2020-04-17/18 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: Daily NM Recap. Stimulus checks. Whitehouse reopening guidelines. Increased suicide calls. Commentary on COVID and African Americans. NYC ventilation rate. 300K African deaths predicted. Thai horse virus outbreak. Europe eases lockdown. UK vaccine research. Chinese death undercount. Biosafety breaches. General wearing of masks. PPE for emergency physician. FDA approves safer swabs. Mental health lockdown impact. Intermittent social distancing. Undetected US cases. NYC hospitalization characteristics. Adapting veterinary surveillance. Infectious disease” hospital. NIH vaccine and treatment partnership. Repurposing anesthetic machines as ventilators. Guidance for psychiatrists. Elective surgery risk stratification. Hemodialysis facility. Pathologist on IgG/M tests. Abnormal coagulation and ECMO. Paramedic guidance. Dialysis and transplants. Critically ill management. GI guidance. Otorhinolaryngology head & neck surgery. Emergency nursing management. Lung surgery. Metabolic & bariatric surgery. Convalescent plasma therapy effectiveness. Potential antivirals. UK testing. Spike proteins for potential vaccine. Cytokines suggest IL-6 antagonist treatments. Mental health messaging. $483 million for mRNA-1273 vaccine trial. WHO unsure about antibody protection. Complications for IBD. Hospitalizations characterized. Social distancing and personality. Digital COVID-19 literature database available

2020-04-16 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: Daily NM recap. Public Catholic masses resume. Chaplains stand down. Food delivered to tribal communities. Governors order face coverings use. Campfires restricted. NY hospitalizations fall. Nursing home probe in NJ. GOP call WHO Chief resignation. Africa cases up 51% and deaths up 60%. Sub-Saharan Africa prediction. Resurgence in Japan. UK conditions to reopen. France deaths up. UNMH protests over PPE. Med center financial stress. Hospitals bailout insufficient. 55% US healthcare worker cases hospital spread. Cruise ship transmission. Essential contact tracing. JAMA editors discuss policy. Guideline updates: treatment, emergency dep, ophthalmology, cath lab, telemedicine, liver disease, caregiver, health care facilities, FEMA, homeless services. Calcium channel blocker reduces fatality. Interferon lambda treatment. No benefit for lopinavir/ritonavir or arbidol in RCT. Donate plasma. Mixed results for antivirals on clearance. 37 new trials. Population-scale testing proposed. New rapid assay. Serology + RT-PCR needed. Hemoglobin monitoring. Co-infection of SARS-CoV-2. Urine glucose and proteinuria predict severity. Use damp cloth covers

2020-04-24 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NYT praises NM. NM Governor update. NM cases. NM antibody tests. State hiring freeze. Navajo Nation sues. Navajo Nation CA doctors. Mental health funding. Balloon Fiesta proceeding. Trump Lysol remarks. $484B business relief. 50k US deaths. US no to WHO initiatives. US crime reductions. Moscow 10% infections. Quebec elderly deaths. Italy psychiatric sequelae. Global vaccines summit. French nicotine sales restrictions. Adaptive cyclic exit strategies. Mask reuse techniques. Mask steaming method. Legionnaire’s reopening risks. Youth mental health. US disease models. Covid phobia treatment avoidance. Nursing home testing. Home nursing demand. CDC home cleaning. Guidelines on: convalescent plasma transfusion, H2O2 nasal use, pre-op testing, respiratory distress, ophthalmological practice, GI department reopening. FDA hydroxychloroquine cautions. Chloroquine high-dose mortality. HCQ+azithromycin long-QT. Iron reduction adjuvant. Repurposing prioritization. Pediatric HCQ dosing. HCQ enrollment up. 107 trials registered. PPE skin injuries. LDL and severity. 32 ECMO patients. Worse outcomes older monkeys

