Prevalence and awareness about Chlamydial infection in women undergoing infertility evaluation in Lagos, Nigeria

Purpose: To determine the prevalence and level of awareness of genital Chlamydia trachomatis infection and possible correlative factors among women undergoing infertility evaluation. Methods: The study involved analysis of demographics and results of chlamydia screening in 77 infertile women undergoing evaluation over a six month period in Lagos, Nigeria. Results: The mean age was 32 + 6.4 yr (range 20-39 yr). Chlamydia screening was positive in 14 (18.2%). Awareness about the existence, symptomatology, mode of infection and complications was poor. Statistically significant correlation existed between prevalence of chlamydia infection and age, previous history of sexual infection and minimum of one sexual partner in the last one year (

Review of chorionic Villus sampling in prenatal diagnosis

Advances in biotechnology with the introduction of the ultrasound scan and the application of polymerase chain reaction has made fetal medicine an interesting field of study. The fetus can now be easily assessed and its genetic constitution determined with relative ease and degree of accuracy, in the process referred to as prenatal diagnosis. Invasive prenatal diagnosis continues to be gold standard in pregnancies at increased risk of congenital abnormalities with chorionic villus sampling being one of the principal methods of prenatal diagnosis. Although not widely available in most developing countries, chorionic villus sampling is the procedure of choice for prenatal diagnosis with the principal advantage over others, of its being done in the first trimester. This review summarized the historical perspective, timing , route and methodology of sampling, looks at the complications and draw backs of the procedure and also examines the controversial aspects of the procedure. Its utilization is advocated in developing countries. KEY WORDS: Prenatal diagnosis (PND), Chorionic villus sampling (CVS), Polymerase chain reaction (PCR). [Nig J Clinical Practice Vol.5(1) 2002: 45-51