16 research outputs found

    Quantifying the effects of external factors on the behavior of vertical wicking in a warp stretch woven fabric

    No full text
    Wicking ability of textiles is a key indicator in determining the physiological comfort provided by a fabric. The property is shaped by various factors internal and external to the fabric. Herein, the effects of some external factors such as the degree of (fabric) extension, the wetting liquid’s temperature and relative humidity on the vertical wicking behavior of a previously prepared warp stretch woven fabric were investigated. The fabric, which could be reversibly extended up to 60%, was prepared using a nylon/spandex air-covered yarn in the warp and cotton yarn in the weft. The results indicated that these external factors had a great influence on the vertical wicking equilibrium height with the degree of fabric extension having a more pronounced effect compared with the other two factors. Furthermore, extension and relative humidity were negatively related to the height of the vertical wicking, whilst an increase in liquid temperature resulted in an increase in vertical wicking height. The underlying mechanisms associated with these effects were examined using a specially constructed test chamber and tensioning device. The experimental data were also verified using the classical Laughlin-Davies model, and the results demonstrated the proposed wicking model could be used to predict the changes in fabric wicking height. These findings provide a more in-depth understanding of the wicking behavior of stretchable textiles in a comprehensive and objective manner

    Ueber die raeumliche Verteilung der Magnesium-Atome und -Ionen in einer Helium-Glimmentladung mit Magnesium-Kathode Eine Untersuchung mit Laser-induzierter Fluoreszenz

    No full text
    SIGLEAvailable from TIB Hannover: RA 831(2484) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

    Metabolomics analysis of serum in a rat heroin self-administration model undergoing reinforcement based on 1H-nuclear magnetic resonance spectra

    No full text
    Abstract Background Understanding the process of relapse to abused drugs and ultimately developing treatments that can reduce the incidence of relapse remains the primary goal for the study of substance dependence. Therefore, exploring the metabolite characteristics during the relapse stage is valuable. Methods A heroin self-administered rat model was employed, and analysis of the 1H-nuclear magnetic resonance-based metabolomics was performed to investigate the characteristic metabolite profile upon reintroduction to the drug after abstinence. Results Sixteen metabolites in the serum of rats, including phospholipids, intermediates in TCA (Tricarboxylic Acid Cycle) cycle, keto bodies, and precursors for neurotransmitters, underwent a significant change in the reinstatement stage compared with those in the control group. In particular, energy production was greatly disturbed as evidenced by different aspects such as an increase in glucose and decrease in intermediates of glycolysis and the TCA cycle. The finding that the level of 3-hydroxybutyrate and acetoacetate increased significantly suggested that energy production was activated from fatty acids. The concentration of phenylalanine, glutamine, and choline, the precursors of major neurotransmitters, increased during the reinstatement stage which indicated that an alteration in neurotransmitters in the brain might occur along with the disturbance in substrate supply in the circulatory system. Conclusions Heroin reinforcement resulted in impaired energy production via different pathways, including glycolysis, the TCA cycle, keto body metabolism, etc. A disturbance in the substrate supply in the circulatory system may partly explain heroin toxicity in the central nervous system. These findings provide new insight into the mechanism underlying the relapse to heroin use

    An Expeditious Neutralization Assay for Porcine Reproductive and Respiratory Syndrome Virus Based on a Recombinant Virus Expressing Green Fluorescent Protein

    No full text
    Due to the extensive genetic and antigenic variation in Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), as well as its rapid mutability and evolution, PRRS prevention and control can be challenging. An expeditious and sensitive neutralization assay for PRRSV is presented to monitor neutralizing antibodies (NAbs) in serum during vaccine research. Here, a PRRSV expressing eGFP was successfully rescued with reverse genetics based on the infectious clone HuN4-F112-eGFP which we constructed. The fluorescent protein expressions of the reporter viruses remained stable for at least five passages. Based on this reporter virus, the neutralization assay can be easily used to evaluate the level of NAbs by counting cells with green fluorescence. Compared with the classical CPE assay, the newly developed assay increases sensitivity by one- to four-fold at the early antibody response stage, thus saving 2 days of assay waiting time. By using this assay to unveil the dynamics of neutralizing antibodies against PRRSV, priming immunity through either a single virulent challenge or only vaccination could produce limited NAbs, but re-infection with PRRSV would induce a faster and stronger NAb response. Overall, the novel HuN4-F112-eGFP-based neutralization assay holds the potential to provide a highly efficient platform for evaluating the next generation of PRRS vaccines
    corecore