1,192 research outputs found
Reduced-Order Modelling of the Bending of an Array of Torsional Micromirrors
Reduced-Order Modelling of the Bending of an Array of An array of
micromirrors for beam steering optical switching has been designed in a thick
polysilicon technology. A novel semi-analytical method to calculate the static
characteristics of the micromirrors by taking into account the flexural
deformation of the structure is presented. The results are compared with 3D
coupled-field FEM simulation.Comment: Submitted on behalf of TIMA Editions
(http://irevues.inist.fr/tima-editions
Non-Symmetrized Hyperspherical Harmonics Method for Non-Equal Mass Three-Body Systems
The non-symmetrized hyperspherical harmonics method for a three-body system,
composed by two particles having equal masses, but different from the mass of
the third particle, is reviewed and applied to the H, He nuclei and
H hyper-nucleus, seen respectively as , and
three-body systems. The convergence of the method is first tested
in order to estimate its accuracy. Then, the difference of binding energy
between H and He due to the difference of the proton and the neutron
masses is studied using several central spin-independent and spin-dependent
potentials. Finally, the H hypernucleus binding energy is
calculated using different and potential models. The results
have been compared with those present in the literature, finding a very nice
agreement.Comment: 15 pages, 1 figure and 14 tables, version revisited according to
referees suggestion
Letter to the editor concerning “Liver transplantation for metastatic wild-type gastrointestinal stromal tumor in the era of molecular targeted therapies: Report of a first case"
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Which affects affect the use of new technologies? Italian adaptation of the Internet Motive Questionnaire for Adolescents (IMQ-A) and criterion validity with problematic use and body dissatisfaction
Given the negative role of problematic use of new technological devices (NTD) in behavioral and psychological domains, the aim of the study is the Italian adaptation and validation of the Internet Motive Questionnaire for Adolescents (IMQ-A) in order to understand the motivation for the use of NTD. A total of 769 students 10-19 aged (M = 13.22, SD = 1.56) completed the IMQ-A, the Collins Figures Rating Scale, and two measures regarding the problematic NTD use, focused on overuse during the night and during meals. The IMQ-A showed adequate internal consistency with regard to its four subscales: Coping (α = .84), Social (α = .80), Enhancement (α = .80), and Conformity (α = .68) motives. However, with regard to factorial structure, a threefactor model (excluding Conformity subscale) showed slightly better fit indices than the original model. Coping motive was correlated with problematic NTD use and succeeded in predicting higher scores in body dissatisfaction as evidence of criterion-related and external validity. The Italian adaptation of the IMQ-A can be useful in both research and clinical fields, in order to propose alternative strategies for coping to users and to improve emotion regulation facets
Design for six sigma (DFSS) applied to a new eco-motorbike
The primary purpose of this work is to organize, in the best possible way, the design of an ecological transport vehicle, using an advanced design methodology, namely design for six sigma (DFSS). The DFSS is indeed a design approach, able to implement, in a logical and integrated way, other advanced methodologies of systematic design, such as quality function deployment (QFD), TRIZ (in Russian, Teorija Resenija Izobretatel'skich Zadac), benchmarking, top-flop analysis and others, in order to propose design solutions oriented both to quality and innovation, for satisfying customers. The above described has been demonstrated through the application of DFSS to a case study in which the set up phase of an industrial project was completed, without having overlooked any aspect useful for obtaining a new attractive product. The case study concerns the application of DFSS to a new low-polluting motorcycle. At the end of the work, the designer obtained the achievement of the conceptual project
Thermal Noise-Boosting Effects in Hot-Wire-Based Micro Sensors
This article proposes an original approach aimed at modelling the noise density in sensors based on a single hot wire or pairs of thermally coupled wires. The model consists in an original combination of a previous electrothermal model of the wire with well-established assumptions on the thermal noise in conductors that carry moderate current densities. A simple method for estimating the model parameters with simple impedance spectroscopy is suggested. The predicted power spectral densities of the wire thermal noise differ from the result of previously presented analytical models, stimulating further experimental studies. The effects of the electrothermal feedback of both hot wires and hot-wire pairs on flicker noise is also intrinsically covered by the proposed approach
SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
Loss of function of the succinate dehydrogenase complex characterizes 20-40% of all KIT/PDGFRA-negative GIST. Approximately half of SDH-deficient GIST patients lack SDHx mutations and are caused by a hypermethylation of the SDHC promoter, which causes the repression of SDHC transcription and depletion of SDHC protein levels through a mechanism described as epimutation. The remaining 50% of SDH-deficient GISTs have mutations in one of the SDH subunits and SDHA mutations are the most common (30%), with consequent loss of SDHA and SDHB protein expression immunohistochemically. SDHB, SDHC, and SDHD mutations in GIST occur in only 20-30% of cases and most of these SDH mutations are germline. More recently, germline mutations in SDHA have also been described in several patients with loss of function of the SDH complex. SDHA-mutant patients usually carry two mutational events at the SDHA locus, either the loss of the wild type allele or a second somatic event in compound heterozygosis. This review provides an overview of all data in the literature regarding SDHA-mutated GIST, especially focusing on the prevalence of germline mutations in SDH-deficient GIST populations who harbor SDHA somatic mutations, and offers a view towards understanding the importance of genetic counselling for SDHA-variant carriers and relatives
Preclinical Models of Visceral Sarcomas
Visceral sarcomas are a rare malignant subgroup of soft tissue sarcomas (STSs). STSs, accounting for 1% of all adult tumors, are derived from mesenchymal tissues and exhibit a wide heterogeneity. Their rarity and the high number of histotypes hinder the understanding of tumor development mechanisms and negatively influence clinical outcomes and treatment approaches. Although some STSs (~20%) have identifiable genetic markers, as specific mutations or translocations, most are characterized by complex genomic profiles. Thus, identification of new therapeutic targets and development of personalized therapies are urgent clinical needs. Although cell lines are useful for preclinical investigations, more reliable preclinical models are required to develop and test new potential therapies. Here, we provide an overview of the available in vitro and in vivo models of visceral sarcomas, whose gene signatures are still not well characterized, to highlight current challenges and provide insights for future studies
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