MARKERS OF THE ENTERIC INFLAMMATION IN THE EVENT OF INTESTINAL DISEASES: LITERATURE REVIEW

The authors provided modern information on the basic noninvasive methods to assess the inflammatory process in the intestine in crohn's disease and colitis gravis. The researchers thoroughly described the opportunities and limitations for the use of faecal calprotectin as a marker of the inflammatory enteric diseases. Importance of this marker for the differential diagnostics of  the inflammatory and functional enteric diseases has been shown.Key words: markers of the enteric inflammation, faecal calprotectin, inflammatory bowel diseases, colitis gravis, сrohn's disease

MARKERS OF THE ENTERIC INFLAMMATION IN THE EVENT OF INTESTINAL DISEASES: LITERATURE REVIEW

The authors provided modern information on the basic noninvasive methods to assess the inflammatory process in the intestine in crohn's disease and colitis gravis. The researchers thoroughly described the opportunities and limitations for the use of faecal calprotectin as a marker of the inflammatory enteric diseases. Importance of this marker for the differential diagnostics of  the inflammatory and functional enteric diseases has been shown.Key words: markers of the enteric inflammation, faecal calprotectin, inflammatory bowel diseases, colitis gravis, сrohn's disease

FAECAL CALPROTECTIN IN NONINVASIVE DIAGNOSTICS OF THE INFLAMMATORY ENTERIC DISEASES AMONG CHILDREN

The authors studied the opportunities to define the level of faecal calprotectin in diagnostics of the inflammatory enteric diseases (grohn's disease and colitis gravis) among children. It was established that children, suffering from the inflammatory enteric diseases, the concentration of faecal calprotectin increases, thus, correlating with the clinical and endoscopic activity of the disease, as well as with the spread of the intestinal impairment. Faecal calprotectin may be a reliable marker of the inflammation activity in the event of grohn's disease and colitis gravis.Key words: faecal calprotectin, inflammatory enteric diseases, colitis gravis, grohn's disease, diagnostics, children

FAECAL CALPROTECTIN IN NONINVASIVE DIAGNOSTICS OF THE INFLAMMATORY ENTERIC DISEASES AMONG CHILDREN

The authors studied the opportunities to define the level of faecal calprotectin in diagnostics of the inflammatory enteric diseases (grohn's disease and colitis gravis) among children. It was established that children, suffering from the inflammatory enteric diseases, the concentration of faecal calprotectin increases, thus, correlating with the clinical and endoscopic activity of the disease, as well as with the spread of the intestinal impairment. Faecal calprotectin may be a reliable marker of the inflammation activity in the event of grohn's disease and colitis gravis.Key words: faecal calprotectin, inflammatory enteric diseases, colitis gravis, grohn's disease, diagnostics, children

ФЕКАЛЬНЫЙ КАЛЬПРОТЕКТИН В НЕИНВАЗИВНОЙ ДИАГНОСТИКЕ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ КИШЕЧНИКА У ДЕТЕЙ

The authors studied the opportunities to define the level of faecal calprotectin in diagnostics of the inflammatory enteric diseases (grohn's disease and colitis gravis) among children. It was established that children, suffering from the inflammatory enteric diseases, the concentration of faecal calprotectin increases, thus, correlating with the clinical and endoscopic activity of the disease, as well as with the spread of the intestinal impairment. Faecal calprotectin may be a reliable marker of the inflammation activity in the event of grohn's disease and colitis gravis.Key words: faecal calprotectin, inflammatory enteric diseases, colitis gravis, grohn's disease, diagnostics, children.Авторами изучены возможности использования определения уровня фекального кальпротектина в диагностике воспалительных заболеваний кишечника (болезни Крона и неспецифического язвенного колита) у детей. Установлено, что у детей с воспалительными заболеваниями кишечника концентрация фекального кальпротектина повышается, коррелируя с клинической и эндоскопической активностью болезни, а также с распространенностью поражения кишечника. Фекальный кальпротектин может служить надежным маркером активности воспаления при болезни крона и неспецифическом язвенном колите. Ключевые слова: фекальный кальпротектин, воспалительные заболевания кишечника, неспецифический язвенный колит, болезнь Крона, диагностика, дети.(Педиатрическая фармакология. – 2008;5(3):46-51

МАРКЕРЫ КИШЕЧНОГО ВОСПАЛЕНИЯ ПРИ ЗАБОЛЕВАНИЯХ КИШЕЧНИКА: ОБЗОР ЛИТЕРАТУРЫ

The authors provided modern information on the basic noninvasive methods to assess the inflammatory process in the intestine in crohn's disease and colitis gravis. The researchers thoroughly described the opportunities and limitations for the use of faecal calprotectin as a marker of the inflammatory enteric diseases. Importance of this marker for the differential diagnostics of  the inflammatory and functional enteric diseases has been shown.Key words: markers of the enteric inflammation, faecal calprotectin, inflammatory bowel diseases, colitis gravis, сrohn's disease.Представлена современная информация об основных неинвазивных методах оценки воспалительного процесса в кишечнике при болезни Крона и при неспецифическом язвенном колите. Подробно описаны возможности и ограничения использования фекального кальпротектина как маркера воспалительных заболеваний кишечника; в том числе как предиктора обострения заболевания, показателя эндоскопической ремиссии и восстановления слизистой оболочки кишечника, а также его значение для дифференциальной диагностики воспалительных и функциональных заболеваний кишечника.Ключевые слова: маркеры кишечного воспаления, фекальный кальпротектин, воспалительные заболевания кишечника, неспецифический язвенный колит, болезнь Крона. (Педиатрическая фармакология. – 2008;5(3):39-45