Erratum to: Calculations for deep inelastic scattering using fast interpolation grid techniques at NNLO in QCD and the extraction of αs\alpha _{\mathrm {s}} from HERA data

The implementation of interpolation grid techniques at NNLO and their subsequent application to the extraction of the strong coupling constant α s αs presented in Ref. [1] are based on the calculation in the framework [2,3,4]. An implementation error was found in this calculation [4] that altered the predicted cross sections for the DIS process at NNLO. While technical aspects and equations remain unchanged, reported numerical values and the extracted value of α s αs are affected. Updated figures, tables, and numbers quoted in the main text that have changed are provided. Numbering of sections and figures is as in Ref. [1]

Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Dominant mutations in five tRNA synthetases cause Charcot–Marie–Tooth (CMT) neuropathy, suggesting that altered aminoacylation function underlies the disease. However, previous studies showed that loss of aminoacylation activity is not required to cause CMT. Here we present a Drosophila model for CMT with mutations in glycyl-tRNA synthetase (GARS). Expression of three CMT-mutant GARS proteins induces defects in motor performance and motor and sensory neuron morphology, and shortens lifespan. Mutant GARS proteins display normal subcellular localization but markedly reduce global protein synthesis in motor and sensory neurons, or when ubiquitously expressed in adults, as revealed by FUNCAT and BONCAT. Translational slowdown is not attributable to altered tRNA[superscript Gly] aminoacylation, and cannot be rescued by Drosophila Gars overexpression, indicating a gain-of-toxic-function mechanism. Expression of CMT-mutant tyrosyl-tRNA synthetase also impairs translation, suggesting a common pathogenic mechanism. Finally, genetic reduction of translation is sufficient to induce CMT-like phenotypes, indicating a causal contribution of translational slowdown to CMT.National Institutes of Health (U.S.) (Grant GM17151

An Ultra-Fast and Wide-Spectrum Linear Array Detector for High Repetition Rate and Pulsed Experiments

Photon science research at accelerators is influenced radically by the developments of sensor and readout technologies for imaging. These technologies enable a wide range of applications in beam diagnostics, tomography and spectroscopy. The repetition rate of commercially available linear array detectors is a limiting factor for the emerging synchrotron applications. To overcome these limitations, KALYPSO(Karlsruhe Linear arraY detector for MHz rePetition rateSpectrOscopy), an ultra-fast and wide-field of view linear array detector operating at several mega-frames per second(Mfps), has been developed. A silicon micro-strip sensor is connected to custom cutting-edge front end ASICs to achieve unprecedented frame rate in continuous readout mode. In this contribution, the third generation of KALYPSO will be presented