Extended collimator model for pencil-beam dose calculation in proton radiotherapy

We have developed a simple collimator model to improve the accuracy of penumbra behaviour in pencil-beam dose calculation for proton radiotherapy. In this model, transmission of particles through a three-dimensionally extended opening of a collimator is calculated in conjunction with phase-space distribution of the particles. Comparison of the dose distributions calculated using the new three-dimensional collimator model and the conventional twodimensional model to lateral dose profiles experimentally measured with collimated proton beams showed the superiority of the new model over the conventional one

胸部特異的肋骨形成における組織間相互作用とその分子機構

研究期間:平成14-17年度 ; 研究種目: 基盤研究B ; 課題番号:14370006原著には既発表論文の別刷を含む

A Distinct Role of the Queen in Coordinated Workload and Soil Distribution in Eusocial Naked Mole-Rats

We investigated how group members achieve collective decision-making, by considering individual intrinsic behavioural rules and behavioural mechanisms for maintaining social integration. Using a simulated burrow environment, we investigated the behavioural rules of coordinated workload for soil distribution in a eusocial mammal, the naked mole-rat (Heterocephalus glaber). We tested two predictions regarding a distinct role of the queen, a socially dominant individual in the caste system: the presence of a queen would increase the workload of other caste individuals, and the cues by a queen would affect the soil distribution. In experiment 1, we placed four individuals of various castes from the same colony into an experimental burrow. Workers exhibited the highest frequency of workload compared to other castes. The presence of a queen activated the workload by other individuals. Individuals showed a consistent workload in a particular direction so as to bias the soil distribution. These results suggest that individuals have a consensus on soil distribution and that the queen plays a distinct role. In experiment 2, we placed the odour of a queen in one of four cells and observed its effect on other individuals’ workload and soil distribution. Relative to other cells, individuals frequently dug in the queen cell so the amount of soil in the queen cell decreased. These results suggest that queen odour is an important cue in coordinated workload and soil distribution in this species

ASTE CO(3-2) Observations of the Barred Spiral Galaxy M 83: I. Correlation between CO(3-2)/CO(1-0) Ratios and Star Formation Efficiencies

We present CO(J=3-2) emission observations with the Atacama Submillimeter Telescope Experiment (ASTE) toward the 5' x 5' (or 6.6 x 6.6 kpc at the distance D = 4.5 Mpc) region of the nearby barred spiral galaxy M 83. We successfully resolved the major structures, i.e., the nuclear starburst region, bar, and inner spiral arms in CO(J=3-2) emission at a resolution of 22'' (or 480 pc), showing a good spatial coincidence between CO(J=3-2) and 6 cm continuum emissions. We found a global CO(J=3-2) luminosity L'_CO(3-2) of 5.1 x 10^8 K km s^-1 pc^2 within the observed region. We also found L'_CO(3-2) in the disk region (0.5 < r < 3.5 kpc) of 4.2 x 10^8 K km s^-1 pc^2, indicating that CO(J=3-2) emission in the disk region significantly contributes to the global L'_CO(3-2). From a comparison of a CO(J=3-2) data with CO(J=1-0) intensities measured with Nobeyama 45-m telescope, we found that the radial profile of CO(J=3-2)/CO(J=1-0) integrated intensity ratio R_3-2/1-0 is almost unity in the central region (r < 0.25 kpc), whereas it drops to a constant value, 0.6--0.7, in the disk region. The radial profile of star formation efficiencies (SFEs), determined from 6 cm radio continuum and CO(J=1-0) emission, shows the same trend as that of R_3-2/1-0. At the bar-end (r ~ 2.4 kpc), the amounts of molecular gas and the massive stars are enhanced when compared with other disk regions, whereas there is no excess of R_3-2/1-0 and SFE in that region. This means that a simple summation of the star forming regions at the bar-end and the disk cannot reproduce the nuclear starburst of M 83, implying that the spatial variation of the dense gas fraction traced by R_3-2/1-0 governs the spatial variation of SFE in M 83.Comment: 13 pages, 11 figures, PASJ in press, version with high resolution figures is available via http://www.nro.nao.ac.jp/~z5001km/m83-aste.pd

Analysis of the Complete Open Reading Frame of Genotype 2b Hepatitis C Virus in Association with the Response to Peginterferon and Ribavirin Therapy

BACKGROUND AND AIMS: Patients infected with genotype 2b hepatitis C virus (HCV) generally can achieve favorable responses to pegylated-interferon plus ribavirin therapy (PEG-IFN/RBV). However, a proportion of patients show poorer responses and the correlation between viral sequence variation and treatment outcome remains unclear. METHODS: The pretreatment complete open reading frame (ORF) sequences of genotype 2b HCV determined by direct sequencing were investigated for correlation with the final outcome in a total of 60 patients. RESULTS: In this study group, 87.5% (14/16) of non-sustained virological response (non-SVR) patients (n = 16) were relapsers. Compared to sustained virological response (SVR) patients (n = 44), non-SVR patients were older and could not achieve prompt viral clearance after the therapy induction. Comparing each viral protein between the two groups, viral sequences were more diverse in SVR patients and that diversity was found primarily in the E1, p7, and NS5A proteins. In searching for specific viral regions associated with the final outcome, several regions in E2, p7, NS2, NS5A, and NS5B were extracted. Among these regions, part of the interferon sensitivity determining region (ISDR) was included. In these regions, amino acid substitutions were associated with the final outcome in an incremental manner, depending upon the number of substitutions. CONCLUSIONS: Viral sequences are more diverse in SVR patients than non-SVR patients receiving PEG-IFN/RBV therapy for genotype-2b HCV infection. Through systematic comparison of viral sequences, several specific regions, including part of the ISDR, were extracted as having significant correlation with the final outcome