AMADEUS: Towards the AutoMAteD secUrity teSting

The proper configuration of systems has become a fundamental factor to avoid cybersecurity risks. Thereby, the analysis of cyber security vulnerabilities is a mandatory task, but the number of vul nerabilities and system configurations that can be threatened is ex tremely high. In this paper, we propose a method that uses software product line techniques to analyse the vulnerable configuration of the systems. We propose a solution, entitled AMADEUS, to enable and support the automatic analysis and testing of cybersecurity vulnerabilities of configuration systems based on feature models. AMADEUS is a holistic solution that is able to automate the analy sis of the specific infrastructures in the organisations, the existing vulnerabilities, and the possible configurations extracted from the vulnerability repositories. By using this information, AMADEUS generates automatically the feature models, that are used for rea soning capabilities to extract knowledge, such as to determine attack vectors with certain features. AMADEUS has been validated by demonstrating the capacities of feature models to support the threat scenario, in which a wide variety of vulnerabilities extracted from a real repository are involved. Furthermore, we open the door to new applications where software product line engineering and cybersecurity can be empowered.Ministerio de Ciencia, Innovación y Universidades RTI2018-094283-B-C33 (ECLIPSE)Junta de Andalucía P20-01224 (COPERNICA)Junta de Andalucía US-1381375 (METAMORFOSIS

Extracting novel facts from tables for Knowledge Graph completion

We propose a new end-to-end method for extending a Knowledge Graph (KG) from tables. Existing techniques tend to interpret tables by focusing on information that is already in the KG, and therefore tend to extract many redundant facts. Our method aims to find more novel facts. We introduce a new technique for table interpretation based on a scalable graphical model using entity similarities. Our method further disambiguates cell values using KG embeddings as additional ranking method. Other distinctive features are the lack of assumptions about the underlying KG and the enabling of a fine-grained tuning of the precision/recall trade-off of extracted facts. Our experiments show that our approach has a higher recall during the interpretation process than the state-of-the-art, and is more resistant against the bias observed in extracting mostly redundant facts since it produces more novel extractions

Synthesis of novel heterocyclic compounds from 6<i>H</i>-[2]-benzopyrano[4,3-c]quinolin-6-one and 2,3-diphenyl furo-[3,2-<i>c</i>]-quinolin-4-(5<i>H</i>)-one

2567-257211-Chloro-6H-[2]-benzopyrano-[4,3-c]quinolin-6-ones 1a-g/4-chloro-2,3-diphenyl-furo[3 ,2-c] quinoline 6a-g are obtained via the interaction of 6H-[2]-benzopyran [4,3-c]-quinoline-6, 11-[12]-dione / 2,3-diphenyl-furo[3,2-c]-quinolin-4-(5H)-one with a mixture of phosphorus pentachloride and phosphorusoxychloride. These chloro derivatives are further treated with sodium azide, o-phenylenediamine, anthranilic acid and benzoic acidhydrazide separately to afford novel hetrocyclic compounds 11-methyl-1,2,4-tetrazolo [1', 5', 1,2] quinolino [4,3-c]-benzopyran-8-ones 2a-g / 8-methyl-4,5-diphenyl-1,2,4-tetrazolo-[1 ',5': 1,2]-furo[3,2-c]-quinoline 7a-g, 13-methyl-imidazolo - [3',2':1,2]-quinolino-[4,3-c]benzopyran-10-ones 3a-g / 10-methyl-6, 7 -diphenyl-imidazolo [3',2':1,2]-furo[3,2-c]-quinoline 8a-g, 13- methylquinazilono-[3', 2',1,2] quinolino [4,3-c]-benzopyran-10, 16-diones 4a-g /10-methyl-6,7 -diphenyl-quinazilono [3', 2', 1,2]furo[3,2-c]quinolin-13-one 9a-g, 11-methyl-1-phenyl-triazolo- [3',4':1,2]quinolino [4,3-c]- benzopyran-8-ones 5a-g /8-methyl-1-phenyl-4,5-diphenyl-triazolo [3',4':1,2]furo-[3,,2-c]-quinoline 10a-g respectively. Some of these compounds have also been screened for their biological activity

