Mineral exploration with ERTS imagery

Ten potential target areas for metallic mineral exploration were selected on the basis of a photo-lineament interpretation of the ERTS image 1172-17141 in central Colorado. An evaluation of bias indicated that prior geologic knowledge of the region had little, if any, effect on target selection. In addition, a contoured plot of the frequency of photo-lineament intersections was made to determine what relationships exist between the photo-lineaments and mineral districts. Comparison of this plot with a plot of the mineral districts indicates that areas with a high frequency of intersections commonly coincide with known mineral districts. The results of this experiment suggest that photo-lineaments are fractures or fracture-controlled features, and their distribution may be a guide to metallic mineral deposits in Colorado, and probably other areas as well

In Vitro Comparative Biocompatibility Testing of Carbofilm Coated and Uncoated Polyetherimide for Cardiovascular Application

When blood contacts the surface of a material, several processes take place including the activation of coagulation and immune systems. The aim of this work is to study in vitro the biological reactions seen from the point of view of hemocompatibility and cytocompatibility of a new polymer suggested as an artificial surface for cardiovascular applications: Carbofilm® coated polyetherimide (C®PEI) in comparison to polyetherimide (PEI), the uncoated form. PEI and C®PEI showed no signs of acute cytotoxicity although following long term incubation with PEI cytotoxicity was somewhat increased; both materials supported good endothelial cell adhesion with a higher level of cell proliferation on the coated form. No significant difference was detected in the activation of the inflammatory response and in thrombogenicity tested by assay of prostaglandin E2 (PGE2) and tromboxane B2 (TXB2) respectively, following incubation of the biomaterials with platelet-rich plasma (PRP). Complement activation assessed by sodium dodecyl sulfate - polyacrylamide gel electrophoresis (SDS-PAGE)/Western Blot analysis of both contacting plasma and protein which adsorbed on the surface of the polymers showed both materials to be activators of complement. In conclusion, Carbofilm® coating, showing lower cytotoxic activity and higher endothelial cell growth in comparison with uncoated material, seems to increase PEI compatibility

The mediation of care and overprotection between parent-adolescent conflicts and adolescents’ psychological difficulties during the pandemic: which role for fathers?

Background: There is evidence of a significant raise in youths’ emotional and behavioral difficulties during the pandemic. Only a few studies have addressed parent-adolescent conflict, and none investigated the possible mediating effect of parenting in the association between conflicts with parents and adolescents’ symptoms. This study aimed at investigating youths’ psychological symptoms during the pandemic, focusing on the predicting effect of parent-adolescent conflict. The mediating role of care and overprotection was also explored, considering whether adolescent gender moderated this mediation. Methods: 195 adolescents aged 14–18 years participated in an online longitudinal study. Perceived conflict with parents and parenting dimensions (Parental Bonding Instrument; PBI) were assessed at baseline (2021). Self-reported psychological difficulties (Strengths and Difficulties Questionnaire; SDQ) were collected at baseline and after one year (2022). Results: A significantly severer symptomatology was found in adolescents having a conflictual relationship with one or both parents. Major conflicts with parents correlated with lower care and greater overprotection in mothers and fathers. However, parental overprotection and maternal care were not mediators of the relationship between conflict and youths' difficulties. The only exception was represented by paternal care that fully mediated this relationship in both adolescent males and females. Conclusions: Although further investigations are needed to overcome limitations due to the small sample, findings extend our insight into the impact of parent-adolescent conflict, highlighting the role of fathers’ care and the need to maximize their involvement in clinical interventions

A portable X-ray fluorescence device for in situ analyses of mural paintings

Within the context of a research program for studying with nondestructive methods the preparation and realisation techniques of mural paintings used in the Roman age, a portable ED-XRF device for elemental analysis has been set up. Preliminary tests have been carried out on two Roman mural paintings belonging to the Baia Archaeological Complex (Naples). Datable to different periods, the two paintings show different manufacturing and conservation states, thus representing a good test for verifying the ED-XRF device capability. In situ and laboratory measurements, performed on materials of different origin and nature, have permitted the determination of the pigments and the recognition of pollution traces

