ROLE OF DIFFERENT NEURONAL POPULATIONS OF THE MEDIAL SEPTALAREA IN THE FORMATION OF THE HIPPOCAMPAL THETA RHYTHM

We have proposed the model of neural network of medial septal area. This nucleus acts as pacemaker of hippocampal theta rhythm and plays key role in the cognitive functions of hippocampus such as attention and memory. We have supposed that synchronous burst mode of discharges can be formed by feed-back inhibition in subnetwork of glutamatergic and GABAergic neurons. We have shown that such sys­tem can involve projection to the hippocampus GABAergic neurons in burst rhythmic mode, which parameters are similar with experimental

CHOLINERGIC REGULATION OF NEURONAL ACTIVITY IN LIVING SLICES OF MEDIAL SEPTAL AREA IN HEALTHY AND EPILEPTIC BRAIN

We have researched reactions neurons in medial septal area in living slices of healthy and epileptic guinea pigs on modulators of cholinergic transmission. We discovered that cholinergic neurons generally influence on GABAergic system in control and it decreases at epilepsy