Synthesis of some benzopyranoquinoline derivatives

29-324-Chlorocoumarins on condensation with anthranilic acid afford 4-(2' -carboxyphenylamino )-<span style="font-size:13.5pt;mso-bidi-font-size:7.5pt;font-family:Arial;mso-bidi-font-style: italic">2H-(<span style="font-size:14.5pt;mso-bidi-font-size: 8.5pt">1)- benzopyran-2-ones 1 which on cyclisation with polyphosphoric acid yield 7,12-dihydro-6H-[1]benzopyrano[<span style="font-size:14.0pt;mso-bidi-font-size:8.0pt;font-family:Arial;mso-bidi-font-style: italic">4,3-b<span style="font-size:14.5pt;mso-bidi-font-size: 8.5pt">]quinoline-6,7-diones 2. Compounds 1 on treatment with phosphoryl chloride yield 7-chlorobenzopyrano[4,3-b]quinolin-6(H)-ones <b style="mso-bidi-font-weight: normal">3. These chloro compounds on further treatment with various aromatic amines yield 7-anilinobenzopyrano[4,3-<i style="mso-bidi-font-style: normal">b]quinolin-6(H)-ones 4.<span style="font-size:16.0pt; mso-bidi-font-size:10.0pt"> </span

Synthesis and antimicrobial screening of 4<i style="">H</i>-2-acetyl-3-acetyamido furo[3,2-<i style="">c</i>] benzopyran 4-one, 11<i style="">H</i> -2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy-pyrimido [3,2-<i style="">d</i>]furo [3,2-<i style="">c</i>] benzopyran-11-one and 4<i style="">H</i>-2-acetyl-3-(3´-methyl-1´,2´,4´-triazol-4´-yl) furo[3,2-<i style="">c</i>] benzopyran 4-one

1558-1564 A suspension of 4H-2-acetyl-3-amino furo [3,2-c] benzopyran 4-one 5a-d in aqueous sodium hydroxide is treated with acetyl chloride to give 4H-2-acetyl-3-acetylamido furo[3,2-c] benzopyran 4-one 6a-d. The compounds 6a-d and hydrazine hydrate in absolute alcohol is refluxed to give 11H-2,4-dimethyl-3,4-dihydro-3-amino-4-hydroxy-pyrimido[3,2-d] furo [3,2-c]benzopyran-11-one 7a-d which in formic acid is refluxed for 5 hr to give 4H-2-acetyl-3-(3´-methyl-1´,2´,4´-triazol-4´-yl) furo[3,2-c] benzopyran 4-one 8a-d. The structures of all these compounds have been established on the basis of the spectral and analytical data. All compounds have showed good antimicrobial activity

Synthesis and antimicrobial screening of 4H-2-benzoyl-3-hydroxy-3-methyl-2-phenyl 2,3-dihydro-furo[3,2-c]benzopyran-4-one

128-1333-Acetyl-4-hydroxy-2H[1]benzopyran-2-one 2a-d has been treated with bromodeoxybenzoin in NaOH, THF:HMPA to give 4H-2-benzoyl-3-hydroxy-3-methyl-2-phenyl 2,3-dihydro-furo[3,2-c] benzopyran-4-one 3a-d. This on treatment with aqueous HCl in presence of dioxane gives 4H-3-methyl-2-phenyl furo[3,2-c] benzopyran-4-one 4a-d through acid catalysed 1,2-elimination. All compounds have been screened for antimicrobial activity. They do not show significant activity

Synthesis and antimicrobial screening of 5<i style="">H</i>,7<i style="">H</i>-<i style="">N</i>-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzimidazo[5,6-<i style="">c</i>]­furan and 5<i style="">H</i>,7<i style="">H</i>-<i style="">N</i>-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetrahydro benzimidazo[5,6-<i style="">c</i>]pyrrole

314-317The Schiff bases 2a-d of 6-aminocoumarins 1a-d on reaction with 4-benzylidene-2-phenyloxazolin-5-one in DMF and catalytic amount of pyridine afford 4-benzylidene-3-(coumarin-6-yl)-2-phenylimidazolin-5-ones 3a-d which on further Wittig reaction yield the corresponding 4-benzylidene-3-(coumarin-6-yl)-5-methylene-2-phenylimidazolines 4a-d. Compounds 4a-d on Diel’s-Alder reaction with maleic anhydride and N-(7-methoxy-4-methylcoumarin-6-yl)maleimide separately give 5H,7H-N-(cou­marin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzi­mi­d­a­zo­(5,6-c)furans 5a-d and 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetra­hydro­­benzimidazo(5,6-c)pyrroles 6a-d respectively. The structures of the compounds have been established on the basis of the spectral and analytical data. All the compounds 3-6a-d have been screened for their antimicrobial activities and found to exhibit significant antibacterial and antifungal activities

