2 research outputs found
Blood glucose-lowering effect of Telfairia Occidentalis : A preliminary study on the underlying mechanism and responses
The effects of aqueous extract of Telfairia Occidentalis leaf (TO) on
plasma glucose, lactate dehydrogenase activity (LDH), insulin and
cortisol levels in rats were investigated. Thirty male Wistar rats
(200 12250g) were randomly divided into 5 groups (n=6/group). Rats
in the control group received 0.2 ml of normal saline while rats in
other groups were orally treated with 100 or 200 mg/Kg of the extract
for either 1 or 2 weeks. The results showed that there were significant
increases in insulin and cortisol levels, decrease in glucose, and an
insignificant increase in LDH activity in rats treated with 100 and 200
mg/Kg of the extract for 1 week. However, after 2 weeks of treatment
with the same doses, there was no significant change in plasma insulin
in the treated rats when compared with the control. In contrast, there
was a significant decrease in plasma insulin levels when compared with
what was obtained after one week of treatment. The reduction in plasma
insulin was accompanied by increases in plasma glucose towards normal
and significant increases in plasma cortisol and LDH activity. The
results suggest that the blood glucose-lowering effect of Telfairia
Occidentalis might be mediated at least in part by insulin. This effect
elicited counterregulatory responses that included an increase in
plasma cortisol and lactate dehydrogenase activity to probably
stimulate cortisol-induced gluconeogenesis and favor lactate oxidation
Blood glucose-lowering effect of Telfairia Occidentalis : A preliminary study on the underlying mechanism and responses
The effects of aqueous extract of Telfairia Occidentalis leaf (TO) on
plasma glucose, lactate dehydrogenase activity (LDH), insulin and
cortisol levels in rats were investigated. Thirty male Wistar rats
(200−250g) were randomly divided into 5 groups (n=6/group). Rats
in the control group received 0.2 ml of normal saline while rats in
other groups were orally treated with 100 or 200 mg/Kg of the extract
for either 1 or 2 weeks. The results showed that there were significant
increases in insulin and cortisol levels, decrease in glucose, and an
insignificant increase in LDH activity in rats treated with 100 and 200
mg/Kg of the extract for 1 week. However, after 2 weeks of treatment
with the same doses, there was no significant change in plasma insulin
in the treated rats when compared with the control. In contrast, there
was a significant decrease in plasma insulin levels when compared with
what was obtained after one week of treatment. The reduction in plasma
insulin was accompanied by increases in plasma glucose towards normal
and significant increases in plasma cortisol and LDH activity. The
results suggest that the blood glucose-lowering effect of Telfairia
Occidentalis might be mediated at least in part by insulin. This effect
elicited counterregulatory responses that included an increase in
plasma cortisol and lactate dehydrogenase activity to probably
stimulate cortisol-induced gluconeogenesis and favor lactate oxidation