Characteristics and treatment outcomes of HIV infected elderly patients enrolled in Kisii Teaching and Referral Hospital, Kenya

Background: A better understanding of the baseline characteristics of elderly people living with HIV/AIDS (PLWHA) is relevant because the world\u2019s HIV population is ageing. Objectives: This study aimed to evaluate the baseline characteristics of PLWHA aged 65 50years at recruitment to HIV/AIDS clinic compared against the viral load (VL) and CD4 count among patients attending Kisii Teaching and Referral Hospital (KTRH), Kenya. Methods: We retrospectively evaluated temporal inclinations of CD4 levels, viral load change and baseline demographic characteristics in the electronic records at the hospital using a mixed error-component model for 1329 PLWHA attending clinic between January 2008 and December 2019. Results: Findings showed a significant difference in the comparison between baseline VL and WHO AIDS staging (p=0.026). Overall VL levels decreased over the period significantly by WHO AIDS staging (p<0.0001). Significant difference was observed by gender (p<0.0001), across age groups (p<0.0001) and baseline CD4 counts (p=0.003). There were significant differences in WHO staging by CD4 count >200cell/mm3 (p=0.048) and residence (p=0.001). Conclusion: Age, WHO AIDS staging, gender and residence are relevant parameters associated with viral load decline and CD4 count in elderly PLWHA. A noticeable VL suppression was attained confirming possible attainment of VL suppression among PLWHA under clinical care

Effect of Environmental Exposure on the Lead Levels in Human Blood in Kenya

Lead is one of the heavy metals associated with a number of health problems such as abdominal pains, constipation and loss of appetite, nausea, vomiting, insomnia, headache, irritability, dizziness and lead encephalopathy. The major source of lead into the environment is through emission from auto exhaust in countries still using leaded fuel, with other contributors being cigarette smoke, burning of lead battery castings, weathering, ceramic industries and paints. Therefore there is need for continued monitoring of the levels of lead in the environment and in people to determine the level of exposure. The aim of the study was to determine the effect of environmental exposure on the levels of lead in human blood in Nairobi City and Nyamira District, Kenya. The subjects who had lived in the study areas continuously for five years were randomly selected and recruited for the study. The study used a questionnaire to assess lead exposure factors of the recruits, while atomic absorption spectroscopy and differential pulse anodic stripping voltammetry were used for determining the lead levels. The subjects in Nairobi City Centre had the highest mean blood lead (BPb) level of 29.9 + 16.91 µg/l, while Nyamira Rural subjects had the lowest mean of 24.20 + 7.07 µg/l. The mean lead level of the subjects was statistically significant between Nairobi City Centre and Nyamira Rural (P < 0.01, df = 99). The smokers, those who travelled frequently, the users of glazed ceramics, those who worked in industries and those who lived near busy roads had higher levels of blood lead. The study provides an additional data pointing to elevated blood lead levels in environmentally exposed individuals. Keywords: Lead, environmental exposure, human blood, AAS, DPASV.

Effect of Occupation on the Levels of Lead in Human Blood in Kenya

The occupation an individual is involved in exposes him or her to different levels of lead from the work environment. The main occupation of the study subjects included working in the petrol stations, teaching, nursing, street hawking, doing clerical work, working in public vehicles, farming and schooling. The aim of the study was to determine the effect of occupation on the lead levels in human blood in Nairobi City and Nyamira District, Kenya. The subjects involved in the different occupations were randomly selected and recruited for the study. The study used a questionnaire to assess lead exposure factors of the recruits, while atomic absorption spectroscopy and differential pulse anodic stripping voltammetry were used for determining the lead levels. The street hawkers in Nairobi City centre had the highest mean blood lead level of 36.85?16.98 ?g/ dl while the teachers of Nyamira Town had the lowest mean blood lead level of 8.1?5.3 ?g/ dl. The study provides an additional data pointing to elevated blood lead levels in occupationally exposed individuals. Key words: Occupational exposure, BPb, AAS, DPASV