8,315 research outputs found
Elucidating the role of hyperfine interactions on organic magnetoresistance using deuterated aluminium tris(8-hydroxyquinoline)
Measurements of the effect of a magnetic field on the light output and
current through an organic light emitting diode made with deuterated aluminium
tris(8-hydroxyquinoline) have shown that hyperfine coupling with protons is not
the cause of the intrinsic organic magnetoresistance. We suggest that
interactions with unpaired electrons in the device may be responsible.Comment: Submitte
Coplanar Circumbinary Debris Disks
We present resolved Herschel images of circumbinary debris disks in the alpha
CrB (HD139006) and beta Tri (HD13161) systems. We find that both disks are
consistent with being aligned with the binary orbital planes. Though secular
perturbations from the binary can align the disk, in both cases the alignment
time at the distances at which the disk is resolved is greater than the stellar
age, so we conclude that the coplanarity was primordial. Neither disk can be
modelled as a narrow ring, requiring extended radial distributions. To satisfy
both the Herschel and mid-IR images of the alpha CrB disk, we construct a model
that extends from 1-300AU, whose radial profile is broadly consistent with a
picture where planetesimal collisions are excited by secular perturbations from
the binary. However, this model is also consistent with stirring by other
mechanisms, such as the formation of Pluto-sized objects. The beta Tri disk
model extends from 50-400AU. A model with depleted (rather than empty) inner
regions also reproduces the observations and is consistent with binary and
other stirring mechanisms. As part of the modelling process, we find that the
Herschel PACS beam varies by as much as 10% at 70um and a few % at 100um. The
70um variation can therefore hinder image interpretation, particularly for
poorly resolved objects. The number of systems in which circumbinary debris
disk orientations have been compared with the binary plane is now four. More
systems are needed, but a picture in which disks around very close binaries
(alpha CrB, beta Tri, and HD 98800, with periods of a few weeks to a year) are
aligned, and disks around wider binaries (99 Her, with a 50 yr period) are
misaligned, may be emerging. This picture is qualitatively consistent with the
expectation that the protoplanetary disks from which the debris emerged are
more likely to be aligned if their binaries have shorter periods.Comment: accepted to MNRA
Acute Oxygen-Sensing via Mitochondria-Generated Temperature Transients in Rat Carotid Body Type I Cells
The Carotid Bodies (CB) are peripheral chemoreceptors that detect changes in arterial oxygenation and, via afferent inputs to the brainstem, correct the pattern of breathing to restore blood gas homeostasis. Herein, preliminary evidence is presented supporting a novel oxygen-sensing hypothesis which suggests CB Type I cell “hypoxic signaling” may in part be mediated by mitochondria-generated thermal transients in TASK-channel-containing microdomains. Distances were measured between antibody-labeled mitochondria and TASK-potassium channels in primary rat CB Type I cells. Sub-micron distance measurements (TASK-1: 0.33 ± 0.04 µm, n = 47 vs TASK-3: 0.32 ± 0.03 µm, n = 54) provided evidence for CB Type I cell oxygen-sensing microdomains. A temperature-sensitive dye (ERthermAC) indicated that inhibition of mitochondrial activity in isolated cells caused a rapid and reversible inhibition of mitochondrial thermogenesis and thus temperature in these microdomains. Whole-cell perforated-patch current-clamp electrophysiological recordings demonstrated sensitivity of resting membrane potential (Vm) to temperature: lowering bath temperature from 37°C to 24°C induced consistent and reversible depolarizations (Vm at 37°C: -48.4 ± 4.11 mV vs 24°C: -31.0 ± 5.69 mV; n = 5; p \u3c 0.01). These data suggest that hypoxic inhibition of mitochondrial thermogenesis may play an important role in oxygen chemotransduction in the CB. A reduction in temperature within cellular microdomains will inhibit plasma membrane ion channels, influence the balance of cellular phosphorylation–dephosphorylation, and may extend the half-life of reactive oxygen species. The characterization of a thermosensory chemotransduction mechanism, that may also be used by other oxygen-sensitive cell types and may impact multiple other chemotransduction mechanisms is critical if we are to fully understand how the CBs, and potentially other oxygen-sensitive cells, respond to hypoxia
Reconciling Semiclassical and Bohmian Mechanics: II. Scattering states for discontinuous potentials
In a previous paper [J. Chem. Phys. 121 4501 (2004)] a unique bipolar
decomposition, Psi = Psi1 + Psi2 was presented for stationary bound states Psi
of the one-dimensional Schroedinger equation, such that the components Psi1 and
Psi2 approach their semiclassical WKB analogs in the large action limit.
