589 research outputs found
Psychodynamic psychotherapy for children and adolescents: an updated narrative review of the evidence-base
While the evidence base for psychodynamic therapy with adults is now quite
substantial, there is still a lack of research evaluating the effectiveness of
psychodynamic therapies with children and young people. Those studies that have been
carried out are also not widely known in the field. To help address the second point, in
2011, we carried out a review of the evidence base for psychodynamic psychotherapy
for children and adolescents, which identified 35 studies which together provided some
preliminary evidence for this treatment for a range of childhood disorders. The present
study is an updated review, focusing on research published between March 2011 and
November 2016. During this period, 23 additional studies were published, of which 5
were reports on randomised controlled trials, 3 were quasi-experimental controlled
studies and 15 were observational studies. Although most studies covered children
with mixed diagnoses, there were a number of studies examining specific diagnostic
groups, including children with depression, anxiety and disruptive disorders. whilst
the quality of studies was mixed, some were well-designed and reported, and overall
indicated promising findings. Nevertheless, further high-quality research is needed
in order to better understand the effectiveness of psychodynamic psychotherapy
across a range of different disorders, and to ensure that services can provide a range of
evidence-based treatments for children and young people
Recommended from our members
Response of Two Lathrus Species to Infestation by the Pea Weevil, Bruchus pisorum L. (Coleoptera: Bruchidae)
Recommended from our members
Effect of Pollen Source on Oogenesis in Pea Weevil, Bruchus pisorum L. (Coleoptera: Bruchidae)
Recommended from our members
The Spider Fauna of Green Peas, Pisum sativum L., in Eastern Washington and Oregon, 1987
Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation
Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecular mechanisms that regulate midbrain dopaminergic axon growth and target innervation are less clear. Here we show that the transcription factor Zeb2 cell-autonomously represses Smad signalling to limit midbrain dopaminergic axon growth and target innervation. Zeb2 levels are downregulated in the embryonic rodent midbrain during the period of dopaminergic axon growth, when BMP pathway components are upregulated. Experimental knockdown of Zeb2 leads to an increase in BMP-Smad-dependent axon growth. Consequently there is dopaminergic hyperinnervation of the striatum, without an increase in the numbers of midbrain dopaminergic neurons, in conditional Zeb2 (Nestin-Cre based) knockout mice. Therefore, these findings reveal a new mechanism for the regulation of midbrain dopaminergic axon growth during central nervous system development
New Superhard Phases for 3D C60-based Fullerites
We have explored new possible phases of 3D C60-based fullerites using
semiempirical potentials and ab-initio density functional methods. We have
found three closely related structures - two body centered orthorhombic and one
body centered cubic - having 52, 56 and 60 tetracoordinated atoms per molecule.
These 3D polymers result in semiconductors with bulk moduli near 300 GPa, and
shear moduli around 240 GPa, which make them good candidates for new low
density superhard materials.Comment: To be published in Physical Review Letter
- …