Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release

© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)This study was funded by the British Heart Foundation (RG/09/002/2642 to F.M.M.-B.) and the Medical Research Council of the UK (G0901084 to F.M.M.-B.). ImageStream X was funded by the Wellcome Trust (101604/Z/13/Z). This work forms part of the research themes contributing to the translational research portfolio of Barts and the London Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institute of Health Research

A simple method of estimating folic acid absorption (a modified faecal excretion method)

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On the screening of static electromagnetic fields in hot QED plasmas

We study the screening of static magnetic and electric fields in massless quantum electrodynamics (QED) and massless scalar electrodynamics (SQED) at temperature $T$. Various exact relations for the static polarisation tensor are first reviewed and then verified perturbatively to fifth order (in the coupling) in QED and fourth order in SQED, using different resummation techniques. The magnetic and electric screening masses squared, as defined through the pole of the static propagators, are also calculated to fifth order in QED and fourth order in SQED, and their gauge-independence and renormalisation-group invariance is checked. Finally, we provide arguments for the vanishing of the magnetic mass to all orders in perturbation theory.Comment: 37 pages, 8 figure

The Finite Temperature SU(2) Savvidy Model with a Non-trivial Polyakov Loop

We calculate the complete one-loop effective potential for SU(2) gauge bosons at temperature T as a function of two variables: phi, the angle associated with a non-trivial Polyakov loop, and H, a constant background chromomagnetic field. Using techniques broadly applicable to finite temperature field theories, we develop both low and high temperature expansions. At low temperatures, the real part of the effective potential V_R indicates a rich phase structure, with a discontinuous alternation between confined (phi=pi) and deconfined phases (phi=0). The background field H moves slowly upward from its zero-temperature value as T increases, in such a way that sqrt(gH)/(pi T) is approximately an integer. Beyond a certain temperature on the order of sqrt(gH), the deconfined phase is always preferred. At high temperatures, where asymptotic freedom applies, the deconfined phase phi=0 is always preferred, and sqrt(gH) is of order g^2(T)T. The imaginary part of the effective potential is non-zero at the global minimum of V_R for all temperatures. A non-perturbative magnetic screening mass of the form M_m = cg^2(T)T with a sufficiently large coefficient c removes this instability at high temperature, leading to a stable high-temperature phase with phi=0 and H=0, characteristic of a weakly-interacting gas of gauge particles. The value of M_m obtained is comparable with lattice estimates.Comment: 28 pages, 5 eps figures; RevTeX 3 with graphic

Emotions and Digital Well-being. The rationalistic bias of social media design in online deliberations

In this chapter we argue that emotions are mediated in an incomplete way in online social media because of the heavy reliance on textual messages which fosters a rationalistic bias and an inclination towards less nuanced emotional expressions. This incompleteness can happen either by obscuring emotions, showing less than the original intensity, misinterpreting emotions, or eliciting emotions without feedback and context. Online interactions and deliberations tend to contribute rather than overcome stalemates and informational bubbles, partially due to prevalence of anti-social emotions. It is tempting to see emotions as being the cause of the problem of online verbal aggression and bullying. However, we argue that social media are actually designed in a predominantly rationalistic way, because of the reliance on text-based communication, thereby filtering out social emotions and leaving space for easily expressed antisocial emotions. Based on research on emotions that sees these as key ingredients to moral interaction and deliberation, as well as on research on text-based versus non-verbal communication, we propose a richer understanding of emotions, requiring different designs of online deliberation platforms. We propose that such designs should move from text-centred designs and should find ways to incorporate the complete expression of the full range of human emotions so that these can play a constructive role in online deliberations

Spectral function of spinless fermions on a one-dimensional lattice

We study the spectral function of interacting one-dimensional fermions for an integrable lattice model away from half-filling. The divergent power-law singularity of the spectral function near the single-particle or single-hole energy is described by an effective x-ray edge type model. At low densities and for momentum near the zone boundary, we find a second divergent singularity at higher energies which is associated with a two-particle bound state. We use the Bethe ansatz solution of the model to calculate the exact singularity exponents for any momentum and for arbitrary values of chemical potential and interaction strength in the critical regime. We relate the singularities of the spectral function to the long-time decay of the fermion Green's function and compare our predictions with numerical results from the time-dependent density matrix renormalization group (tDMRG). Our results show that the tDMRG method is able to provide accurate time decay exponents in the cases of power-law decay of the Green's function. Some implications for the line shape of the dynamical structure factor away from half-filling are also discussed. In addition, the spectral weight of the Luttinger liquid result for the dynamical structure factor of the Heisenberg model at zero field is compared with the exact two-spinon contribution.Comment: 30 pages, 18 figure

Quark-Gluon Plasma as a Condensate of Z(3) Wilson Lines

Effective theories for the thermal Wilson line are constructed in an SU(N) gauge theory at nonzero temperature. I propose that the order of the deconfining phase transition for Z(N) Wilson lines is governed by the behavior of SU(N) Wilson lines. In a mean field theory, the free energy in the deconfined phase is controlled by the condensate for Z(N) Wilson lines. Numerical simulations on the lattice, and the mean field theory for Z(3) Wilson lines, suggest that about any finite temperature transition in QCD, the dominant correlation length increases by a large, uniform factor, of order five.Comment: 5 pages, LaTe

Connection between Chiral Symmetry Restoration and Deconfinement

We propose a simple explanation for the connection between chiral symmetry restoration and deconfinement in QCD at high temperature. In the Higgs description of the QCD vacuum both spontaneous chiral symmetry breaking and effective gluon masses are generated by the condensate of a color octet quark-antiquark pair. The transition to the high temperature state proceeds by the melting of this condensate. Quarks and gluons become (approximately) massless at the same critical temperature. For instanton-dominated effective multiquark interactions and three light quarks with equal mass we find a first order phase transition at a critical temperature around 170 MeV.Comment: New section on vortices,33 pages,LaTe

Two flavor chiral phase transition from nonperturbative flow equations

We employ nonperturbative flow equations to compute the equation of state for two flavor QCD within an effective quark meson model. This yields the temperature and quark mass dependence of quantities like the chiral condensate or the pion mass. A precision estimate of the universal critical equation of state for the three-dimensional O(4) Heisenberg model is presented. We explicitly connect the O(4) universal behavior near the critical temperature and zero quark mass with the physics at zero temperature and a realistic pion mass. For realistic quark masses the pion correlation length near T_c turns out to be smaller than its zero temperature value.Comment: 49 pages including 15 figures, LaTeX, uses epsf.sty and rotate.st

News from Lattice QCD on Heavy Quark Potentials and Spectral Functions of Heavy Quark States

We discuss recent lattice results on in-medium properties of hadrons and focus on thermal properties of heavy quark bound states. We will clarify the relation between heavy quark free energies and potentials used to analyze the melting of heavy quark bound states. Furthermore, we present calculations of meson spectral functions which indicate that the charmonium ground states, J/psi and eta_c, persist in the quark gluon plasma as well defined resonances with no significant change of their zero temperature masses at least up to T ~ 1.5 T_c. We also briefly comment on the current status of lattice calculations at non-vanishing baryon number density.Comment: Plenary talk at the 17th International Conference on Ultra Relativistic Nucleus-Nucleus Collisions (Quark Matter 2004), Oakland, California, 11-17 Jan 2004. Submitted to J.Phys.