Recurrent venous thromboembolism after discontinuation of rivaroxaban therapy in a patient with antiphospholipid syndrome

A Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombembolic events including thromboembolism (VTE) in association with the presence of antiphospholipid antibodies. The standard treatment of VTE historically consists of anticoagulation therapy with warfarin, a vitamin K antagonist. Recently, direct oral anticoagulants, including rivaroxaban have become available for the treatment of VTE. However, the choice of anticoagulant, and the duration of anticoagulation in patients with APS has not been determined yet due to lack of evidence. Here, we report a case of recurrent venous thrombosis after discontinuation of rivaroxaban therapy and avoiding sedentary life style in a patient with APS. We suggest that indefinite anticoagulation therapy might be needed even in low risk APS cases

Desingularization of matrix equations employing hypersingular integrals in boundary element methods using double nodes

In boundary element methods, the method of using double nodes at corners is a useful approach to uniquely define the normal direction of boundary elements. However, matrix equations constructed by conventional boundary integral equations (CBIE) become singular under certain combinations of double node boundary conditions. In this paper, we analyze the singular conditions of the CBIE formulation for cases where the boundary conditions at the double node are imposed by combinations of Dirichlet, Neumann, Robin, and interface conditions. To address this singularity we propose the use of hypersingular integral equations (HBIE) for wave propagation problems that obey Helmholtz equation. To demonstrate the applicability of HBIE, we compare three types of simultaneous equations: (i) CBIE, (ii) partial-HBIE in which HBIE is only applied to the double nodes at corners while CBIE is applied to the other nodes, and (iii) full-HBIE in which HBIE is applied to all nodes. Based on our numerical results, we observe the following results. The singularity of the matrix equations for problems with any combination of boundary conditions can be resolved by both full-HBIE and partial-HBIE, and partial-HBIE exhibits better accuracy than full-HBIE. Furthermore, the computational cost of partial-HBIE is smaller than that of full-HBIE.Comment: 14 pages, 10 figures, accepted manuscript submitted to Engineering Analysis with Boundary Elemen

Osteolytic bone lymphoma

Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive bone lesions such as those of the femur or pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL can be underdiagnosed because patients do not experience symptoms or show objective abnormalities in the early stage. Here, we reported an elderly patient with PBL in multiple bones, including the cranial and femoral bones that were fractured due to falling

Analytical regularization of hypersingular integral for Helmholtz equation in boundary element method

This paper presents a gradient field representation using an analytical regularization of a hypersingular boundary integral equation for a 2-dimensional time harmonic wave equation called the Helmholtz equation. The regularization is based on cancelation of the hyper-singularity by considering properties of hypersingular elements that are adjacent to a singular node. Advantages to this regularization include applicability to evaluate cornet nodes, no limitation for element size, and reduced computational cost compared to other methods. To demonstrate capability and accuracy, regularization is estimated for a problem about plane wave propagation. As a result, it is found that even at a corner node the most significant error in the proposed method is due to truncation error of non-singular elements in discretization, and error from hypersingular elements is negligibly small

Phase unwrapping for noisy phase map using localized compensator

Phase unwrapping for a noisy image suffers from many singular points. Singularity-spreading methods are useful for the noisy image to regularize the singularity. However, the methods have a drawback of distorting phase distribution in a regular area that contains no singular points. When the singular points are confined in some local areas, the regular region is not distorted. This paper proposes a new phase unwrapping algorithm that uses a localized compensator obtained by clustering and by solving Poisson's equation for the localized areas. The numerical results demonstrate that the proposed method can improve the accuracy compared with other singularity-spreading methods

Reliable phase unwrapping algorithm based on rotational and direct compensators

Phase unwrapping still plays an important role in many data-processing chains based on phase information. Here, we introduce a new phase unwrapping approach for noisy wrapped phase maps of continuous objects to improve the accuracy and computational time requirements of phase unwrapping using a rotational compensator (RC) method. The proposed algorithm is based on compensating the singularity of discontinuity sources. It uses direct compensation for adjoining singular point (SP) pairs and uses RC for other SP pairs. The performance of the proposed method is tested through both simulated and real wrapped phase data. The proposed algorithm is faster than the original algorithm with the RC and has proved efficiency compared to other phase unwrapping methods

