Evaluation of Gentamicin's Antimicrobial Resistance Pattern Against Uropathogens in a Tertiary Health Care Center in Dhaka City, Bangladesh

Treatment of UTI patients with aminoglycosides is a familiar incidence. Resistance of antibiotics is also a familiar incidence but it is alarming when it goes to a high ratio. The vital public health problem in developing country like Bangladesh is resistance of antibiotics to different types of bacteria causing UTI and the rates of these bacterial resistances are changing for various antibiotic therapy. Our aim was to assess the susceptible pattern of Gentamicin a drug of Aminoglycosides group against uropathogens. A total of 12943 urine samples were collected in 2016 (Jan-Dec) and out of which 1236 (9.55%) were bacteriologically positive out of these isolated  95.1% were gram negative and 4.9% gram positive organism. Male were found more prone to get UTI under 10 years and between 51-90 years of age and female were more affected in 10 to 50 years and over 90 years of age group. E. coli was the most prevalent (83.9%) isolate followed by Klebsiella spp. (6.7%), Staphylococcus aureus (2.6%), Pseudomonas spp. (2.2%), Enterococcus spp. (2.0%) and Proteus spp. (1.1%). The most predominant organism Acinetobacter spp. (100%) were found sensitive to Gentamicin in both male and female patients and Enterococcus spp. in male (62.5%) and female (58.8%) were found resistant.  Around 37.4% male and 32.5% female were found resistant to E.coli. Keywords: Gentamicin, Aminoglycosides, UTI, Resistance, Uropathogen. DOI: 10.7176/JHMN/67-08 Publication date:October 31st 201

Redox behaviour of chromium(VI) towards <img src='http://www.niscair.res.in/jinfo/smaller.gif' border=0>-mannose in the presence and absence of micelles and inorganic salts

2178-2188The kinetics and mechanism of the oxidation of -mannose by chromium(VI) in the absence and presence of sodium dodecyl sulfate(SDS) and polyoxylethylene t-octylphenol(TX-100) micelles have been investigated. Under pseudo-first-order conditions the reaction rate is of fractional- and first-order, respectively, in -mannose and oxidant. The reaction is catalyzed by the micelles which is due to favourable electrostatic/thermodynamic/ hydrophobic/hydrogen bonding between the reactants and anionic/nonionic micelles. From the observed kinetic data micelle-chromium(VI) binding constants(Ks) and micelle--mannose binding constants(KM) were calculated to be 86, 84 mol-1 dm3 and 58, 75 mol-1 dm3 for SDS and TX-100, respectively. The reaction is retarded by addition of inorganic salts (NaBr, LiBr, NH4Br) which is attributed to competition between salt cations and H+ from the reaction sites in the SDS micelles