2020-04-10 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: Extra NM HSD SNAP benefits. NM cases \u3e1000. Meds supply chain threatened. Mass graves in NY. Surgeon General screening app. Presidential briefing. Italian healthcare worker deaths. Taiwan tiered care model. Communicating risks to public. French public demand hydroxychloroquine. Vaccination pause dangers. Retesting needed after discharge. CDC report geography and incidence. UW clinical informatics response. UW preparedness guidelines. Wuhan outbreak control. CDC asymptomatic exposed worker guidelines. Mask innovation. Unemployment spikes. Workforce gaps. Workspace modifications reduce transmission. Guidelines and recommendations: ER physician, surgery, cardiopulmonary resuscitation, chest imaging, geriatrics, critically ill children, postpyloric tube placement, genitourinary malignancies, obstetrics, and home work health. Remdesivir clinically promising. Hydroxychloroquine safe but higher mortality with azithromycin. Lockdown health risks. Post-ICU syndrome. Tetracyline therapy potential. ACE2 review. Repurposing candidates. Patient self-triage tool. Video of aerosol spread and lingering. Modeling challenges. 34 new clinical trials registered today

2020-04-11/12 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: No NM church gatherings. NM a testing champ. Consolidation of elderly care. NM case update. 50-state disaster. Ventilator haggling. Economy reopening planning. PPE decontamination. Hospital ward contamination. Prolonged return to normal. FEMA projections. WHO tracking app. China SEIR model. Hubei epi. Mortality best measure. Covid-19 wave 2. Public should wear masks. Civil liberties. Safe grocery shopping. School closure impact. CDC caretaker guidelines. Psychiatric mobilization. Keep newborns with mom. C-section protocol. Italian obstetrics. Pediatric cardiac catherization. Chinese anesthesiology consensus. Cancer guidelines. Neuro-oncologic Tx. Radiology algorithm. Lung ultrasonography. ARF care. VTE common and predictable. Liver transplantation. Auto-immune treatments. Extracorporeal kidney involvement. Nutrition support. GI endoscopy. No stay-at-home for stroke. Intensive care collaboration. Supine swab collection. Lab tests for severity. Testing assay performance. False negative RT-PCR tests. IgM and IgG serum tests. FDA convalescent plasma. Blood purification device approval. Erythropoietin treatment. Tissue plasminogen activator. ECMO. Lopinavir/ritonavir study results. Immunotherapy review. Vaccine development. Hydroxychloroquine review. Candidates from in silico/virtual screening. Traditional Indian therapies. US trials update. Pathways and risk factors for death. ACE2 polymorphism. Severity in children. Lung tissue replication. Phylogenetic tracing. Text mining dataset. Risk by blood type

2020-05-13 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: APS virtual graduation. NM Governor update. Free testing for all. NM 2020 census challenges. BCBS $1M COVID-19 donation. NM case count. Most tribes infected. Increased NM Medicaid enrollment. UNM revenue losses. UNM limited operations continue. No dine-in eating yet. Clothing store reopening measures. Aid package. Consumer prices tumble. Public guidance adherence survey. Healthcare resource prediction. Food insecurity. Supply system comparison. Pentagon PPE award. Ensemble mortality model. 4.4% French infections. Asymptomatic spread. Traffic infection correlation. Comorbid COPD/smoking mortality. Airplane transmission contained. CDC COVID-19 statistics. WHO: endemic virus risk. Iceland tracking app impact. WHO: prison management. Quality of life. Containment amongst HCWs. Emotional regulation. Literature overload coping. Exercise and well-being. Information sources. Distress among healthcare students. Expanding pharmacy role. Recommendations on sedation in mechanical ventilation. Long-acting antipsychotics usage. Comorbidities and mortality. Continuing clinical trials. Short interval re-testing. Pharynx gargle samples. BCG vaccination not protective. Plasmapheresis case series. Convalescent plasma safety. Neutralizing antibodies. 40 new trials. Acute kidney injury. Multiorgan and renal tropism. Intestinal cell infections. Cardiovascular disease risk link. Cutaneous manifestations. Underpowered studies

2020-04-30 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM residential facility deaths. NM case update. NM TriCore testing antibodies. Navajo nation cases. May 10 Navajo peak. Udall funding push. El Paso shopping discouraged. NM budget shortfall. Santa Fe furlough. Ethanol sanitizer safety. LA free testing for all. Michigan protest. NM Batelle N95 decontamination. Hospital revenue decline. Wastewater early detection. German herd immunity. 60-day viral shedding possible. Temporary infected “ark”. Prison release preparedness. Low quality research. Phased long-term care. Suicide prevention. Corticosteroid tradeoffs. Cloth mask guidelines. SARS-CoV-2 assays compared. IgG and viral loads. Better testing reporting. Dubious testing vendors. Promising oral drug. Hydroxychloroquine prophylaxis dosing. Umifenovir ineffective. Multi-drug nanoparticles. Drug discovery new targets. 38 new COVID-19 trials. Cancer research review. Attenuated SARS-CoV-2