A portable X-ray fluorescence device for in situ analyses of mural paintings

Within the context of a research program for studying with nondestructive methods the preparation and realisation techniques of mural paintings used in the Roman age, a portable ED-XRF device for elemental analysis has been set up. Preliminary tests have been carried out on two Roman mural paintings belonging to the Baia Archaeological Complex (Naples). Datable to different periods, the two paintings show different manufacturing and conservation states, thus representing a good test for verifying the ED-XRF device capability. In situ and laboratory measurements, performed on materials of different origin and nature, have permitted the determination of the pigments and the recognition of pollution traces

Geologic and mineral and water resources investigations in western Colorado using ERTS-1 data

The author has identified the following significant results. Topography was found to be the most important factor defining folds on ERTS-1 imagery of northwestern Colorado; tonal variations caused by rock reflectance and vegetation type and density are the next most important factors. Photo-linears mapped on ERTS-1 imagery of central Colorado correlate well with ground-measured joint and fracture trends. In addition, photo-linears have been successfully used to determine the location and distribution of metallic mineral deposits in the Colorado Mineral Belt. True color composites are best for general geologic analysis and false color composites prepared with positive/negative masks are useful for enhancing local geologic phenomena. During geologic analysis of any given area, ERTS-1 imagery from several different dates should be studied

Integrating comprehensive two-dimensional gas chromatography and downhole fluid analysis to validate a spill-fill sequence of reservoirs with variations of biodegradation, water washing and thermal maturity

Author Posting. © The Author(s), 2016. This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in Fuel 191 (2017): 538-554, doi:10.1016/j.fuel.2016.11.081.Optimization of crude oil production depends heavily on crude oil composition and its variation within individual reservoirs and across multiple reservoirs. In particular, asphaltene content has an enormous impact on crude oil viscosity and even the economic value of the fluids in the reservoir. Thus, it is highly desirable to understand the primary controls on crude oil composition and asphaltene distributions in reservoirs. Here, a complex oilfield in the North Sea containing six separate reservoirs is addressed. The crude oil is believed to have spilled out of deeper reservoirs into shallower reservoirs during the overall reservoir charging process. Asphaltene content is measured in-situ through downhole fluid analysis and is generally consistent with a spill-fill sequence in reservoir charging. Detailed compositional analysis of crude oil samples by comprehensive two-dimensional gas chromatography (GC×GC) is used to determine the extent and variation among the reservoirs of water washing, biodegradation and thermal maturity. Increased biodegradation and water washing in the shallower reservoirs is consistent with a spill-fill sequence. The water washing is evidently assisted by biodegradation. Moreover, analyses of four thermal maturity biomarkers show that shallower reservoirs contain less mature oil, again consistent with a spill-fill sequence. The combination of DFA for bulk compositional analysis and GC×GC for detailed compositional analysis with geochemical interpretation is an effective tool for unraveling complex oilfield scenarios

A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects

Positive allosteric modulators (PAMs) of the μ-opioid receptor (MOR) have been proposed to exhibit therapeutic potential by maximizing the analgesic properties of clinically used opioid drugs while limiting their adverse effects or risk of overdose as a result of using lower drug doses. We herein report in vitro and in vivo characterization of two small molecules from a chemical series of MOR PAMs that exhibit: (i) MOR PAM activity and receptor subtype selectivity in vitro, (ii) a differential potentiation of the antinociceptive effect of oxycodone, morphine, and methadone in mouse models of pain that roughly correlates with in vitro activity, and (iii) a lack of potentiation of adverse effects associated with opioid administration, such as somatic withdrawal, respiratory depression, and analgesic tolerance. This series of MOR PAMs holds promise for the development of adjuncts to opioid therapy to mitigate against overdose and opioid use disorders