702 research outputs found
First Amendment uses of public space: Manipulation through design?
The concept of the free exchange of ideas, as embodied in the First Amendment of the U.S. Constitution, underpins our notion of a government that works not by consensus or fiat, but by conflict between differing opinions and resolution by secret ballot. Part and parcel of that concept is that not only the vote but the information that leads to decisions in the country ought to be open to all and all should be able to express their opinions. In this way anyone may be able to· Influence their fellow citizens, regardless of the speaker's resources and station in life.</p
Why the fair innings argument is not persuasive
The fair innings argument (FIA) is frequently put forward as a justification for denying elderly patients treatment when they are in competition with younger patients and resources are scarce. In this paper I will examine some arguments that are used to support the FIA. My conclusion will be that they do not stand up to scrutiny and therefore, the FIA should not be used to justify the denial of treatment to elderly patients, or to support rationing of health care by age. There are six issues arising out of the FIA which are to be addressed. First, the implication that there is such a thing as a fair share of life. Second, whether it makes sense to talk of a fair share of resources in the context of health care and the FIA. Third, that 'fairness' is usually only mentioned with regard to the length of a person's life, and not to any other aspect of it. Fourth, if it is sensible to discuss the merits of the FIA without taking account of the 'all other things being equal' argument. Fifth, the difference between what is unfair and what is unfortunate. Finally, that it is tragic if a young person dies, but only unfortunate if an elderly person does
Bringing pupils into the ORBYTS of research
publishersversionPeer reviewe
HIGHER-ORDER REGULARITY FOR THE SOLUTIONS OF SOME DEGENERATE QUASI-LINEAR ELLIPTIC-EQUATIONS IN THE PLANE
Published versio
Preserving Differential Privacy in Convolutional Deep Belief Networks
The remarkable development of deep learning in medicine and healthcare domain
presents obvious privacy issues, when deep neural networks are built on users'
personal and highly sensitive data, e.g., clinical records, user profiles,
biomedical images, etc. However, only a few scientific studies on preserving
privacy in deep learning have been conducted. In this paper, we focus on
developing a private convolutional deep belief network (pCDBN), which
essentially is a convolutional deep belief network (CDBN) under differential
privacy. Our main idea of enforcing epsilon-differential privacy is to leverage
the functional mechanism to perturb the energy-based objective functions of
traditional CDBNs, rather than their results. One key contribution of this work
is that we propose the use of Chebyshev expansion to derive the approximate
polynomial representation of objective functions. Our theoretical analysis
shows that we can further derive the sensitivity and error bounds of the
approximate polynomial representation. As a result, preserving differential
privacy in CDBNs is feasible. We applied our model in a health social network,
i.e., YesiWell data, and in a handwriting digit dataset, i.e., MNIST data, for
human behavior prediction, human behavior classification, and handwriting digit
recognition tasks. Theoretical analysis and rigorous experimental evaluations
show that the pCDBN is highly effective. It significantly outperforms existing
solutions
Solidification behavior of intensively sheared hypoeutectic Al-Si alloy liquid
The official published version of this article can be found at the link below.The effect of the processing temperature on the microstructural and mechanical properties of Al-Si (hypoeutectic) alloy solidified from intensively sheared liquid metal has been investigated systematically. Intensive shearing gives a significant refinement in grain size and intermetallic particle size. It also is observed that the morphology of intermetallics, defect bands, and microscopic defects in high-pressure die cast components are affected by intensive shearing the liquid metal. We attempt to discuss the possible mechanism for these effects.Funded by the EPSRC
Deformation of the three-term recursion relation and the generation of new orthogonal polynomials
We find solutions for a linear deformation of the symmetric three-term
recursion relation. The orthogonal polynomials of the first and second kind
associated with the deformed relation are obtained. The new density (weight)
function is written in terms of the original one and the deformation
parameters.Comment: 12 pages, 3 figure
Multiphoton radiative recombination of electron assisted by laser field
In the presence of an intensive laser field the radiative recombination of
the continuum electron into an atomic bound state generally is accompanied by
absorption or emission of several laser quanta. The spectrum of emitted photons
represents an equidistant pattern with the spacing equal to the laser
frequency. The distribution of intensities in this spectrum is studied
employing the Keldysh-type approximation, i.e. neglecting interaction of the
impact electron with the atomic core in the initial continuum state. Within the
adiabatic approximation the scale of emitted photon frequencies is subdivided
into classically allowed and classically forbidden domains. The highest
intensities correspond to emission frequencies close to the edges of
classically allowed domain. The total cross section of electron recombination
summed over all emitted photon channels exhibits negligible dependence on the
laser field intensity.Comment: 14 pages, 5 figures (Figs.2-5 have "a" and "b" parts), Phys.Rev.A
accepted for publication. Fig.2b is presented correctl
DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
Stabilization of mutant p53 (mutp53) in tumours greatly contributes to malignant progression. However, little is known about the underlying mechanisms and therapeutic approaches to destabilize mutp53. Here, through high-throughput screening we identify statins, cholesterol-lowering drugs, as degradation inducers for conformational or misfolded p53 mutants with minimal effects on wild-type p53 (wtp53) and DNA contact mutants. Statins preferentially suppress mutp53-expressing cancer cell growth. Specific reduction of mevalonate-5-phosphate by statins or mevalonate kinase knockdown induces CHIP ubiquitin ligase-mediated nuclear export, ubiquitylation, and degradation of mutp53 by impairing interaction of mutp53 with DNAJA1, a Hsp40 family member. Knockdown of DNAJA1 also induces CHIP-mediated mutp53 degradation, while its overexpression antagonizes statin-induced mutp53 degradation. Our study reveals that DNAJA1 controls the fate of misfolded mutp53, provides insights into potential strategies to deplete mutp53 through the mevalonate pathway–DNAJA1 axis, and highlights the significance of p53 status in impacting statins’ efficacy on cancer therapy
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