510 research outputs found
Low-lying excitations and magnetization process of coupled tetrahedral systems
We investigate low-lying singlet and triplet excitations and the
magnetization process of quasi-1D spin systems composed of tetrahedral spin
clusters. For a class of such models, we found various exact low-lying
excitations; some of them are responsible for the first-order transition
between two different ground states formed by local singlets. Moreover, we find
that there are two different kinds of magnetization plateaus which are
separated by a first-order transition.Comment: To appear in Phys.Rev.B (Issue 01 August 2002). A short comment is
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Attenuation of ischemic liver injury by prostaglandin E<inf>1</inf> analogue, misoprostol, and prostaglandin I<inf>2</inf> analogue, OP-41483
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects. This study investigated whether misoprostol, prostaglandin E1 analogue, and OP-41483, prostaglandin I2 analogue, which have fewer adverse effects with a longer half-life, attenuate ischemic liver damage. Study Design: Thirty beagle dogs underwent 2 hours of hepatic vascular exclusion using venovenous bypass. Misoprostol was administered intravenously for 30 minutes before ischemia and for 3 hours after reperfusion. OP-41483 was administered intraportally for 30 minutes before ischemia (2 μg/kg/min) and for 3 hours after reperfusion (0.5 μg/kg/min). Animals were divided into five groups: untreated control group (n = 10); high-dose misoprostol (total 100 μg/kg) group (MP-H, n = 5); middle-dose misoprostol (50 μg/kg) group (MP-M, n = 5); low-dose misoprostol (25 μg/kg) group (MP-L, n = 5); and OP-41483 group (OP, n = 5). Animal survival, hepatic tissue blood flow (HTBF), liver function, and histology were analyzed. Results: Two-week animal survival rates were 30% in control, 60% in MP-H, 100% in MP-M, 80% in MP-L, and 100% in OP. The treatments with prostaglandin analogues improved HTBF, and attenuated liver enzyme release, adenine nucleotrides degradation, and histologic abnormalities. In contrast to the MP-H animals that exhibited unstable cardiovascular systems, the MP- M, MP-L, and OP animals experienced only transient hypotension. Conclusions: These results indicate that misoprostol and OP-41483 prevent ischemic liver damage, although careful dose adjustment of misoprostol is required to obtain the best protection with minimal side effects
Attenuation of ischemic liver injury by monoclonal anti-endothelin antibody, awETN40
Background: Enhanced production of endothelin-1 (ET1), vasoconstrictive 21 amino acids produced by endothelial cells during ischemia and after reperfusion of the liver, is known to cause sinusoidal constriction and microcirculatory disturbances, which lead to severe tissue damage. Using a 2- hour hepatic vascular exclusion model in dogs, we tested our hypothesis that neutralization of ET-1 by monoclonal anti-ET-1 and anti-ET-2 antibody (AwETN40) abates vascular dysfunction and ameliorates ischemia/reperfusion injury of the liver. Study Design: After skeletonization, the liver was made totally ischemic by cross-clamping the portal vein, the hepatic artery, and the vena cava (above and below the liver). Venovenous bypass was used to decompress splanchnic and inferior systemic congestion. AwETN40, 5 mg/kg, was administered intravenously 10 minutes before ischemia (treatment group, n = 5). Nontreated animals were used as controls (control group, n = 10). Animal survival, hepatic tissue blood flow, liver function tests; total bile acid, high-energy phosphate, ET-1 levels, and liver histopathology were studied. Results: Treatment with AwETN40 improved 2-week animal survival from 30% to 100%. Hepatic tissue blood flow after reperfusion was significantly higher in the treatment group. The treatment significantly attenuated liver enzyme release, total bile acid, and changes in adenine nucleotides. Immunoreactive ET-1 levels in the hepatic venous blood of the control group showed a significant increase and remained high for up to 24 hours after reperfusion. Histopathologic alterations were significantly lessened in the treatment group. Conclusions: These results indicate that ET-1 is involved in ischemia/reperfusion injury of the liver, which can be ameliorated by the monoclonal anti-ET-1 and antiET-2 antibody AwETN40
Dilute-Bose-Gas Approach to ground state phases of 3D quantum helimagnets under high magnetic field
We study high-field phase diagram and low-energy excitations of
three-dimensional quantum helimagnets. Slightly below the saturation field, the
emergence of magnetic order may be mathematically viewed as Bose-Einstein
condensation (BEC) of magnons. The method of dilute Bose gas enables an
unbiased quantitative analysis of quantum effects in three-dimensional
helimagnets and thereby three phases are found: cone, coplanar fan and an
attraction-dominant one. To investigate the last phase, we extend the usual BEC