2020-05-04 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM convalescent plasma call. NM case counts. Gallup lockdown continues. Tribal federal relief delay. Childcare demand drops. Polling open for primaries. Non-US world funds R&D. South Korea eases more. Soft quarantine inefficiency. Chinese interventions. Transmission window. December French case. CDC on law enforcement, essential errands. NEJM on telemedicine. Practice guidelines for: ECMO, pneumonia, nuclear medicine SOP. FDA antibody test restrictions. Africa testing differences. PCR assay sensitivity. Wuhan antibody tracking. Hydroxychloroquine toxicity. Remdesivir mechanism. Tocilzumab study inconclusive. SARs-CoV-2 structure. 28 new trials. Immunology and exercise. Synthetic SARS-CoV-2. IgM and IgG responses. Bacterial and fungal coinfection. Youth mental health challenges

2020-06-12/13/14 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM case count. Increased road travel. ABQ ART to resume. Film industry to reopen. US Highlights: Policy advocacy to end mass Incarceration. International Highlights: COVID-19 cases in Italy. Temperature checks at Canada airports. Economics, Workforce, Supply Chain, PPE: Epidemiology Highlights: Mask stability. Supply operations management. Masks going to transport companies. Digital tools for awareness. Customers like clean stores. Epidemiology: Michigan hospitalization risk factors. Ranking the risks of reopening. Pandemic growth rate scaling. Outbreak detection and contract tracing. Worldwide mortality report. Screening pregnant women. Social learning model for pandemics. Healthcare Policy Recommendations: Re-opening of sports centers. Minimize airborne transmission indoors. Open pathogen genomic analysis. South Korea’s response to pandemic. Practice Guidelines: The accumulating burden of non-COVID-19 illnesses. Caution on early intubation and mechanical ventilation in COVID-19. Recommendations on management of IBD, labor and delivery, spinal surgery (risk stratification), and home dialysis. Testing: Robust antibody response. Missed patients with low viral load. Drugs, Vaccines, Therapies, Clinical Trials: Observational study of ACEIs & ARBs. Benefit of lenzilumab. New COVID-19 trials. Other Science: Cardiac biomarkers and mortality. Telemedicine in neurology. High rates of VTE

Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya

Abstract Background Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. P. falciparum exerts strong selection pressure on sickle cell trait (SCT), alpha thalassemia (-α3.7/αα), glucose-6-phosphate dehydrogenase (G6PD), and merozoite surface protein 2 (MSP-2) variants (FC27, 3D7) that confer reduced malarial disease severity. The current study tested the hypothesis that SCT, (-α3.7/αα), G6PD mutation and (MSP-2) variants (FC27, 3D7) are associated with an early age of EBV acquisition. Methods Data on infant EBV infection status ( A)/Chinese (1024 C > T) (OR = 2.614, P = 0.212)] and [Union (1360 C > T)/Kaiping (1388G > A) (OR = 0.321, P = 0.295)]. There was no relationship between EBV acquisition and in-utero exposure to either FC27 (OR = 0.922, P = 0.914) or 3D7 (OR = 0.933, P = 0.921). In addition, EBV acquisition in infants ≥ 6–12 months also showed no association with -α3.7/αα (OR = 0.681, P = 0.442), SCT (OR = 0.513, P = 0.305), G6PD [(Viangchan (871G > A)/Chinese (1024 C > T) (OR = 0.640, P = 0.677)], [Mahidol (487G > A)/Coimbra (592 C > T) (OR = 0.948, P = 0.940)], [(Union (1360 C > T)/Kaiping (1388G > A) (OR = 1.221, P = 0.768)], African A (OR = 0.278, P = 0.257)], or in utero exposure to either FC27 (OR = 0.780, P = 0.662) or 3D7 (OR = 0.549, P = 0.241). Conclusion Although hemoglobinopathies (-α3.7/αα, SCT, and G6PD mutations) and in-utero exposure to MSP-2 were not associated with EBV acquisition in infants 0–12 months, novel G6PD variants were discovered in the population from western Kenya. To establish that the known and novel hemoglobinopathies, and in utero MSP-2 exposure do not confer susceptibility to EBV, future studies with larger sample sizes from multiple sites adopting genome-wide analysis are required