Genetic draft, selective interference, and population genetics of rapid adaptation

To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare. But if positive selection operates on many loci simultaneously, as has recently been suggested for many species including animals such as flies, a different approach is necessary. In this review, I discuss recent progress in characterizing and understanding evolution in rapidly adapting populations where random associations of mutations with genetic backgrounds of different fitness, i.e., genetic draft, dominate over genetic drift. As a result, neutral genetic diversity depends weakly on population size, but strongly on the rate of adaptation or more generally the variance in fitness. Coalescent processes with multiple mergers, rather than Kingman's coalescent, are appropriate genealogical models for rapidly adapting populations with important implications for population genetic inference.Comment: supplementary illustrations and scripts are available at http://webdav.tuebingen.mpg.de/interference

Factors influencing the nematode community during composting and nematode-based criteria for compost maturity

Pilot studies indicate that shifts in the nematode species composition, life strategies and feeding behavior during composting appear to be fairly consistent and, therefore, promising as a potential tool to assess compost maturity. However, this has been only based on a limited number of, mainly, non-replicated observations. In this study, we tested whether the nematode community succession patterns are recurrent for parallel processes and assessed the relationship between the changes in the nematode community and potential important variables (i.e., temperature, duration of composting and the microbial community). The nematode and microbial community of three simultaneously running Controlled Farm Composting and a reference Green Waste composting process were analyzed through time. Bacterial-feeding enrichment opportunists were most numerous during and directly after the heat peaks. Subsequently, the bacterial-feeding/predator community dominated and the fungal-feeding nematodes became more dominant during maturation, confirming general community patterns from previous experiments. Nematode abundances significantly fluctuated with temperature and the relative abundance of fungal-feeding nematodes increased as the duration of the curing process increased. The amount of fungal-feeding nematodes was associated significantly with both duration of composting and temperature, and the F/(F + B) ratio was only significantly associated with duration of composting. Based on these results, and additional data from an industrial reference compost process and on available literature, a Nematode-based Index of Compost Maturity (NICM) is proposed, combining four nematode-based criteria (i.e., nematode abundance, F/(F + B) ratio, the presence of more than one fungal-feeding taxon and the presence of diplogasterids). Nevertheless, the NICM should be considered as work in progress which should be tested for a wider range of composts from diverse feedstock mixtures, locations (sites) and composting techniques, to validate the use of the index and allow more reliable interpretation of particular values of this index

Vibrating Vane, Absolute Gas Pressure Gauge

An oscillating rectangular vane suspended by a fine quartz fiber is used to determine the absolute pressure of the gas in which it is located. Aside from being an absolute instrument, the advantages of such a device are (1) simplicity, (2) the fact that it does not change the pressure when an observation is made as do many other types of gauges, and (3) the absence of a heated filament which may decompose the gas under study

Millikan-Teacher and Friend

As a result of support by Addison-Wesley Publishing Company, the American Association of Physics Teachers has established an annual lectureship, named in honor of Robert A. Millikan. It is anticipated that this will bring to each summer meeting of the Association a physicist who will speak on a topic of current interest and that the summer meeting will thus have a feature comparable with the Richtmyer Lecture at the annual meeting. The committee responsible for the first Millikan Lecture chose H. V. Neher, long time associate of Millikan. This highly suitable choice was as appropriate as was Neher's choice of a topic- Millikan himself. The editors of the American Journal of Physics are grateful for permission to publish this pleasantly informal biographical lecture, spiced as it is with personal reminiscences

Preferences for redistribution around the world

Gender, income, education and self-employment are robust predictors for individual support for redistribution in the OECD. In addition, considerations of social status, the fairness of the allocation mechanism, perceived moral worth of the poor and individual autonomy are important. The results for the OECD are compared to those for a large sample of non-OECD countries which also include less developed economies. Neither gender, nor self-employment, nor fairness considerations exhibit a robust association with preferences for redistribution. However, education, income, individual autonomy and moral worth of the poor remain important determinants. On average, preferences for redistribution indicate that within the OECD, there is no desire to change redistributive policies. In contrast, in the sample of non-OECD countries, on average there is a desire to redistribute less. --preferences for redistribution,social rivalry effect,social identity,survey data,World Values Survey

Income Inequality and Self-Reported Values

This paper offers a comprehensive econometric investigation of the impact of income inequality on the values endorsed by people. Using survey data from all thirty-four OECD countries over a period of almost thirty years, the following dimensions of value systems are investigated: work ethic, civism, obedience, honesty, altruism, and tolerance. In most cases, no robust effects from inequality on values are detected. However, there is evidence that a more unequal income distribution strengthens the work ethic of the population. Thus, income inequality seems to generate work incentives not only via the pecuniary reward of work but also through the symbolic reward it receives

Metal System for Chemical Reactions and for Studying Properties of Gases and Liquids

An all-metal system, made of copper, is herein described. It is suitable for working with those chemicals which do not attack copper. In particular it has been found very useful in the purification of BF3 and B(CH3)3. Some important features of such a system are (1) a complete absence of contaminants; (2) reactions may be carried out up to 500°C; (3) pressures up to several hundred pounds per square inch may be used; (4) flow of gases from very low to very high pressures may be easily controlled; (5) the system is very rugged. This latter point is particularly desirable where noxious or inflammable gases (such as B(CH3)3) are used. A method is also described whereby gases from sealed-off containers under either high or low pressures may be easily retrieved without introducing impurities. Other important advantages of such a system are mentioned in the text

Competition between recombination and epistasis can cause a transition from allele to genotype selection

Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference of epistasis from the observed phenotype-genotype correlation is impeded by statistical difficulties, while the theoretical understanding of the effects of epistasis remains limited, in turn limiting our ability to interpret data. Of particular interest is the biologically relevant situation of numerous interacting genetic loci with small individual contributions to fitness. Here, we present a computational model of selection dynamics involving many epistatic loci in a recombining population. We demonstrate that a large number of polymorphic interacting loci can, despite frequent recombination, exhibit cooperative behavior that locks alleles into favorable genotypes leading to a population consisting of a set of competing clones. When the recombination rate exceeds a certain critical value that depends on the strength of epistasis, this "genotype selection" regime disappears in an abrupt transition, giving way to "allele selection"-the regime where different loci are only weakly correlated as expected in sexually reproducing populations. We show that large populations attain highest fitness at a recombination rate just below critical. Clustering of interacting sets of genes on a chromosome leads to the emergence of an intermediate regime, where blocks of cooperating alleles lock into genetic modules. These haplotype blocks disappear in a second transition to pure allele selection. Our results demonstrate that the collective effect of many weak epistatic interactions can have dramatic effects on the population structure.Comment: Supplementary Material available on PNAS websit