Mathematical models for cell-matrix interactions during dermal wound healing

This paper contains a review of our recent work on the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing. The models are of partial differential equation type and allow us to investigate in detail how various mechanochemical effects may be responsible for certain wound healing disorders such as fibrocontractive and fibroproliferative diseases. We also present a model for wound healing angiogenesis. The latter has several features in common with angiogenesis during cancer tumour growth and spread so a deeper understanding of the phenomenon in the context of wound healing may also help in the treatment of certain cancers

Asymmetric Gaussian steering: when Alice and Bob disagree

Asymmetric steering is an effect whereby an inseparable bipartite system can be found to be described by either quantum mechanics or local hidden variable theories depending on which one of Alice or Bob makes the required measurements. We show that, even with an inseparable bipartite system, situations can arise where Gaussian measurements on one half are not sufficient to answer the fundamental question of which theory gives an adequate description and the whole system must be considered. This phenomenon is possible because of an asymmetry in the definition of the original Einstein-Podolsky-Rosen paradox and in this article we show theoretically that it may be demonstrated, at least in the case where Alice and Bob can only make Gaussian measurements, using the intracavity nonlinear coupler.Comment: 5 Pages, 4 Figure

A mathematical model for the capillary endothelial cell-extracellular matrix interactions in wound-healing angiogenesis

Angiogenesis, the process by which new blood capillaries grow into a tissue from surrounding parent vessels, is a key event in dermal wound healing, malignant-tumour growth, and other pathologic conditions. In wound healing, new capillaries deliver vital metabolites such as amino acids and oxygen to the cells in the wound which are involved in a complex sequence of repair processes. The key cellular constituents of these new capillaries are endothelial cells: their interactions with soluble biochemical and insoluble extracellular matrix (ECM) proteins have been well documented recently, although the biological mechanisms underlying wound-healing angiogenesis are incompletely understood. Considerable recent research, including some continuum mathematical models, have focused on the interactions between endothelial cells and soluble regulators (such as growth factors). In this work, a similar modelling framework is used to investigate the roles of the insoluble ECM substrate, of which collagen is the predominant macromolecular protein. Our model consists of a partial differential equation for the endothelial-cell density (as a function of position and time) coupled to an ordinary differential equation for the ECM density. The ECM is assumed to regulate cell movement (both random and directed) and proliferation, whereas the cells synthesize and degrade the ECM. Analysis and numerical solutions of these equations highlights the roles of these processes in wound-healing angiogenesis. A nonstandard approximation analysis yields insight into the travel ling-wave structure of the system. The model is extended to two spatial dimensions (parallel and perpendicular to the plane of the skin), for which numerical simulations are presented. The model predicts that ECM-mediated random motility and cell proliferation are key processes which drive angiogenesis and that the details of the functional dependence of these processes on the ECM density, together with the rate of ECM remodelling, determine the qualitative nature of the angiogenic response. These predictions are experimentally testable, and they may lead towards a greater understanding of the biological mechanisms involved in wound-healing angiogenesis

Travelling waves in wound healing

We illustrate the role of travelling waves in wound healing by considering three different cases. Firstly, we review a model for surface wound healing in the cornea and focus on the speed of healing as a function of the application of growth factors. Secondly, we present a model for scar tissue formation in deep wounds and focus on the role of key chemicals in determining the quality of healing. Thirdly, we propose a model for excessive healing disorders and investigate how abnormal healing may be controlled

Phase-space analysis of bosonic spontaneous emission

We present phase-space techniques for the modelling of spontaneous emission in two-level bosonic atoms. The positive-P representation is shown to give a full and complete description and can be further developed to give exact treatments of the interaction of degenerate bosons with the electromagnetic field in a given experimental situation. The Wigner representation, even when truncated at second order, is shown to need a doubling of the phase-space to allow for a positive-definite diffusion matrix in the appropriate Fokker-Planck equation and still fails to agree with the full quantum results of the positive-P representation. We show that quantum statistics and correlations between the ground and excited states affect the dynamics of the emission process, so that it is in general non-exponential.Comment: 16 pages, 6 figure

Silicon MINP solar cells

The MINP solar cell concept refers to a cell structure designed to be a base region dominated device. Thus, it is desirable that recombination losses are reduced to the point that they occur only in the base region. The most unique feature of the MINP cell design is that a tunneling contact is utilized for the metallic contact on the front surface. The areas under the collector grid and bus bar are passivated by a thin oxide of tunneling thickness. Efforts must also be taken to minimize recombination at the surface between grid lines, at the junction periphery and within the emitter. Results of both theoretical and experimental studies of silicon MINP cells are given. Performance calculations are described which give expected efficiencies as a function of base resistivity and junction depth. Fabrication and characterization of cells are discussed which are based on 0.2 ohm-cm substrates, diffused emitters on the order of 0.15 to 0.20 microns deep, and with Mg MIS collector grids. A total area AM 1 efficiency of 16.8% was achieved. Detailed analyses of photocurrent and current loss mechanisms are presented and utilized to discuss future directions of research. Finally, results reported by other workers are discussed

