Development of New Functional Feed that Utilizes Yacon (\u3cem\u3eSmallanthus sonchifolius\u3c/em\u3e) and Rush (\u3cem\u3eJuncus effuses\u3c/em\u3e L.) in Japan

Yacon (Smallanthus sonchifolius) is acknowledged as a food as well as a medicinal plant and its cultivation in Ja-pan has recently expanded. Rush (Juncus effuses L.) which is widely distributed in the temperate regions in the north-ern hemisphere, has historically been used as a herbal medicine for nephritis and dermal disorders. However, there is a lot of harvest residue of both plants. This research was conducted to find out the way for the effective use of these residues as functional feed resources

Diel vertical migration of zooplankton off Adélie Land (East Antarctica) during austral summer, 2010, inferred from echograms

第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月17日（木） 統計数理研究所 3階リフレッシュフロ

Distribution and population structure of two salps, Salpa thompsoni and Ihlea racovitzai off Lützow-Holm Bay in the Southern Ocean during austral summer

第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月17日（木） 統計数理研究所 3階リフレッシュフロ

Sex differences in patients with acute decompensated heart failure in Japan: observation from the KCHF registry

Aims: The association between sex and long‐term outcome in patients hospitalized for acute decompensated heart failure (ADHF) has not been fully studied yet in Japanese population. The aim of this study was to determine differences in baseline characteristics and management of patients with ADHF between women and men and to compare 1‐year outcomes between the sexes in a large‐scale database representing the current real‐world clinical practice in Japan. Methods and results: Kyoto Congestive Heart Failure registry is a prospective cohort study enrolling consecutive patients hospitalized for ADHF in Japan among 19 centres. Baseline characteristics, clinical presentation, management, and 1‐year outcomes were compared between men and women. A total of 3728 patients who were alive at discharge constituted the current study population. There were 1671 women (44.8%) and 2057 men. Women were older than men [median (IQR): 83 (76–88) years vs. 77 (68–84) years, P < 0.0001]. Hypertensive and valvular heart diseases were more prevalent in women than in men (28.0% vs. 22.5%, P = 0.0001; and 26.9% vs. 14.0%, P < 0.0001, respectively), whereas ischaemic aetiology was less prevalent in women than in men (20.0% vs. 32.5%, P < 0.0001). Women less often had reduced left ventricular ejection fraction (<40%) than men (27.5% vs. 45.1%, P < 0.0001). The cumulative incidence of all‐cause death or hospitalization for heart failure was not significantly different between women and men (33.6% vs. 34.3%, P = 0.71), although women were substantially older than men. After multivariable adjustment, the risk of all‐cause death or hospitalization for heart failure was significantly lower among women (adjusted hazard ratio: 0.84, 95% confidence interval: 0.74–0.96, P = 0.01). Conclusions: Women with heart failure were older and more often presented with preserved EF with a non‐ischaemic aetiology and were associated with a reduced adjusted risk of 1‐year mortality compared with men in the Japanese population

Optimal Intravascular Ultrasound-Guided Percutaneous Coronary Intervention in Patients With Multivessel Disease

BACKGROUND: Intravascular ultrasound (IVUS) was only rarely used in landmark trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel disease. OBJECTIVES: The authors aimed to evaluate clinical outcomes after optimal IVUS-guided PCI in patients undergoing multivessel PCI. METHODS: The OPTIVUS (OPTimal IntraVascular UltraSound)-Complex PCI study multivessel cohort was a prospective multicenter single-arm study enrolling 1, 021 patients undergoing multivessel PCI, including left anterior descending coronary artery using IVUS, aiming to meet the prespecified criteria (OPTIVUS criteria: minimum stent area > distal reference lumen area [stent length ≥28mm], and minimum stent area >0.8 × average reference lumen area [stent length <28mm]) for optimal stent expansion. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE) (death/myocardial infarction/stroke/any coronary revascularization). The predefined performance goals were derived from the CREDO-Kyoto (Coronary REvascularization Demonstrating Outcome study in Kyoto) PCI/CABG registry cohort-2 fulfilling the inclusion criteria in this study. RESULTS: In this study, 40.1% of the patients met OPTIVUS criteria in all stented lesions. The cumulative 1-year incidence of the primary endpoint was 10.3% (95% CI: 8.4%-12.2%), which was significantly lower than the predefined PCI performance goal of 27.5% (P < 0.001), and which was numerically lower than the predefined CABG performance goal of 13.8%. The cumulative 1-year incidence of the primary endpoint was not significantly different regardless of meeting or not meeting OPTIVUS criteria. CONCLUSIONS: Contemporary PCI practice conducted in the OPTIVUS-Complex PCI study multivessel cohort was associated with a significantly lower MACCE rate than the predefined PCI performance goal, and with a numerically lower MACCE rate than the predefined CABG performance goal at 1 year

Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry

OBJECTIVE: The complex link between nutritional status, protein and lipid synthesis, and immunity plays an important prognostic role in patients with heart failure. However, the association between appetite loss at discharge and long-term outcome remains unclear. METHODS: The Kyoto Congestive Heart Failure registry is a prospective cohort study that enrolled consecutive patients hospitalized for acute decompensated heart failure (ADHF) in Japan. We assessed 3528 patients alive at discharge, and for whom appetite and follow-up data were available. We compared one-year clinical outcomes in patients with and without appetite loss at discharge. RESULTS: In the multivariable logistic regression analysis using 19 clinical and laboratory factors with P value 1.0mg/dL (OR: 1.49, 95%CI: 1.04-2.14, P = 0.03), and presence of edema at discharge (OR: 4.30, 95%CI: 2.99-6.22, P<0.001) were associated with an increased risk of appetite loss at discharge, whereas ambulatory status (OR: 0.57, 95%CI: 0.39-0.83, P = 0.004) and the use of ACE-I/ARB (OR: 0.70, 95% CI: 0.50-0.98, P = 0.04) were related to a decreased risk in the presence of appetite loss. The cumulative 1-year incidence of all-cause death (primary outcome measure) was significantly higher in patients with appetite loss than in those without appetite loss (31.0% vs. 15.0%, P<0.001). The excess adjusted risk of appetite loss relative to no appetite loss remained significant for all-cause death (hazard ratio (HR): 1.63, 95%CI: 1.29-2.07, P<0.001). CONCLUSIONS: Loss of appetite at discharge was associated with worse 1-year mortality in patients with ADHF. Appetite is a simple, reliable, and useful subjective marker for risk stratification of patients with ADHF

ザイタク デ ニンチショウ オ ユウスル リョウヨウシャ オ カイゴ スル ダンセイ カイゴシャ ノ タイショ シャクド コウモク ノ ケントウ

在宅で認知症を介護する男性は年々増えている。最近の報告では、介護にかかわる事件の約2/3は、男性介護者である。介護を抱え困ったことがあっても悩みを人にうちあけない、相談しないなど、ソーシャルサポートに繋がることができない男性介護者の問題点が報告されている。しかし、現在、男性介護者の特徴や抱えている問題を客観的に測定するための対処尺度はない。今回の研究の目的は、男性介護者の対処尺度の項目を検討することである。まず、先行研究から男性介護者の対処における記述を抽出し既存の尺度と照合した。次に認知症療養者を在宅で介護している男性9名へ対処について調査を行った。さらに専門家と男性の対処について検討し、既存の対処尺度19項目に納まりきれない2項目を、新たに対処尺度の項目として追加した。The purpose of this paper was to report the development process of the scale for measuring for home care of male caregiver of dementia. First, male caregiver\u27s coping in precedence literatures reporting male caregivers of dementia applies with the pre-existing coping scale. Add questionnaire survey was given to 9 caregivers. And Experts in the field, consisting of university associate professors and specialists of dementia, established the content validity of the scale. Second, the category based on the main subject of the sentences. Each coping of sentences in a category was classified into 21 concepts, which form patients\u27 roles, and the sentences were then organized into 19 items for the primary questionnaire. Finally, the items were refined to represent the concepts, and carefully selected. Finally, the scale for measuring for home care of male caregiver of elderly of dementia, which consist of 21 items, was developed原著論文 = Original articl