Measurement of the proton light response of various LAB based scintillators and its implication for supernova neutrino detection via neutrino-proton scattering

The proton light output function in electron-equivalent energy of various scintillators based on linear alkylbenzene (LAB) has been measured in the energy range from 1 MeV to 17.15 MeV for the first time. The measurement was performed at the Physikalisch-Technische Bundesanstalt (PTB) using a neutron beam with continuous energy distribution. The proton light output data is extracted from proton recoil spectra originating from neutron-proton scattering in the scintillator. The functional behavior of the proton light output is described succesfully by Birks' law with a Birks constant kB between (0.0094 +/- 0.0002) cm/MeV and (0.0098 +/- 0.0003) cm/MeV for the different LAB solutions. The constant C, parameterizing the quadratic term in the generalized Birks law, is consistent with zero for all investigated scintillators with an upper limit (95% CL) of about 10^{-7} cm^2/MeV^2. The resulting quenching factors are especially important for future planned supernova neutrino detection based on the elastic scattering of neutrinos on protons. The impact of proton quenching on the supernova event yield from neutrino-proton scattering is discussed.Comment: 12 pages, 17 figures, 4 tables, updated version for publication in Eur.Phys.J.

Comparison of Methods to Determine the Fluence of Monoenergetic Neutrons in the Energy Range from 30 keV to 14.8 MeV

The primary reference instruments for neutron fluence measurements used at the Physikalisch-Technische Bundesanstalt (PTB) are based on the primary standard for neutron measurements which is the differential neutron-proton scattering cross section. Such instruments require considerable effort for their operation and analysis. Therefore, routine measurements are carried out using a transfer instrument to facilitate the efficient provision of services to customers. A series of measurements was conducted to compare the transfer device to the primary reference instruments and ensure the traceability of neutron fluence measurements. This resulted in an improved characterization of the instrument and new analysis procedures

Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia

Background: Molecular mechanisms regulating leukocyte sequestration into the tissue during endotoxemia and/or sepsis are still poorly understood. This in vivo study investigates the biological role of murine PECAM-1 and VCAM-1 for leukocyte sequestration into the lung, liver and striated skin muscle. Methods: Male BALB/c mice were injected intravenously with murine PECAM-1 IgG chimera or monoclonal antibody (mAb) to VCAM-1 ( 3 mg/kg body weight); controls received equivalent doses of IgG2a ( n = 6 per group). Fifteen minutes thereafter, 2 mg/kg body weight of Salmonella abortus equi endotoxin was injected intravenously. At 24 h after the endotoxin challenge, lungs, livers and striated muscle of skin were analyzed for their myeloperoxidase activity. To monitor intravital leukocyte-endothelial cell interactions, fluorescence videomicroscopy was performed in the skin fold chamber model of the BALB/c mouse at 3, 8 and 24 h after injection of endotoxin. Results: Myeloperoxidase activity at 24 h after the endotoxin challenge in lungs (12,171 +/- 2,357 mU/g tissue), livers ( 2,204 +/- 238 mU/g) and striated muscle of the skin ( 1,161 +/- 110 mU/g) was significantly reduced in both treatment groups as compared to controls, with strongest attenuation in the PECAM-1 IgG treatment group. Arteriolar leukocyte sticking at 3 h after endotoxin (230 +/- 46 cells x mm(-2)) was significantly reduced in both treatment groups. Leukocyte sticking in postcapillary venules at 8 h after endotoxin ( 343 +/- 69 cells/mm(2)) was found reduced only in the VCAM-1-mAb-treated animals ( 215 +/- 53 cells/mm(2)), while it was enhanced in animals treated with PECAM-1 IgG ( 572 +/- 126 cells/mm(2)). Conclusion: These data show that both PECAM-1 and VCAM-1 are involved in endotoxin-induced leukocyte sequestration in the lung, liver and muscle, presumably through interference with arteriolar and/or venular leukocyte sticking. Copyright (C) 2004 S. Karger AG, Basel

Bulk Observers in Non-Factorizable Geometries

We consider five dimensional non-factorizable geometries where the transverse dimension is bounded and the remaining (parallel) dimensions are not. We study the construction of effective theories at distances much longer than the transverse size. An observer unable to resolve the transverse direction can only measure distances along the parallel dimensions, but the non-factorizable geometry makes the length of a curve along the parallel dimension sensitive to where on the transverse direction the curve lies. We show that long geodesics that differ in their endpoints only by shifts along the transverse direction all have the same length to within the observer's resolution. We argue that this is the correct notion of distance in the effective theory for a bulk observer. This allows us to present a consistent interpretation of what is measured by observers that live either on a brane or in the bulk