Indian nurses in Italy: a qualitative study of their professional and social integration

AIMS AND OBJECTIVES: To investigate the lived subjective experiences of immigrant Indian nurses in Italy and specifically their professional and social integration. BACKGROUND: To study the worldwide, nursing flux is a health priority in the globalised world. The growth in migration trends among nurses, not only from Philippines or India, has proliferated in recent years. The research on nurses' mobility for Southern European countries is underexplored, and in Italy, the out-migration flows of Indian nurses were never analysed. DESIGN: Qualitative methodological approach. METHODS: Semi-structured interviews (n = 20) were completed with Indian clinical nurses working in Italy for more than one year mainly in private organisations. A purposive sampling technique was used for recruitment. The data were then content-analysed using an inductive method. RESULTS: The findings were categorised into four themes: (1) aspects of professional integration and working experience, (2) intra- and interprofessional relationships and perceptions of the IPASVI Regulatory Nursing Board, (3) initial nursing education and continuous professional development and (4) perceptions of social integration. CONCLUSION: The results show that for Indian nurses in Italy emigration is important to gain opportunities to expand economic and social privileges as well as escape from historical assumptions of stigma associated with nursing work, especially for women. However, these conclusions have to be seen in wider socio-cultural complexities that are at the basis of transnational fluxes (Prescott & Nichter ). RELEVANCE TO CLINICAL PRACTICE: The research offers an insight into the complicated reasons for Indian nurses out-migration to Italy. Without comprehending the interwoven textures of the political and social relations that are continually constructed and re-constructed among different nations, it is difficult to understand nurses out-migration and consequently have a better and safer collaborative teamwork in the host countries

Production of relativistic positronium in collisions of photons and electrons with nuclei and atoms

We consider the production of ultrarelativistic positronium (Ps) in $\gamma A \to Ps + A$ and $e A \to Ps + e A$ processes where $A$ is an atom or a nucleus with charge $Ze$. For the photoproduction of para- and ortho-Ps and the electroproduction of para-Ps we obtain the most complete description compared with previous works. It includes high order $Z \alpha$ corrections and polarization effects. The accuracy of the obtained cross sections is determined by omitted terms of the order of the inverse Ps Lorentz factor squared. The studied high order multi-photon electroproduction of ortho-Ps dominates for the collision of electrons with heavy atoms over the bremsstrahlung production from the electron via a virtual photon proposed by Holvik and Olsen. Our results complete and correct the studies of those authors.Comment: 19 pages, 9 figures, RevTex; v2: minor corrections for the accuracy of the results, a discussion of the literature added in a footnote, one additional reference; v3: diagram of Fig.2 correcte

Spectroscopic Observations of Optically Selected Clusters of Galaxies from the Palomar Distant Cluster Survey

We have conducted a redshift survey of sixteen cluster candidates from the Palomar Distant Cluster Survey (PDCS) to determine both the density of PDCS clusters and the accuracy of the estimated redshifts presented in the PDCS catalog (Postman et. al. 1996). We find that the matched-filter redshift estimate presented in the PDCS has an error sigma_z = 0.06 in the redshift range 0.1 < z < 0.35 based on eight cluster candidates with three or more concordant galaxy redshifts. We measure the low redshift (0.1 < z < 0.35) space density of PDCS clusters to be 31.3^{+30.5}_{-17.1} * E-06 h^3 Mpc^-3 (68% confidence limits for a Poisson distribution) for Richness Class 1 systems. We find a tentative space density of 10.4^{+23.4}_{-8.4}* E-06 h^3 Mpc^-3 for Richness Class 2 clusters. These densities compare favorably with those found for the whole of the PDCS and support the finding that the space density of clusters in the PDCS is a factor of ~5 above that of clusters in the Abell catalog (Abell 1958; Abell, Corwin, and Olowin 1989). These new space density measurements were derived as independently as possible from the original PDCS analysis and therefore, demonstrate the robustness of the original work. Based on our survey, we conclude that the PDCS matched-filter algorithm is successful in detecting real clusters and in estimating their true redshifts in the redshift range we surveyed.Comment: 23 pages with 4 figures and 3 seperate tables. To be published in the November Issue of the Astronomical Journa