Rapid development of bromodomain probes using flow synthesis methods and frontal affinity chromatography

<p>This poster illustrates aspects of a project involving the development of new probes for bromodomain 9 protein.</p> <p>Flow chemistry technologies and remote monitoring techniques were used for the synthesis, and Frontal Affinity Chromatography assays were used for analysis of the products.</p

A “Catch-React-Release” method for the flow synthesis of 2-aminopyrimidines and preparation of the imatinib base

<p>This poster illustrates the development of a monolith-supported synthetic procedure for of 2-aminopyrimidine derivatives. The process was applied to a key precursor to imatinib (Gleevec) an important anti-cancer drug.</p> <p>Also described are automation techniques used for control of the flow chemistry devices during the synthesis.</p> <p>This work is published in <em>Organic Letters</em>.</p