Subgingival Curettage Versus Surgical Elimination of Periodontal Pockets

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142057/1/jper0167.pd

Short Term Results of Three Modalities of Periodontal Treatment

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141914/1/jper0131.pd

Longitudinal Study of Periodontal Therapy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142010/1/jper0066.pd

Results Following Three Modalities of Periodontal Therapy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141627/1/jper0522.pd

Results of Periodontal Treatment Related to Pocket Depth and Attachment Level. Eight Years

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141007/1/jper0225.pd

Radiographs in Clinical Periodontal Trials

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141530/1/jper0381.pd

Effect of Periodontal Treatment on Tooth Mobility

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141245/1/jper0635.pd

Oral Hygiene and Maintenance of Periodontal Support

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142220/1/jper0026.pd

Four modalities of periodontal treatment compared over five years

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65517/1/j.1600-0765.1987.tb01573.x.pd

Identification and Characterization of Microcin S, a New Antibacterial Peptide Produced by Probiotic Escherichia coli G3/10

Escherichia coli G3/10 is a component of the probiotic drug Symbioflor 2. In an in vitro assay with human intestinal epithelial cells, E. coli G3/10 is capable of suppressing adherence of enteropathogenic E. coli E2348/69. In this study, we demonstrate that a completely novel class II microcin, produced by probiotic E. coli G3/10, is responsible for this behavior. We named this antibacterial peptide microcin S (MccS). Microcin S is coded on a 50.6 kb megaplasmid of E. coli G3/10, which we have completely sequenced and annotated. The microcin S operon is about 4.7 kb in size and is comprised of four genes. Subcloning of the genes and gene fragments followed by gene expression experiments enabled us to functionally characterize all members of this operon, and to clearly identify the nucleotide sequences encoding the microcin itself (mcsS), its transport apparatus and the gene mcsI conferring self immunity against microcin S. Overexpression of cloned mcsI antagonizes MccS activity, thus protecting indicator strain E. coli E2348/69 in the in vitro adherence assay. Moreover, growth of E. coli transformed with a plasmid containing mcsS under control of an araC PBAD activator-promoter is inhibited upon mcsS induction. Our data provide further mechanistic insight into the probiotic behavior of E. coli G3/10