Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Real-Time Tsunami Prediction System Using DONET

We constructed a real-time tsunami prediction system using the Dense Oceanfloor Network System for Earthquakes and Tsunamis (DONET). This system predicts the arrival time of a tsunami, the maximum tsunami height, and the inundation area around coastal target points by extracting the proper fault models from 1,506 models based on the principle of tsunami amplification. Since DONET2, installed in the Nankai earthquake rupture zone, was constructed in 2016, it has been used in addition to DONET1 installed in the Tonankai earthquake rupture zone; we revised the system using both DONET1 and DONET2 to improve the accuracy of tsunami prediction. We introduced a few methods to improve the prediction accuracy. One is the selection of proper fault models from the entire set of models considering the estimated direction of the hypocenter using seismic and tsunami data. Another is the dynamic selection of the proper DONET observatories: only DONET observatories located between the prediction point and tsunami source are used for prediction. Last is preparation for the linked occurrence of double tsunamis with a time-lag. We describe the real-time tsunami prediction system using DONET and its implementation for the Shikoku area

Development of a Practical Evaluation Method for Tsunami Debris and Its Accumulation

Tsunami-related fires may occur in the inundation area during a huge tsunami disaster, and woody debris produced by the tsunami can cause the fires to spread. To establish a practical method for evaluating tsunami-related fire predictions, we previously developed a method for evaluating the tsunami debris thickness distribution that uses tsunami computation results and static parameters for tsunami numerical analysis. We then used this evaluation method to successfully reproduce the tsunami debris accumulation trend. We then developed an empirical building fragility function that relates the production of debris not only to inundation depth but also to the topographic gradient and the proportion of robust buildings. Using these empirical evaluation models, along with conventional tsunami numerical analysis data, we carried out a practical tsunami debris prediction for Owase City, Mie Prefecture, a potential disaster area for a Nankai Trough mega-earthquake. This prediction analysis method can reveal hazards which go undetected by a conventional tsunami inundation analysis. These results indicate that it is insufficient to characterize the tsunami hazard by inundation area and inundation depth alone when predicting the hazard of a huge tsunami; moreover, more practically, it is necessary to predict the hazard based on the effect of tsunami debris

Development of a Practical Evaluation Method for Tsunami Debris and Its Accumulation

Tsunami-related fires may occur in the inundation area during a huge tsunami disaster, and woody debris produced by the tsunami can cause the fires to spread. To establish a practical method for evaluating tsunami-related fire predictions, we previously developed a method for evaluating the tsunami debris thickness distribution that uses tsunami computation results and static parameters for tsunami numerical analysis. We then used this evaluation method to successfully reproduce the tsunami debris accumulation trend. We then developed an empirical building fragility function that relates the production of debris not only to inundation depth but also to the topographic gradient and the proportion of robust buildings. Using these empirical evaluation models, along with conventional tsunami numerical analysis data, we carried out a practical tsunami debris prediction for Owase City, Mie Prefecture, a potential disaster area for a Nankai Trough mega-earthquake. This prediction analysis method can reveal hazards which go undetected by a conventional tsunami inundation analysis. These results indicate that it is insufficient to characterize the tsunami hazard by inundation area and inundation depth alone when predicting the hazard of a huge tsunami; moreover, more practically, it is necessary to predict the hazard based on the effect of tsunami debris

Impact of COVID-19-Related Sports Activity Disruptions on the Physical Fitness of Japanese Adolescent Athletes

We assessed whether the coronavirus disease 2019 (COVID-19) pandemic-related disruptions impacted the physical fitness of adolescent athletes. We reviewed the age-, sex-, and sports category-matched data of 78 adolescent athletes (divided into two groups: 2019 group = 37; 2020 group = 41) from the clinical database and investigated their height, weight, body composition, flexibility muscle strength, and jump height. We also provided questionnaires to the teams’ coaches to collect data on the duration of practice suspension due to the COVID-19 pandemic; the practice hours per week in August 2019, immediately after the suspension ended, and in August 2020; and the guidelines for the players after resuming their practice. For data analyses, we considered p ≤ 0.05 as statistically significant. The strength of knee flexion and extension was significantly lower in the 2020 group than in the 2019 group; there was no difference in the other physical fitness parameters. The practice duration in August 2019 and August 2020 was the same. COVID-19-related interruptions did not alter the athletes’ jump height, upper-limb strength, and flexibility but reduced lower-limb muscle strength. We recommend that basic strength training protocols be followed to prevent sports-related injuries after such unexpected practice interruptions

Impact of COVID-19-Related Sports Activity Disruptions on the Physical Fitness of Japanese Adolescent Athletes

We assessed whether the coronavirus disease 2019 (COVID-19) pandemic-related disruptions impacted the physical fitness of adolescent athletes. We reviewed the age-, sex-, and sports category-matched data of 78 adolescent athletes (divided into two groups: 2019 group = 37; 2020 group = 41) from the clinical database and investigated their height, weight, body composition, flexibility muscle strength, and jump height. We also provided questionnaires to the teams’ coaches to collect data on the duration of practice suspension due to the COVID-19 pandemic; the practice hours per week in August 2019, immediately after the suspension ended, and in August 2020; and the guidelines for the players after resuming their practice. For data analyses, we considered p ≤ 0.05 as statistically significant. The strength of knee flexion and extension was significantly lower in the 2020 group than in the 2019 group; there was no difference in the other physical fitness parameters. The practice duration in August 2019 and August 2020 was the same. COVID-19-related interruptions did not alter the athletes’ jump height, upper-limb strength, and flexibility but reduced lower-limb muscle strength. We recommend that basic strength training protocols be followed to prevent sports-related injuries after such unexpected practice interruptions