PECULIARITIES OF CLINIC AND COURSE OF VIBRATION DISEASE IN THE VIBRATION EXPOSURED MINERS OF KUZBASS REGION

Clinical manifestations of vibration pathology with different degree of pathological process intensity were studied in 288 vibration exposured miners. Peculiarities of formation of vibration pathology in Kuzbass miners are connected with the development of angiodystonic syndrome (97—100 %) with acrospasm attacks. Formation. of vibration pathology is associated with the increase of arterial hypertension incidence — up to 28,3 % at stage I and up to 34,1 % at stage II, that is possibly caused by the increase of endothelia system dysfunction. There is progressive disease course both in the persons continuing contact with vibration and in those who stopped it

METHOD FOR THE PREDICTION OF THE DEVELOPMENT OF CHRONIC PULMONARY HEART IN COAL WORKERS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

452 miners at the age of40-55years (average age is 50,9 ± 0,2 years) with chronic obstructive pulmonary disease were studied. Chronic pulmonary heart was detected in 289 patients (63,9 %). Using Bayes' method based on the determination of prognostic factors we have elaborated the technique for the prediction of the development of chronic pulmonary heart in miners with chronic obstructive pulmonary disease. The technique is based on the presence of respiratory insufficiency, associated ischemic heart disease and arterial hypertension, blood groups by AB0, MN, and P systems, some structural and functional indicators of heart (a myocardium mass index of aortic ventricle heart, an index of relative thickness of walls of aortic ventricle heart, an index of sphericity of aortic ventricle heart and an average pressure in a pulmonary artery). The use of genetic markers of blood groups by AB0, MN, and P systems allows more detailed estimate genetic predisposition to disease. By increasing the number of analyzed factors influencing the development of chronic pulmonary heart and using of additional markers, we have more accurate prediction of this complication. All figures are reduced in the general prognostic table. The work with the table is the following, it is necessary to sum up all the prognostic coefficients taking into account a sign. At the value of total amount of+6 points or more predisposition to development of chronic pulmonary heart for a worker is more predicted, at the sum less than -6 points we predict the resistance to development of chronic pulmonary heart, at intermediate values the forecast is not defined. The main advantage of the technique is speed and minor material costs. So, while conducting a single assessment of the health of miners with chronic obstructive pulmonary disease in outpatient and polyclinic conditions it is simply to select a group of persons at high risk of developing chronic pulmonary heart for timely preventive actions

POLYMORPHISM OF GSTM1 AND GSTT1 GENES IN WORKERS OF FERROUS METALLURGY WITH PROFESSIONAL FLUOROSIS

The aim of the present work was to study genetic risk factors for the development of professional fluorosis in workers of Novokuznetsk aluminum factory, the presence of which is associated with the risk of professional dental fluorosis and resistance to it. The study involved 79 male workers of Novokuznetsk aluminum factory Ltd. "RUSAL" of 35-60 years. The control group (212 people) consisted of healthy individuals working for the same company and without fluorosis. The material for the study were the venous blood samples. Polymorphism of null-alleles of genes encoding transferase phase 2 biotransformation of xenobiotics - GSTT1 and GSTM1 was studied. In this study DNA was isolated by phenolhloroformnym method performing polymerase chain reaction amplification products electrophoresed on agarose gel, and the products were visualized under ultraviolet light. The frequencies of alleles and genotypes in groups of patients and healthy subjects were compared using the χ2 test with Yates correction for continuity. The association of different genotypes (or combinations thereof) was estimated by the magnitude of the disease odds ratio (OR). The frequencies of alleles and phenotypes in our sample were studied on an aluminum factory workers and were already comparable to previously published data on Russian Federation and Siberian federal district. Analysis of differences in genotype frequencies between patients with fluorosis and those of the control group using χ2 criteria and OR shows that the largest contribution to the risk of developing the disease is making by null-allele of the GSTT1 gene (GSTT1(-)), as well as the "double zero" - a combination of GSTT1(-) and GSTM1(-). On the other hand the holders GSTT1(+)) as well as combinations of genotypes GSTT1(+) / GSTM1(-) are the most resistant to this disease genotype. The obtained data can be used in the formation of risk groups for development of fluorosis, for timely diagnosis and prevention of loss of workers' health

THE INFLUENCE OF CONCOMITANT CARDIOVASCULAR PATHOLOGY (ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION) ON THE CHANGES OF RIGHT VENTRICLE OF HEART IN MINERS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Associated cardiovascular pathology (ischemic heart disease and arterial hypertension.) in miners with chronic obstructive pulmonary disease increases the degree of hypertrophy of myocardium of right ventricle of heart and worsens its systolic and diastolic functions

DISTRIBUTION OF BIOCHEMICAL AND MOLECULAR-GENETIC MARKERS OF GENES IN WORKERS OF COAL MINING ENTERPRISES OF KUZBASS REGION SUFFERING FROM CHRONIC DUST BRONCHITIS

Distribution of genotypes of biochemical markers of HP, GC, EsD, АсР genes, genotypes on polymorphic variants of the genes coding enzymes of biotransformation GSTT1 (GST-ɵ1) and GSTM1 (GST-μ1) and NOS3 (VNTR4 polymorphism) in the miners with chronic mechanic bronchitis, and in persons without this occupational pathology is investigated. It is shown that the owners of EsD 1-2, АсР bb genotypes are most subject to development of chronic mechanic bronchitis. Endogen factors of resistance to this disease are GC 1-1, EsD 1-1, АсР bc genotypes

Experimental complex for research of vibration protection combined system of transportation and technological machines operator

The article is devoted to the structure and description development of the technical solutions which used in the stand design for studying the dynamics of the transport and technological machines operator vibration protection combined system which used in building. As a load-bearing elements of passive and active vibration protection systems are encouraged to use rubber-cord casing. Stand structure should allow to evaluate the contribution of both passive and active vibration protection system in the general process of oscillations suppression

Multipurpose resource inventory in Far East - Economical aspects

Mimeograp

Multipurpose resource inventory in Far East (Economical aspect)

Session 1