Moreover, by applying the Madelung-Bohm ansatz to the components rather than to
Psi itself, the resultant bipolar Bohmian mechanical formulation satisfies the
correspondence principle. As a result, the bipolar quantum trajectories are
classical-like and well-behaved, even when Psi has many nodes, or is wildly
oscillatory. In this paper, the previous decomposition scheme is modified in
order to achieve the same desirable properties for stationary scattering
states. Discontinuous potential systems are considered (hard wall, step, square
barrier/well), for which the bipolar quantum potential is found to be zero
everywhere, except at the discontinuities. This approach leads to an exact
numerical method for computing stationary scattering states of any desired
boundary conditions, and reflection and transmission probabilities. The
continuous potential case will be considered in a future publication.Comment: 18 pages, 8 figure
Variabilité des populations de salmonidés en eau courante : étude de la variance liée à différentes échelles spatiales ou temporelles et implications pour les modèles d'habitat
Ethanol and Opioids Do Not Act Synergistically To Depress Excitation in Carotid Body Type I Cells
The combination of opioids and ethanol can synergistically depress breathing and the acute ventilatory response to hypoxia. Multiple studies have shown that the underlying mechanisms for this may involve calcium channel inhibition in central neurons. But we have previously identified opioid receptors in the carotid bodies and shown that their activation inhibits calcium influx into the chemosensitive cells. Given that the carotid bodies contribute to the drive to breathe and underpin the acute hypoxic ventilatory response, we hypothesized that ethanol and opioids may act synergistically in these peripheral sensory organs to further inhibit calcium influx and therefore inhibit ventilation. Methods
Carotid bodies were removed from 56 Sprague–Dawley rats (1021 days old) and then enzymatically dissociated to allow calcium imaging of isolated chemosensitive type I cells. Cells were stimulated with high K+ in the presence and absence of the µ-opioid agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) (10 µM), a maximal sublethal concentration of ethanol (3 g L-1, 65.1 mM) or a combination of both. Results
DAMGO alone significantly inhibited Ca2+ influx but this effect was not potentiated by the high concentration of ethanol. Conclusion
These results indicate for the first time that while opioids may suppress breathing via an action at the level of the carotid bodies, ethanol is unlikely to potentiate inhibition via this pathway. Thus, the synergistic effects of ethanol and opioids on ventilatory parameters are likely mediated by central rather than peripheral actions
Quantum vortices and trajectories in particle diffraction
We investigate the phenomenon of the diffraction of charged particles by thin
material targets using the method of the de Broglie-Bohm quantum trajectories.
The particle wave function can be modeled as a sum of two terms
. A thin separator exists between the
domains of prevalence of the ingoing and outgoing wavefunction terms. The
structure of the quantum-mechanical currents in the neighborhood of the
separator implies the formation of an array of \emph{quantum vortices}. The
flow structure around each vortex displays a characteristic pattern called
`nodal point - X point complex'. The X point gives rise to stable and unstable
manifolds. We find the scaling laws characterizing a nodal point-X point
complex by a local perturbation theory around the nodal point. We then analyze
the dynamical role of vortices in the emergence of the diffraction pattern. In
particular, we demonstrate the abrupt deflections, along the direction of the
unstable manifold, of the quantum trajectories approaching an X-point along its
stable manifold. Theoretical results are compared to numerical simulations of
quantum trajectories. We finally calculate the {\it times of flight} of
particles following quantum trajectories from the source to detectors placed at
various scattering angles , and thereby propose an experimental test of
the de Broglie - Bohm formalism.Comment: 17 pages, 7 figures, accepted by IJB
The debris disk - terrestrial planet connection
The eccentric orbits of the known extrasolar giant planets provide evidence
that most planet-forming environments undergo violent dynamical instabilities.
Here, we numerically simulate the impact of giant planet instabilities on
planetary systems as a whole. We find that populations of inner rocky and outer
icy bodies are both shaped by the giant planet dynamics and are naturally
correlated. Strong instabilities -- those with very eccentric surviving giant
planets -- completely clear out their inner and outer regions. In contrast,
systems with stable or low-mass giant planets form terrestrial planets in their
inner regions and outer icy bodies produce dust that is observable as debris
disks at mid-infrared wavelengths. Fifteen to twenty percent of old stars are
observed to have bright debris disks (at wavelengths of ~70 microns) and we
predict that these signpost dynamically calm environments that should contain
terrestrial planets.Comment: Contribution to proceedings of IAU 276: Astrophysics of Planetary
System
Tug-of-war between stretching and bending in living cell sheets
The balance between stretching and bending deformations characterizes shape transitions of thin elastic sheets. While stretching dominates the mechanical response in tension, bending dominates in compression after an abrupt buckling transition. Recently, experimental results in suspended living epithelial monolayers have shown that, due to the asymmetry in surface stresses generated by molecular motors across the thickness
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of the epithelium, the free edges of such tissues spontaneously curl out-of-plane, stretching the sheet in-plane as a result. This suggests that a competition between bending and stretching sets the morphology of the tissue margin. In this paper, we use the framework of non-Euclidean plates to incorporate active pre-strain and spontaneous curvature to the theory of thin elastic shells. We show that, when the spontaneous curvature of the sheet scales like
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, stretching and bending energies have the same scaling in the limit of a vanishingly small thickness and therefore both compete, in a way that is continuously altered by an external tension, to define the three-dimensional shape of the tissue
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