Substrate Support Ring for More Uniform Layer Thickness

Embodiments of substrate support rings providing more uniform thickness of layers deposited or grown on a substrate are provided herein. In some embodiments, a substrate support ring includes: an inner ring with a centrally located support surface to support a substrate; and an outer ring extending radially outward from the support surface, wherein the outer ring comprises a reaction surface area disposed above and generally parallel to a support plane of the support surface, and wherein the reaction surface extends beyond the support surface by about 24 mm to about 45 mm

Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study

Abstract Introduction The outcomes of patients ventilated for longer than average are unclear, in part because of the lack of an accepted definition of prolonged mechanical ventilation (PMV). To better understand the implications of PMV provision, we compared one-year health outcomes between two common definitions of PMV as well as between PMV patients and those ventilated for shorter periods of time. Methods We conducted a secondary analysis of prospectively collected data from medical and surgical intensive care units at an academic tertiary care medical center. The study included 817 critically ill patients ventilated for ≥ 48 hours, 267 (33%) of whom received PMV based on receipt of a tracheostomy and ventilation for ≥ 96 hours. A total of 114 (14%) patients met the alternate definition of PMV by being ventilated for ≥ 21 days. Survival, functional status, and costs were measured at baseline and at 2, 6, and 12 months after discharge. Of one-year survivors, 71 (17%) were lost to follow up. Results PMV patients ventilated for ≥ 21 days had greater costs ($140,409 versus$143,389) and higher one-year mortality (58% versus 48%) than did PMV patients with tracheostomies who were ventilated for ≥ 96 hours. The majority of PMV deaths (58%) occurred after hospital discharge whereas 67% of PMV patients aged 65 years or older had died by one year. At one year PMV patients on average had limitations in two basic and five instrumental elements of functional status that exceeded both their pre-admission status and the one-year disability of those ventilated for < 96 hours. Costs per one-year survivor were $423,596,$266,105, and $165,075 for patients ventilated ≥ 21 days, ≥ 96 hours with a tracheostomy, and < 96 hours, respectively. Conclusion Contrasting definitions of PMV capture significantly different patient populations, with ≥ 21 days of ventilation specifying the most resource-intensive recipients of critical care. PMV patients, particularly the elderly, suffer from a significant burden of costly, chronic critical illness and are at high risk for death throughout the first year after intensive care

Serologic Cross-Reactivity with Pandemic (H1N1) 2009 Virus in Pigs, Europe

We tested serum samples from pigs infected or vaccinated with European swine influenza viruses (SIVs) in hemagglutination-inhibition assays against pandemic (H1N1) 2009 virus and related North American SIVs. We found more serologic cross-reaction than expected. Data suggest pigs in Europe may have partial immunity to pandemic (H1N1) 2009 virus

Predictions of the L[CII]_{\rm[CII]}-SFR and [CII_{\rm II}] Luminosity Function at the Epoch of Reionization

We present the first predictions for the $L_{\rm [CII]}$ - SFR relation and [CII] luminosity function (LF) in the Epoch of Reionization (EoR) based on cosmological hydrodynamics simulations using the SIMBA suite plus radiative transfer calculations via S\'IGAME. The sample consists of 11,137 galaxies covering halo mass $\log M_{\rm halo}\in$[9, 12.4] $M_\odot$, star formation rate SFR$\in$[0.01, 330] $M_\odot$ yr$^{-1}$, and metallicity $<Z_{\rm gas}>_{\rm SFR}\in$[0.1, 0.9] $Z_\odot$. The simulated $L_{\rm [CII]}$-SFR relation is consistent with the range observed, but with a spread of $\simeq$0.3 dex at the high end of SFR ($>$100 $M_\odot$ yr$^{-1}$) and $\simeq$0.6 dex at the lower end, and there is tension between our predictions and the values of $L_{\rm [CII]}$ above 10$^{8.5}$ $L_\odot$ observed in some galaxies reported in the literature. The scatter in the $L_{\rm [CII]}$-SFR relation is mostly driven by galaxy properties, such that at a given SFR, galaxies with higher molecular gas mass and metallicity have higher $L_{\rm [CII]}$. The [CII] LF predicted by SIMBA is consistent with the upper limits placed by the only existing untargeted flux-limited [CII] survey at the EoR (ASPECS) and those predicted by semi-analytic models. We compare our results with existing models and discuss differences responsible for the discrepant slopes in the $L_{\rm [CII]}$-SFR relatiion.Comment: 19 pages, 14 figures, Accepted by Ap

Detection of local-scale population declines through optimized tidal marsh bird monitoring design

Evaluating the efficacy of monitoring designs is crucial for the successful monitoring and conservation of populations. For tidal marsh bird species of conservation concern, detecting population declines at local spatial scales within actionable time frames is a top priority. We examined and compared the effectiveness of alternative monitoring strategies for detecting local-scale population declines using count data from 1176 spatially-independent salt marsh sampling points throughout the northeastern United States (Maine to Virginia). We used abundance estimates that accounted for imperfect detection as initial conditions to simulate annual population declines of 5%, 10%, 30%, and 50% over a 5-year sampling period. Under an optimal monitoring design with biennial sampling, we were able to successfully detect annual population declines of ≥30% for each species and for all species combined. However, this required a minimum of 15–20 points per site being sampled. Power to detect declines, although low for detecting smaller annual declines (i.e., \u3c10%), improved substantially when points were visited twice per season, yet a third visit provided a reduced benefit. When testing factors that could potentially influence power to detect declines, we found that the power within sites was positively related to species abundance. Power was similar between biennial sampling (3 of 5 years) and annual sampling (5 of 5 years), suggesting a more cost-effective approach would be to sample every other year. We found that within most sites, detecting annual declines of 10% or less over a relatively short 5-year duration would be difficult. Hence, we recommend that salt marsh bird monitoring programs in the northeastern United States conduct two visits to each site per sampling year, include 15 or more sampling points per site (without confounding spatial independence), and conduct monitoring efforts every other year. This approach will maximize the efficacy of site-level monitoring of tidal marsh birds, which can aid in assessments of coastal wetland conservation and related habitat management efforts