Introducing Protein Homeostasis and Glycogen Synthesis as Two Targets of Blue Light Radiation in Lentinula edodes

Introduction: There are documents about biological effects of blue light radiation on different organisms. Molecular mechanism understanding of radiation effects on biological samples is an important event which attracted attention of researchers. Determining of the critical dysregulated proteins of Lentinula edodes following blue light radiation is the aim of this study. Methods: Number of 22 differentially expressed proteins of Lentinula edodes in response to 300 lux of blue light were extracted from literature. Experimental, text mining, and co-expression connections between the queried proteins were assessed via STRING database. The maps were compared and the critical proteins were identified. Results: Among the 21 queried proteins, six individuals including; heat shock HSP70 protein, 20S proteasome subunit, 26S proteasome subunit P45, Aspartate aminotransferase, Phosphopyruvate hydratase, and Phosphoglucomutase were highlighted as the critical proteins in response to blue light radiation.   Conclusion: Finding indicates that protein homeostasis and glycogen synthesis are affected by blue light radiation.   &nbsp

Assessment of Immunological Effects of Low-Level Er: YAG Laser Radiation

Introduction: Low-level laser radiation have a significant effect on cell proliferation. Various investigations about effect of Er: YAG laser on the treated cell lines are published. Determining of core targeted proteins is an attractive subject. Aim of this research is identifying the critical targeted protein by low-level Er: YAG laser in Primary Osteoblast-like Cells. Methods: Data was extracted from literature about proteomic assessment of 3.3 J/cm2 of low-level Er: YAG laser radiation on osteoblast-like cells of rat calvaria. The significant differentially expressed proteins (DEPs) plus 100 first neighbors were analyzed via network analysis and gene ontology enrichment.   Results: Numbers of 9 DEPs among the 12 queried proteins were included in the main connected component. Analysis revealed that Cxcl1 is a key targeted protein in response to laser radiation. Presence of Cxcl1 in the significant cellular pathways indicates that cell growth and proliferation are affected.    Conclusion: It can be concluded that Immune system is affected by laser to activate cellular defend against stress