281 research outputs found
"Dark energy" in the Local Void
The unexpected discovery of the accelerated cosmic expansion in 1998 has
filled the Universe with the embarrassing presence of an unidentified "dark
energy", or cosmological constant, devoid of any physical meaning. While this
standard cosmology seems to work well at the global level, improved knowledge
of the kinematics and other properties of our extragalactic neighborhood
indicates the need for a better theory. We investigate whether the recently
suggested repulsive-gravity scenario can account for some of the features that
are unexplained by the standard model. Through simple dynamical considerations,
we find that the Local Void could host an amount of antimatter
() roughly equivalent to the mass of a typical
supercluster, thus restoring the matter-antimatter symmetry. The antigravity
field produced by this "dark repulsor" can explain the anomalous motion of the
Local Sheet away from the Local Void, as well as several other properties of
nearby galaxies that seem to require void evacuation and structure formation
much faster than expected from the standard model. At the global cosmological
level, gravitational repulsion from antimatter hidden in voids can provide more
than enough potential energy to drive both the cosmic expansion and its
acceleration, with no need for an initial "explosion" and dark energy.
Moreover, the discrete distribution of these dark repulsors, in contrast to the
uniformly permeating dark energy, can also explain dark flows and other
recently observed excessive inhomogeneities and anisotropies of the Universe.Comment: 6 pages, accepted as a Letter to the Editor by Astrophysics and Space
Scienc
Finite time singularities in a class of hydrodynamic models
Models of inviscid incompressible fluid are considered, with the kinetic
energy (i.e., the Lagrangian functional) taking the form in 3D Fourier representation, where
is a constant, . Unlike the case (the usual Eulerian
hydrodynamics), a finite value of results in a finite energy for a
singular, frozen-in vortex filament. This property allows us to study the
dynamics of such filaments without the necessity of a regularization procedure
for short length scales. The linear analysis of small symmetrical deviations
from a stationary solution is performed for a pair of anti-parallel vortex
filaments and an analog of the Crow instability is found at small wave-numbers.
A local approximate Hamiltonian is obtained for the nonlinear long-scale
dynamics of this system. Self-similar solutions of the corresponding equations
are found analytically. They describe the formation of a finite time
singularity, with all length scales decreasing like ,
where is the singularity time.Comment: LaTeX, 17 pages, 3 eps figures. This version is close to the journal
pape
Reduction and Emergence in Bose-Einstein Condensates
A closer look at some proposed Gedanken-experiments on BECs promises to shed
light on several aspects of reduction and emergence in physics. These include
the relations between classical descriptions and different quantum treatments
of macroscopic systems, and the emergence of new properties and even new
objects as a result of spontaneous symmetry breaking
Conformational dynamics and internal friction in homopolymer globules: equilibrium vs. non-equilibrium simulations
We study the conformational dynamics within homopolymer globules by solvent-implicit Brownian dynamics simulations. A strong dependence of the internal chain dynamics on the Lennard-Jones cohesion strength Δ and the globule size N [subscript G] is observed. We find two distinct dynamical regimes: a liquid-like regime (for Δ Δ[subscript s] with slow internal dynamics. The cohesion strength Δ[subscript s] of this freezing transition depends on N G . Equilibrium simulations, where we investigate the diffusional chain dynamics within the globule, are compared with non-equilibrium simulations, where we unfold the globule by pulling the chain ends with prescribed velocity (encompassing low enough velocities so that the linear-response, viscous regime is reached). From both simulation protocols we derive the internal viscosity within the globule. In the liquid-like regime the internal friction increases continuously with Δ and scales extensive in N [subscript G] . This suggests an internal friction scenario where the entire chain (or an extensive fraction thereof) takes part in conformational reorganization of the globular structure.American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowshi
CARACTERIZAĂĂO BIOQUĂMICA DE AMOSTRAS DE Haemophilus parasuis ISOLADAS DE SUĂNOS NA REGIĂO SUL DO BRASIL
RANTES/CCL5 and risk for coronary events: Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies
Background: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. Methods and Findings: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±
Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers
Introduction: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. Methods: We used data from 15,252 BRCA1 and 8,211 BRCA2 carriers to analyze the associations between approximately 200,000 genetic variants on the iCOGS array and risk of BC subtypes defined by estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and triple-negative- (TN) status; morphologic subtypes; histological grade; and nodal involvement. Results: The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population. However, their associations with ER-positive BC in BRCA1 carriers were more consistent with the ER-positive as
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 Ă 10-20), ER-negative BC (P=1.1 Ă 10-13), BRCA1-associated BC (P=7.7 Ă 10-16) and triple negative BC (P-diff=2 Ă 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 Ă 10-3) and ABHD8 (P<2 Ă 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3âČ-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
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