Russian version of CU-Q2oL questionnaire for estimation of quality of life of patients with chronic urticaria

The research objective is to work out the creation of Russian-language questionnaire for assessing quality of life of patients with chronic urticaria by adapting the questionnaire «Chronic Urticaria Quality of Life Questionnaire» (CU-Q2oL) to Russian conditions. The study involved 150 patients aged 18 to 50 years (32,41±6,02) with chronic urticaria. Cultural and linguistic adaptation of the questionnaire was conducted according to international methodology. Evaluation of reliability was conducted by calculating Cronbach's б-coefficient, constructive validity -the method of «known groups» and the identification of mutual correlations with the scales of the SF-36 questionnaire, sensitivity-by comparing the quality of life before and after the treatment. High values of Cronbach's б-coefficient (>0.72) were obtained, the dependence of quality of life on the severity of chronic urticaria was proved to be significant, as well as the sensitivity of the questionnaire to clinical changes. The research findings confirmed good psychometric properties of Russian version of the questionnaire. The developed version of the questionnaire is a reliable, valid and sensitive device for assessing the quality of life in patients with chronic urticaria, and may be used in scientific and clinical research

MODERN ASPECTS OF ALLERGIC RHINITIS PHARMACOEPIDEMIOLOGY IN CHILDREN

The article provides the authors’ proprietary data on the epidemiology of allergic rhinitis, as well as the results of assessing the adequacy of existing approaches to diagnostics, monitoring and treatment of children in Volgograd. A retrospective descriptive research was conducted using the data of 330 outpatient medical records of children aged 1 to 16 years diagnosed with allergic rhinitis. Analysis was made of the age at which the disease was verified, the diagnosis formulation, family medical history, related allergic diseases, therapeutic and diagnostic tactics. It was found that an average of 5,5 years elapse from the time the symptoms are identified to the time a diagnosis is made. 21% of children have first symptoms of the disease already at an early age (prior to 3 years). 71% of children had it in combination with other allergic diseases. Second-generation antihistamines are now increasingly used for treatment of allergic rhinitis, while intranasal corticosteroids are still not used frequently enough.Key words: pharmacoepidemiology, epidemiology, allergic rhinitis, bronchial asthma, children

THE METHOD OF MEASURING AIRWAY RESISTANCE IN PRESCHOOL CHILDREN, BASED ON THE TECHNIQUE BRIEFLY INTERRUPTING THE FLOW: BRONCHODILATORS TEST’S PRACTICE

Objective: To evaluate the prospects of a new noninvasive technique for measuring airflow obstruction in pediatrics. Materials and methods: The spirograph SuperSpiro with module MicroRint. Indicators of airflow obstruction (FEV1, PEF) and airway resistance (Rint) before and after inhalation of 200 micrograms salbutamol (test with bronchodilator) were measured in 36 children of 5–6 years old with asthma. Calculated the growth/fall in the second attempt on the outcome of each method, then the data series for each method were compared with each other. Results: FEV growth averaged 14,5%, an increase of PEF — 17,5% by the end. Fall Rint index averaged 0,25 kPa/l/s. Under positive-sum test according to the ERF (30 patients out of 36) Rint drop occurred in all cases, and an average of 0,28 kPa/l/s with. Correlation (Rint and FEV r = -0,93, Rint and PEF r = -0,96) between the indices is very high. Conclusion: The technique Rint is an alternative to the classical spirometry in young children.Key words: children, allergic diseases, bronchial asthma, airway resistance, test with bronchodilator

MEASURING OF AIRWAYS RESISTANCE BASED ON INTERRUPTER TECHNIQUE IN PRE-SCHOOLCHILDREN

Authors give information on limits of population norm for expiratory and inspiratory resistance by the interrupter technique indices (RINTexp and RINTinsp accordingly) in 214 healthy children 3–6 years old. Estimation of RINT was performed with spirograph Super Spiro with MicroRint module. Parameters of RINTexp and RINTinsp are similar in boys and girls. RINTexp depends on height of a child. Information on limits of normal rates is presented in this article, and this data can be used in diagnostics of respiratory pathology. Key words: children, age, resistance of airways, RINT, norm.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(5):30-34

