Feminist Social Justice Work: Moving Toward Solidarity

This article analyzes grassroots, feminist, and Freirean community-organizing as platforms for community-based service-learning (CBSL) and human rights work. CBSL is conceptualized as alignment, a first step in the long haul of working with community members in a solidarity relationship to create social justice

Therapeutic Neonatal Hepatic Gene Therapy in Mucopolysaccharidosis VII Dogs

Dogs with mucopolysaccharidosis VII (MPS VII) were injected intravenously at 2–3 days of age with a retroviral vector (RV) expressing canine β-glucuronidase (cGUSB). Five animals received RV alone, and two dogs received hepatocyte growth factor (HGF) before RV in an attempt to increase transduction efficiency. Transduced hepatocytes expanded clonally during normal liver growth and secreted enzyme with mannose 6-phosphate. Serum GUSB activity was stable for up to 14 months at normal levels for the RV-treated dogs, and for 17 months at 67-fold normal for the HGF/RV-treated dog. GUSB activity in other organs was 1.5–60% of normal at 6 months for two RV-treated dogs, which was likely because of uptake of enzyme from blood by the mannose 6-phosphate receptor. The body weights of untreated MPS VII dogs are 50% of normal at 6 months. MPS VII dogs cannot walk or stand after 6 months, and progressively develop eye and heart disease. RV- and HGF/RV-treated MPS VII dogs achieved 87% and 84% of normal body weight, respectively. Treated animals could run at all times of evaluation for 6–17 months because of improvements in bone and joint abnormalities, and had little or no corneal clouding and no mitral valve thickening. Despite higher GUSB expression, the clinical improvements in the HGF/RV-treated dog were similar to those in the RV-treated animals. This is the first successful application of gene therapy in preventing the clinical manifestations of a lysosomal storage disease in a large animal

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

\u27To love the little platoon\u27 : Edmund Burke\u27s Jacobite heritage

Not applicablePublisher version - http://www.irishacademicireland.com/acatalog/info_0716533650.html. DG 23/07/10 ti, ed, ke, de OR 3/9/1

Burke & the school of Irish oratory

The eighteenth-century traditions of Gaelic poetry and Trinity College Dublin’s academic focus on classical rhetoric are generally regarded as being two schools of thought that largely independent of each other. However, this article argues that Edmund Burke was one of those individuals who successfully drew from both these traditions in fashioning his own rhetorical practice. Burke had been stepped in Gaelic culture during the childhood years he spent living and being educated among his mother’s family, the Catholic Nagles of Cork’s Blackwater Valley and comparing Burke’s speeches (especially those that are considered original in thought or anomalous in the British canon) with Gaelic language poets we see how closely he drew from this tradition. This essay focuses more on the work of the rhetoricians of Trinity College and how Burke might be seen to have engaged with them in his treatise, A Philosophical Enquiry into the Origin of our Ideas on the Sublime and Beautiful, while noticing that his childhood exposure to Gaelic poetry through living with the Nagles continues to haunt even this most ‘enlightened’ of texts. The article further demonstrates that the Trinity men had theories of rhetoric that might be considered as a distinct school in that they were heavily influenced by each other’s work and were in strong divergence from John Locke’s most influential concepts.Not applicableNo electronic version. Link to journal homepage - http://www.isi.org/journals/burke_and_his_time.html. 23/07/10 ti.kpw6/10/1

St Patrick\u27s Day expulsions : race and homophobia in New York\u27s parade

Not applicableLink to publisher version - http://us.macmillan.com/irishpostmodernismsandpopularculture. DG 10/08/10 ti, ed, de OR 3/9/1

Aisling Ghear - A Terrible Beauty: The Gaelic Background to Burke\u27s Enquiry

Aisling Gheár - A Terrible Beauty was a poetic cliche in the Gaelic tradition by the time that Burke was composing his treatise on the Sublime and Beautiful. This article briefly summarises the Gaelic political and cultural background to Burke\u27s life and details how the genre of politcal poetry known as the Aisling Gheár might be seen to have influenced Burke\u27s Enquiry. The article is particularly interested in Burke\u27s focus on the effects of the Sublime and Beautiful on the psyche of the listener and the witness, and it draws on recently developing field of Cognitive Science’s exploration of Affect to discuss this aspect of Burke\u27s work

Edmund Burke\u27s political poetics

Not applicablePublisher version at: DG 09/08/10 ti ke SB. 27/8/1

Irish lesbian history : searching for sapphists

Not applicableSecond permission request sent 28/03/2011 - AV 5/04/201