Observation of(1)D-(1)Sforbidden optical emission of atomic oxygen in atmospheric-pressureN(2)/O(2)plasma jet

We observed green optical emission from an atmospheric-pressureN(2)/O(2)plasma jet. The green optical emission was composed of a line emission at lambda = 557.71 +/- 0.03 nmand a broadband component at530 <= lambda <= 560 nm. The line emission was assigned to the(1)D-(1)Sforbidden transition of atomic oxygen, whereas the broadband emission was due to the formation ofO(S-1)N(2)excimer. We measured the absolute densities ofO(S-1)andO(S-1)N(2)using a spectrograph with the absolute sensitivity calibration, and we discussed the kinetics in the green plasma jet on the basis of the absoluteO(S-1)andO(S-1)N(2)densities. According to the rate coefficients and the transition probabilities reported in literature, the present experimental results are explained if the densities ofN2(A3 n-ary sumation u+)andO(P-3)are9 x 10(13)and3 x 10(13)cm(-3), respectively

Density distributions of OH, Na, water vapor, and water mist in atmospheric-pressure dc helium glow plasmas in contact with NaCl solution

This paper reports the density distributions of OH, Na, water vapor and water mist in atmospheric-pressure dc helium glow plasmas in contact with NaCl solution. The densities of OH, Na and H2O had different spatial distributions, while the Na density had a similar distribution to mist, suggesting that mist is the source of Na in the gas phase. When the flow rate of helium toward the electrolyte surface was increased, the distributions of all the species densities concentrated in the neighboring region to the electrolyte surface more significantly. The densities of all the species were sensitive to the electric polarity of the power supply. In particular, we never detected Na and mist when the electrolyte worked as the anode of the dc discharge

Comparison among translational temperatures of He(P-1(1)o), He(S-3(1)), and Ar(4s [3/2](2)(o)) in inductively coupled plasmas

We compared the translational temperatures of He(P-1(1)o), He(S-3(1)), and Ar(4s [3/2](2)(o)) in low-pressure inductively coupled plasmas. We employed laser absorption spectroscopy for measuring the Doppler broadening widths of the transition lines, and they told us the translational temperatures of the three electronic excited states. From the comparison between the temperatures of He(P-1(1)o) and He(S-3(1)), we confirmed that the metastable S-3(1) state can work as the probe for the temperature measurement of the ground state helium atoms. We observed higher temperatures for Ar(4s [3/2](2)(o)) than He(S-3(1)) in helium-argon mixture plasmas with total pressures less than 80 mTorr. The higher Ar(4s [3/2](2)(o)) temperature is considered to be due to the selective heating of argon by the charge exchange collision with Ar+

Estimation of sheath electric field in inductively coupled hydrogen plasma on the basis of Doppler-broadened absorption spectrum of hydrogen Balmer-alpha line

We examined the applicability of the Doppler-broadened absorption spectrum of the hydrogen Balmer-alpha line to the estimation of the sheath electric field in plasma. The Stark splitting of the fine-structure components was calculated by solving the time-independent Schrodinger equation at various electric field strengths, and the theoretical absorption spectrum was obtained by the superposition of the fine-structure components with the same Doppler broadening widths. The spectrum of the Balmer-alpha line of atomic hydrogen, which was measured by standard diode laser absorption spectroscopy, was fitted with the theoretical spectrum. We succeeded in determining the translational temperature of atomic hydrogen, which was obtained from the Doppler broadening width, and the electric field strength by the spectral fitting. We have evaluated that the minimum electric field strength that can be detected by the present method is approximately 350 V cm(-1) when the translational temperature of atomic hydrogen is 400-500 K