СОВРЕМЕННЫЕ АСПЕКТЫ ФАРМАКОЭПИДЕМИОЛОГИИ АЛЛЕРГИЧЕСКОГО РИНИТА У ДЕТЕЙ

The article provides the authors’ proprietary data on the epidemiology of allergic rhinitis, as well as the results of assessing the adequacy of existing approaches to diagnostics, monitoring and treatment of children in Volgograd. A retrospective descriptive research was conducted using the data of 330 outpatient medical records of children aged 1 to 16 years diagnosed with allergic rhinitis. Analysis was made of the age at which the disease was verified, the diagnosis formulation, family medical history, related allergic diseases, therapeutic and diagnostic tactics. It was found that an average of 5,5 years elapse from the time the symptoms are identified to the time a diagnosis is made. 21% of children have first symptoms of the disease already at an early age (prior to 3 years). 71% of children had it in combination with other allergic diseases. Second-generation antihistamines are now increasingly used for treatment of allergic rhinitis, while intranasal corticosteroids are still not used frequently enough.Key words: pharmacoepidemiology, epidemiology, allergic rhinitis, bronchial asthma, children.В статье подробно рассмотрены вопросы эпидемиологии и фармакоэпидемиологии аллергического ринита у детей г. Волгограда. Результаты проведенного исследования выявили: существующие подходы к диагностике и лечению аллергического ринита у детей не соответствуют международным и национальным рекомендациям. Терапия назначается эмпирическим путем, направлена на быстрое снятие клинических симптомов, а не на долговременный контроль аллергического воспаления. Ключевые слова: фармакоэпидемиология, эпидемиология, аллергический ринит, бронхиальная астма, дети. (Педиатрическая фармакология. – 2009;6(6): 60-65

МЕТОД ИЗМЕРЕНИЯ СОПРОТИВЛЕНИЯ ДЫХАТЕЛЬНЫХ ПУТЕЙ У ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА, ОСНОВАННЫЙ НА ТЕХНИКЕ КРАТКОВРЕМЕННОГО ПРЕРЫВАНИЯ ПОТОКА: ПРИМЕНЕНИЕ ПРОБ С БРОНХОЛИТИКАМИ

Objective: To evaluate the prospects of a new noninvasive technique for measuring airflow obstruction in pediatrics. Materials and methods: The spirograph SuperSpiro with module MicroRint. Indicators of airflow obstruction (FEV1, PEF) and airway resistance (Rint) before and after inhalation of 200 micrograms salbutamol (test with bronchodilator) were measured in 36 children of 5–6 years old with asthma. Calculated the growth/fall in the second attempt on the outcome of each method, then the data series for each method were compared with each other. Results: FEV growth averaged 14,5%, an increase of PEF — 17,5% by the end. Fall Rint index averaged 0,25 kPa/l/s. Under positive-sum test according to the ERF (30 patients out of 36) Rint drop occurred in all cases, and an average of 0,28 kPa/l/s with. Correlation (Rint and FEV r = -0,93, Rint and PEF r = -0,96) between the indices is very high. Conclusion: The technique Rint is an alternative to the classical spirometry in young children.Key words: children, allergic diseases, bronchial asthma, airway resistance, test with bronchodilator.Цель: оценить перспективы применения новой неинвазивной методики измерения функции внешнего дыхания (ФВД) в педиатрии. Пациенты и методы: использовался спирограф SuperSpiro с модулем MicroRint. У 36 детей в возрасте 5–7 лет, страдающих бронхиальной астмой, проводились измерения показателей ФВД — объема форсированного выдоха (ОФВ1), пиковой скорости выдоха (ПСВ) и сопротивления дыхательных путей (Rint) до и после ингаляции 200 мкг сальбутамола (проба с бронхолитиком). Вычислялся прирост/падение показателей второй попытки относительно исхода каждого метода, затем ряды данных для каждой методики сравнивались между собой. Результаты: прирост ОФВ1 в среднем составил 14,5%, прирост ПСВ — 17,5% к исходным значениям. Падение индекса Rint составило в среднем 0,25 кПа/л/с. В группе с положительным исходом пробы по данным ФВД (30 больных из 36) падение Rint имело место во всех случаях и составило в среднем 0,28 кПа/л/с. Выявлена корреляция между показателями: Rint и ОФВ1, r= -0,93; Rint и ПСВ, r= -0,96. Вывод: методика Rint для детей дошкольного возраста является альтернативой классической спирометрии. Ключевые слова: дети, аллергические болезни, бронхиальная астма, сопротивление дыхательных путей, проба с бронхолитиком. (Педиатрическая фармакология -2011; 8(3):38-46