4 research outputs found

    One-Pot Multi-Tracer Synthesis of Novel <sup>18</sup>F‑Labeled PET Imaging Agents

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    <sup>18</sup>F labeled phosphonium salts are increasingly important molecular probes for targeting the mitochondrial membrane potential depletion during apoptosis and for detecting myocardial perfusion deficit. Here, we introduce three new tracers, [<sup>18</sup>F]­MitoPhos_04, [<sup>18</sup>F]­MitoPhos_05, and [<sup>18</sup>F]­MitoPhos_07, that have the potential to act as mitochondrial imaging agents. Moreover, they have the added advantage of being synthesized in the same reaction vial from one radiolabeled synthon, demonstrating a new approach to synthesizing multiple tracers in one-pot, which is a highly useful means for increasing the throughput of radiotracer development. The radiosynthesis of the tracers was carried out on a fully automated system via a facile two-step reaction. Utilizing the radiolabeling of an ethyl azide, a copper-mediated 1,3-cycloaddition reaction and isolation via semiprep high-performance liquid chromatography (HPLC) allowed for the simultaneous synthesis of two or three tracers with a total synthesis time of less than 1 h

    Yttrium Phosphasalen Initiators for <i>rac</i>-Lactide Polymerization: Excellent Rates and High Iso-Selectivities

    No full text
    Highly active yttrium phosphasalen initiators for the stereocontrolled ring-opening polymerization of <i>rac</i>-lactide are reported. The initiators are coordinated by a new class of ancillary ligand: an iminophosphorane derivative of the popular “salen” ligand, termed “phosphasalen”. Changing the phosphasalen structure enables access to high iso-selectivities (<i>P</i><sub>i</sub> = 0.84) or hetero-selectivities (<i>P</i><sub>s</sub> = 0.87). The initiators also show very high rates, excellent polymerization control, and tolerance to low loadings; furthermore, no chiral auxiliaries/ligands are needed for the stereocontrol. The combination of such high rates with high iso-selectivities is very unusual

    Yttrium Phosphasalen Initiators for <i>rac</i>-Lactide Polymerization: Excellent Rates and High Iso-Selectivities

    No full text
    Highly active yttrium phosphasalen initiators for the stereocontrolled ring-opening polymerization of <i>rac</i>-lactide are reported. The initiators are coordinated by a new class of ancillary ligand: an iminophosphorane derivative of the popular “salen” ligand, termed “phosphasalen”. Changing the phosphasalen structure enables access to high iso-selectivities (<i>P</i><sub>i</sub> = 0.84) or hetero-selectivities (<i>P</i><sub>s</sub> = 0.87). The initiators also show very high rates, excellent polymerization control, and tolerance to low loadings; furthermore, no chiral auxiliaries/ligands are needed for the stereocontrol. The combination of such high rates with high iso-selectivities is very unusual
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