The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders

Recent evidence suggests that the GABA transporter 1 (GAT-1; SLC6A1) plays a role in the pathophysiology and treatment of anxiety disorders. In order to understand the impact of genetic variation within SLC6A1 on pathological anxiety, we performed a case–control association study with anxiety disorder patients with and without syndromal panic attacks. Using the method of sequential addition of cases, we found that polymorphisms in the 5′ flanking region of SLC6A1 are highly associated with anxiety disorders when considering the severity of syndromal panic attacks as phenotype covariate. Analysing the effect size of the association, we observed a constant increase in the odds ratio for disease susceptibility with an increase in panic severity (OR ~ 2.5 in severely affected patients). Nominally significant association effects were observed considering the entire patient sample. These data indicate a high load of genetic variance within SLC6A1 on pathological anxiety and highlight GAT-1 as a promising target for treatment of anxiety disorders with panic symptoms

The relationship between manual coordination and mental health

Motor coordination impairments frequently co-occur with other developmental disorders and mental health problems in clinically referred populations. But does this reflect a broader dimensional relationship within the general population? A clearer understanding of this relationship might inform improvements in mental health service provision. However, ascertainment and referral bias means that there is limited value in conducting further research with clinically referred samples. We, therefore, conducted a cross-sectional population-based study investigating children’s manual coordination using an objective computerised test. These measures were related to teacher-completed responses on a behavioural screening questionnaire [the Strength and Difficulties Questionnaire (SDQ)]. We sampled 298 children (4–11 years old; 136 males) recruited from the general population. Hierarchical (logistic and linear) regression modelling indicated significant categorical and continuous relationships between manual coordination and overall SDQ score (a dimensional measure of psychopathology). Even after controlling for gender and age, manual coordination explained 15 % of the variance in total SDQ score. This dropped to 9 % after exclusion of participants whose SDQ responses indicated potential mental health problems. These results: (1) indicate that there is a clear relationship between children’s motor and mental health development in community-based samples; (2) demonstrate the relationship’s dimensional nature; and (3) have implications for service provision

Using the FRIENDS Programs to Promote Resilience in Cross-Cultural Populations

Childhood and adolescence is a time of rapid biological, psychological, and social growth. Prevalence rates around the world currently estimate approximately one in five adolescents experience mental health difficulties. As factors are increasingly implicated in the etiology of behavioral and emotional difficulties, clinicians and researchers have identified the need for resilience-enhancing prevention programs. The current authors redefine resilience as not only being able to navigate towards and negotiate for resources in the face of adversity, but also to embrace positive life challenges. This chapter discusses protective and risk factors of emotional well-being in youths to provide a framework for the development of resilience-building programs. A brief review of resilience enhancement in youths is provided as well as introduction to the FRIENDS protocol, four socio-emotional skills programs. The FRIENDS programs are robustly supported and the only program endorsed by the World Health Organization for the prevention and treatment of anxiety and depression in children and youth (Prevention of mental disorders: Effective interventions and policy options, Geneva, Switzerland, 2004). Description of the FRIENDS programs, research evaluating intervention outcomes, and strategies to adapt techniques for use in diverse youth populations are also included. Lastly, recent innovations in conceptualization, research, assessment, and treatment of resilience as well as future directions for research are discussed