Synthesis and reactions of pyranoquinolines

358-3626-Aminocoumarins 1a-c are refluxed with ethyl benzoylacetate 2 in toluene to give benzoyl-N-(6'-coumarinyl)acetamides 3a-c, which on cyclisation with PPA afforded pyranoquinolines 4a-c. These are further converted into chloropyranoquinolines 5a-c using PCl5 and POCl3. These chloro derivatives are further treated separately, with sodium azide, anthranilic acid, o-phenylenediamine and benzoic hydrazide to obtain novel heterocyclic compounds, 9H-9-oxo-6-phenyl[10]pyrano[3 ,2-f]quinoline[1' ,5': 1,2] tetrazoles 6a-c, 10H, 15H-10, 15-dioxo-7-phenyl[11]pyrano[3,2-f]quinolino[1',2': 1,2] quinozolines 7a-c, 10H-10-oxo-7-phenyl[11]pyrano[3 ,2-f]quinolino[1 ',2': 1,2] benzimidazoles 8a-c and 9H-2,6-diphenyl-9- oxo [10]pyrano [3,2-f] quinolinof [1',2': 1,2]triazoles 9a-c, respectively

Synthesis and Antimicrobial Screening of N-[Coumarin-6-ylamino]thiazolidinone and Spiro Indolo-thiazolidinone Derivatives.

1074-1078Condensation of N-[coumarin-6-yl]hydrazonoarylmethanes 3a-h obtained from the condensation of the coumarin-6-ylhydrazine hydrochloride 2a-d and aromatic aldehydes, on treatment with mercaptoacetic acid in dry 1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride yields N-[coumarin-6-ylamino]-2-arylthiazolidin-4(H)-ones 4a-h. While, coumarin-6-ylhydrazine hydrochloride 2a-d on condensation with isatin in situ yields corresponding 1,2-dihydro-3-[coumarin-6-ylhydrazono]indol-2-ones 5a-d. Compound 5a-d on treatment with mercaptoacetic acid in dry 1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride affords N-[coumarin-6-ylamino]spiro-[3H-indole-(1H,2H)-3,2-(4H)-thiazolidine]-2,4-diones 6a-d. The structures of the compounds 3, 4, and 6 have been confirmed on the basis of their spectral and analytical data. The above compounds are screened for their antimicrobial activities and have been found to exhibit significant antibacterial and antifungal activities

Synthesis of biologically active thiazolo-benzopyranyl-<i>s</i>-triazine derivatives

621-6266-Amino-2-oxo-2H [1]-benzopyran on oxidative cyclisation with potassium thiaocynate, acetic acid and bromine at 0-5°C gives 2-amino-7H [6]- thiazolo [5,4-d] benzopyran-7-one 1, which on treatment with cyanuric chloride in alcohol gives 2-(2'-amino-7'-oxo-7' H [6']- thiazolo [5', 4'-d] benzopyranyl)-4-6-dichloro-s-triazine 2. 6-Amino-2-oxo-2H [1]-benzopyran on refluxing with ammonium thiocynate in hydrochloric acid and ethanol gives 6-thioureido-2H [1]-benzopyran-2-one 3. Compound 2 on refluxing with 3 in alcohol gives 2-(2'-amino-7'-oxo-7'H [6']- thiazolo [5', 4'-d] benzopyranyl)-4-(6"thioureido-2" H-[1"]-2" -oxo-benzopyranyl)-6-chloro-s-triazine 4. The similar reaction is repeated on 4 to give 2-(2'-amino-7' -oxo-7' H [6']- thiazolo [5', 4'-d] benzopyranyl)-4-(6"-thioureido-2" H [1"]-2"-oxo benzopyranyl)-6-(6'" -thioureido-2'" H[1"']-2'" -oxo-benzopyranyl)-s-triazine 5. The structures of all compounds are confirmed on the basis of analytical and spectral data. Some of the compounds show significant antibacterial activity