p < 0.05) in all the experimental groups
compared with their parallel controls. Concomitantly, the activity of
SOD was found to decrease or increase significantly (p < 0.05) in
the experimental groups compared with their controls. Our result also
showed that activity of SOD was aged and concentration dependent.
Hence, the newly weaned rats appear to be more susceptible to the
pesticide contaminated diet because the SOD activity decreased more in
the brain homogenates compared with the middle aged rats or aged rats.
Observed aggressive behaviour was noticed in the pesticide exposed
rats, hence a possible neurobehavioral effect. The result demonstrated
that the pyrethroid insect powder exerts its toxic effect by promoting
oxidative stress in the brain and this may affect normal brain
functioning and growth