2 research outputs found
Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk
Background: The aim of this study was to investigate the role of gene
variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic
susceptibility to periapical pathosis.
Material and Methods: One hundred patients were included in the study
and divided into two groups as follows; Control Group (n=50) that have
root canal treatment and no periapical lesion, Patient Group (n=50) that
have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3
(c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were
genotyped by using PCR-RFLP. Genotypical analysis of control and patient
groups were investigated to disclose whether there is any association
between periapical lesions and gene variations.
Results: There are no significant statistical differences between
control and patient groups according to TLR 2 and 4 gene sequence. On
the contrary, CC allele detected 74\% for TLR 3 in patient group, and
this difference was found to be statistically significant (p < 0.005).
Conclusions: According to these results, it can be suggested that
patients with Toll-like receptor 3 gene polymorphisms could be
susceptible to periapical pathosis