approach so that we can handle 2-magnon bound states. In the case of 2-magnon
BEC, the transverse magnetization vanishes and long-range order occurs in the
quadrupolar channel (spin-nematic phase). As an application, we map out the
phase diagram of a 3D helimagnet which consists of frustrated J1-J2 chains
coupled by an interchain interaction J3.Comment: 4pages, 3figures, International Conference on Magnetism (ICM) 2009
(Karlsruhe, Germany, July 26-31, 2009)
Magnetization plateaus as insulator-superfluid transitions in quantum spin systems
We study the magnetization process in two-dimensional S=1/2 spin systems, to
discuss the appearance of a plateau structure. The following three cases are
considered: (1) the Heisenberg antiferromagnet and multiple-spin exchange model
on the triangular lattice, (2) Shastry-Sutherland type lattice, [which is a
possible model for SrCu2(BO3)2,] (3) 1/5-depleted lattice (for CaV4O9). We find
in these systems that magnetization plateaus can appear owing to a transition
from superfluid to a Mott insulator of magnetic excitations. The plateau states
have CDW order of the excitations. The magnetizations of the plateaus depend on
components of the magnetic excitations, range of the repulsive interaction, and
the geometry of the lattice.Comment: 5 pages, RevTeX, 7 figures, note and reference adde
Magnetization Plateau of an S=1 Frustrated Spin Ladder
We study the magnetization plateau at 1/4 of the saturation magnetization of
the S=1 antiferromagnetic spin ladder both analytically and numerically, with
the aim of explaining recent experimental results on BIP-TENO by Goto et al. We
propose two mechanisms for the plateau formation and clarify the plateau phase
diagram on the plane of the coupling constants between spins
Ground-state phase diagram and magnetic properties of a tetramerized spin-1/2 J_1-J_2 model: BEC of bound magnons and absence of the transverse magnetization
We study the ground state and the magnetization process of a spin-1/2
- model with a plaquette structure by using various methods. For
small inter-plaquette interaction, this model is expected to have a spin-gap
and we computed the first- and the second excitation energies. If the gap of
the lowest excitation closes, the corresponding particle condenses to form
magnetic orders. By analyzing the quintet gap and magnetic interactions among
the quintet excitations, we find a spin-nematic phase around
due to the strong frustration and the quantum effect. When high magnetic moment
is applied, not the spin-1 excitations but the spin-2 ones soften and dictate
the magnetization process. We apply a mean-field approximation to the effective
Hamiltonian to find three different types of phases (a conventional BEC phase,
``striped'' supersolid phases and a 1/2-plateau). Unlike the BEC in spin-dimer
systems, this BEC phase is not accompanied by transverse magnetization.
Possible connection to the recently discovered spin-gap compound (CuCl)LaNb2O7
is discussed.Comment: 18pages, 17figures; title changed, typos correcte
Massive and Massless Behavior in Dimerized Spin Ladders
We investigate the conditions under which a gap vanishes in the spectrum of
dimerized coupled spin-1/2 chains by means of Abelian bosonization and Lanczos
diagonalization techniques. Although both interchain () and dimerization
() couplings favor a gapful phase, it is shown that a suitable choice
of these interactions yields massless spin excitations. We also discuss the
influence of different arrays of relative dimerization on the appearance of
non-trivial magnetization plateaus.Comment: 5 pages, RevTex, 5 Postscript figure
Do Solar Neutrino Experiments Imply New Physics?
None of the 1000 solar models in a full Monte Carlo simulation is consistent
with the results of the chlorine or the Kamiokande experiments. Even if the
solar models are forced artifically to have a \b8 neutrino flux in agreeement
with the Kamiokande experiment, none of the fudged models agrees with the
chlorine observations. The GALLEX and SAGE experiments, which currently have
large statistical uncertainties, differ from the predictions of the standard
solar model by and , respectively.Comment: 7 pages (figures not included), Institute for Advanced Study number
AST 92/51. For a hard copy with the figures, write: [email protected]
Magnetization plateaux in dimerized spin ladder arrays
We investigate the ground state magnetization plateaux appearing in spin 1/2
two-leg ladders built up from dimerized antiferromagnetic Heisenberg chains and
dimerized zig-zag interchain couplings. Using both Abelian bosonization and
Lanczos methods we find that the system yields rather unusual plateaux and
exhibits massive and massless phases for specific choices or ``tuning'' of
exchange interactions. The relevance of this behavior in the study of
NH_4CuCl_3 is discussed.Comment: 9 pages, RevTeX, 11 postscript figure
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