47 research outputs found
Current Developments in Intraspinal Agents for Cancer and Noncancer Pain
Since the late 1980s, intrathecal (IT) analgesic therapy has improved, and implantable IT drug delivery devices have become increasingly sophisticated. Physicians and patients now have myriad more options for agents and their combination, as well as for refining their delivery. As recently as 2007, The Polyanalgesic Consensus Conference of expert panelists updated its algorithm for drug selection in IT polyanalgesia. We review this algorithm and the emerging therapy included. This article provides an update on newly approved as well as emerging IT agents and the advances in technology for their delivery
Effects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind-limb ischemia/reperfusion injury
The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis
Protective effect of N-acetylcysteine on kidney as a remote organ after skeletal muscle ischemia-reperfusion
2015/16 seasonal vaccine effectiveness against hospitalisation with influenza a(H1N1)pdm09 and B among elderly people in Europe: Results from the I-MOVE+ project
We conducted a multicentre test-negative caseâ\u80\u93control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged â\u89¥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases
Thrombin inhibition with melagatran does not attenuate renal ischaemia-reperfusion injury in rats
Meniscal tears left in situ during anatomic single bundle anterior cruciate ligament reconstruction
Abstract. – OBJECTIVES: Anterior cruciate
ligament (ACL) injuries are a common finding in
sports medicine. Our scope is to investigate
whether stable, incomplete medial meniscus
tears could be left untreated during single bundle
anatomic anterior cruciate ligament reconstruction.
PATIENTS AND METHODS: A prospective observational
study on 597 knees from a single
surgeon cohort, using the same reconstruction
technique, found 23 medial and 48 lateral meniscus
tears which could be left untreated.
RESULTS: None of the cases required reintervention
during the first postoperative year. In
fact, 21.7% of the medial meniscus group and
14.6% of the lateral group had potential residual
symptoms that were not confirmed and gradually
disappeared within one year. A comparison of
Cincinnati Knee, IKDC scores and limb symmetry
index values (calculated using the triple hop
for distance into the two groups) found no differences
for the last two variables (both p = 0.065)
and was marginal for the first score (p < 0.05).
The between groups comparisons, performed in
the KT-1000, also yielded no difference (p = 0.11).
CONCLUSIONS: We than concluded that incomplete
meniscal tears, left in situ at the time of anterior
cruciate ligament reconstruction, could have
favorable outcomes as long as decisions are carefully
weighed with regard to the length of the lesion.
Also, at least in this perspective, anatomic
single bundle has proved a sufficient stabilizer for
anterior translation of the tibia
Carpal tunnel release: transverse or longitudinal limited-incisions?
Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy of the upper extremity. Surgical decompression through a limited open palmar incision is still the most widely used treatment. The aim of this study was to compare two different incision surgical techniques for carpal tunnel surgery