う歯および歯周病とメタボリックシンドロームのコンポーネントとの関連 : 労働者の1年間の追跡調査から

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 佐々木 敏, 東京大学特任准教授 脇 嘉代, 東京大学教授 松山 裕, 東京大学講師 小笠原 徹, 東京大学講師 末永 英之University of Tokyo(東京大学

Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers

<p>Abstract</p> <p>Background</p> <p>We reported that the compositions of arachidonic acid (ARA) in erythrocytes and plasma phospholipids (PL) in the elderly were lower than those in the young, though the ARA intake was nearly identical.</p> <p>Objective</p> <p>We further analyzed data in four study groups with different ages and sexes, and determined that the blood ARA levels were affected by the kinds of dietary fatty acids ingested.</p> <p>Methods</p> <p>One hundred and four healthy young and elderly volunteers were recruited. Dietary records together with photographic records from 28 consecutive days were reviewed and the fatty acid composition in plasma lipid fractions and erythrocyte PL was analyzed.</p> <p>Results</p> <p>No correlations for ARA between dietary fatty acids and blood lipid fractions were observed. A significant negative correlation between eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) intake and ARA composition in erythrocyte PL was observed. ARA composition in erythrocyte PL was significantly lower in elderly subjects than in young subjects, because EPA and DHA intake in elderly subjects was higher than in young subjects. However, after removing the effect of dietary EPA+DHA intake, the ARA composition in erythrocyte PL in elderly subjects was significantly lower than that in young subjects.</p> <p>Conclusions</p> <p>Changes in physical conditions with aging influenced the low ARA composition of erythrocyte in elderly subjects in addition to the effects of dietary EPA and DHA.</p

The safety for drinking of hot spring hydrogen water

The safety for drinking of hot spring hydrogen water was examined for 27 healthy women. The research method was the crossover comparison examination of hot spring hydrogen water and tap water for four weeks. The blood cell count, liver function, kidney function, plasma lipids, and electrolytes were measured before and after drinking. Mean corpuscular volume and mean corpuscular hemoglobin concentration significantly decreased after drinking of hot spring hydrogen water and tap water. The plasma total protein, blood urea nitrogen, and total cholesterol significantly decreased after drinking the hot spring hydrogen water. Other data showed no significant changes. These results suggested that the drinking of hot spring hydrogen water was almost safe