Cellules souches embryonnaires et étude du développement du système vasculaire

GRENOBLE1-BU Sciences (384212103) / SudocSudocFranceF

Voix publiques (environnements sonores, représentations et usages d'habitation dans un quartier populaire de Naples)

Partant d'une ethnographie des Quartiers Espagnols, quartier populaire de Naples, cette recherche est une étude de la dimension sociale des environnements sonores. Pluridisciplinaire, cette anthropologie sonore convoque l'anthropologie sociale, urbaine et sensorielle, la microsociologie, l'anthropologie de la communication et la prosodie. L'observation de la vie quotidienne et de ses "manières de faire" révèle des pratiques d'habitation de la rue privilégiant la polyvalence des espaces de l'intime et du collectif. Il s'en dégage la diversité des stratégies d'appropriation de l'espace urbain, et une particulière porosité de l'habitat sur les plans sociaux et sensoriels, dans laquelle la dimension sonore est centrale. La vocalité, production sonore privilégiant la relation à l'autre, est au centre de la vie sociale du quartier. L'analyse croisée des "voix publiques", cris de marchands et communications domestiques à distance, témoigne d'enjeux fondamentaux de la vie sociale. De leur côté, les discours et représentations attachés aux sonorités issues des pratiques populaires pyrotechniques révèlent, en tant que plaisir du bruit, une même volonté d'investir l'espace urbain par le biais de son environnement sonore. Considérant que voix et pyrotechnie peuvent constituer des environnements sonores, il apparaît que pour autant qu'ils peuvent diviser à certains égards, ils rassemblent les habitants qui se sentent en faire partie et participent de la fabrication du lien social. Pointant la pertinence anthropologique de l'observation et la documentation du fait sonore, cette étude met en évidence les corrélations entre les modes d'habitation et les environnements sonores.Based on an ethnography of the Quartieri Spagnoli, a neapolitan popular area, this research is a study of social aspects of sonic environments. This pluridisciplinary sound anthropology deals with social, urban and sesorial anthropology, microsociology, anthropology of communication as well as prosody studies. The observation of everyday life and its "way of doing" shows different modalities of occupying space that underline polyvalence of intimate and collective spaces. The street let see appropriation strategies as well as a aprticular porosity of habitat in social and perceptive levels, in which the dimension of sound is central. Vocality, as a sonic production based on relation to the others, has a central place in the social life of the area. Crossed analysis of the "public voices" (sellers shouts and domestic distant communications) allows to reveal fundamental stakes of relations between inhabitants. On the other hand, representation discourses linked to popular firework practices, as a pleasure of noise, let see a same kind of intention of surrounding urban space by the way of its sonic environment. As long as voice and pyrotechnics can constitute sonic environments, it appears that, even if they may sometimes divide, they gather together the inhabitants that feel themselves integrated in it and partake of making social link. Insisting on anthropological pertinence of observing and using sound as an ethnographic document this study highlights connexions between ways of "living in" and sonic environments.PARIS-Médiathèque MQB (751132304) / SudocPARIS-Fondation MSH (751062301) / SudocSudocFranceF

Generation of induced pluripotent stem cell (iPSC) line from a patient with triple negative breast cancer with hereditary exon 17 deletion of BRCA1 gene

BRCA1 germline mutation confers hereditary predisposition for breast and ovarian cancer. To understand the physiopathology of mammary and ovarian epithelial cancer transformation, and to identify early driver molecular events, we have generated an iPSC line from a patient carrying a germline exon 17 deletion in BRCA1 gene (BRAC1Ex17 iPSC) in a high-risk family context. Blood cells were reprogrammed used non-integrative virus of Sendaï. The BRCA1-deleted iPSC had normal karyotype, harboured a deletion in the exon 17 of the BRCA1 gene, expressed pluripotent hallmarks and had the differentiation capacity into the three germ layers

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation

Heterozygous activating mutation (p.Glu227Lys) in KCNJ11 leads to maturity-onset diabetes of the young (MODY) type 13, that is a subtype of dominant inherited young-onset non-autoimmune diabetes due to a primary defect in pancreatic beta cells. We generated induced pluripotent stem cells (iPSCs) from a patient with KCNJ11p.Glu227Lys mutation who developed MODY at 13 years old. KCNJ11p.Glu227Lys-mutated cells that were reprogrammed by non-integrative viral transduction had normal karyotype, harboured the KCNJ11p.Glu227Lys mutation, expressed pluripotency hallmarks and had the differentiation capacity into the three germ layers

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation

Heterozygous non-synonymous (p.S142F) mutation in HNF1A leads to maturity-onset diabetes of the young (MODY) type 3, which is a subtype of dominant inherited young-onset non-autoimmune diabetes due to the defect of insulin secretion from pancreatic beta cells. We generated induced pluripotent stem cells (iPSCs) from a patient with HNF1A p.S142F mutation. Cells from this patient, which were reprogrammed by non-integrative viral transduction had normal karyotype, harboured the HNF1A p.S142F mutation, expressed pluripotency hallmarks

Derivation of induced pluripotent stem cells from an infertile boar carrying a reciprocal translocation

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