Postprandial TG and apoB48 in plasma and in lipoprotein subclasses stratified by SULF2 rs2281279 genotype.

<p>Carriers of the G allele had lower AUC for plasma TG (A) and TG content of VLDL1 (C) and VLDL2 (D) than AA homozygotes; the chylomicron TG content (B) did not differ between the different genotype carriers. Carriers of the G allele had lower AUC for apoB48 content of chylomicrons (F) and VLDL1 (G) than AA homozygotes; the apoB48 content in plasma (E) and VLDL2 (H) did not differ between the genotype groups. Data are shown as median (interquartile range). <i>P</i> values were calculated by linear regression adjusting for age, gender and body mass index (BMI). All the data is specified in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079473#pone.0079473.s005" target="_blank">Table S5</a>. The number of subjects is given at the bottom of each column. AA, subjects with two A alleles; AG, heterozygotes; GG, subjects with two G alleles.</p

Relative importance analysis.

<p>Contribution of each variable for explaining (A) the plasma TG AUC (B) the TG-chylomicron AUC and (C) the apoB48 AUC after the fat-rich meal. For every plot 15 variables are shown. Ten variables including GLP-1, GLP-2 and GIP (to the left in each plot) are shared between (A), (B) and (C). Five variables to the right hand side in the graphs vary between (A), (B) and (C). These five were chosen as they correlate most strongly with the response variable in question and thus provide a relative importance reference to the other ten variables.</p

Responses of glucose, insulin, GLP-1, GLP-2 and GIP after fat-rich meal (open circles) and OGTT (black circles).

<p>Data show mean ± SEM. Stars indicate significant (p-value < 0.05) difference between fat-rich meal and OGTT for a given time point.</p

Correlation between incretins and postprandial lipid responses.

<p>Correlations between areas under curve (AUC) for GLP-1, GLP-2 and GIP with plasma TG, apoB48 in the chylomicron fraction, and triglycerides in the chylomicron fraction after the fat-rich meal.</p