Proton - Nucleus Interactions at 200-GeV/c

The investigation of interactions of hadrons with the nucleus in recent time became very important, and there is a hope that it can give the information about the systems produced in this process (lifetime, cross sections etc.) The nuclear photoemulsions are a good detector at the investigation of hadron-nucleus interactions due to a high spatial resolution and a possibility of detection of particles nearly at all energies that enables to study the characteristics of both fast and slow particles. The consistence of emulsion enables to obtain the characteristics of interactions both on light (CNO, <A> = 14) and on heavy(Ag,Br,<A> = 94) nuclei

Comparative analysis of perioperative period in children with different corrections of vesicoureteral reflux

The article presents the analysis of perioperative period of 52 children with different variants of correction of vesicoureteral reflux. It was based on acute-phase proteins amount, cytokines level and adhesion molecules content in blood and urine. the study revealed that if the correction is performed during the latent phase of chronic obstructive pyelonephritis the preference should be given to the endoscopic operations as they do not lead to acute inflammatory process in the urinary trac

Меченные технецием-99m низкомолекулярные ингибиторы простат-специфического мембранного антигена

High morbidity and mortality rates of prostate cancer (PCa) determine the requirement of looking for new methods of its early diagnosis. Methods of nuclear medicine have a special place in addressing this problem as they allow functional, metabolic and other processes imaging in body, which occur during the cancer development. This approach supposes the use of radiopharmaceuticals (RP), which are capable of selective binding to a specific biological target, for example, prostate-specific membrane antigen (PSMA), which is known to be overexpressed in PCa. Current development of new radiotracers for PCa imaging is focused on low molecular weight PSMA inhibitors due to their high specific binding to PSMA and rapid urinary excretion. Technetium-99m remains the appropriate radionuclide for diagnostic studies due to its optimal nuclear properties, ease of production and versatile coordination chemistry. Therefore, single-photon emission computed tomography (SPECT) imaging with 99mTc-PSMA radioligands can be a cost effective alternative to PET with 68Ga- or 18F-labeled RP. The aim of this review is to summarize and analyze currently available data on 99mTc-labeled low molecular weight PSMA inhibitors for metastatic PCa imaging.Особое место в ранней диагностике заболеваемости раком предстательной железы (РПЖ) занимают методы ядерной медицины, которые позволяют визуализировать функциональные, метаболические и иные процессы в организме, возникающие при наличии онкологического процесса. Благодаря высокоспецифичному связыванию с простат-специфическим мембранным антигеном (ПСМА) и быстрому выведению из организма с мочой именно низкомолекулярные ингибиторы ПСМА доминируют при разработке новых радиоиндикаторов для визуализации РПЖ. Технеций-99m остается наиболее подходящим радионуклидом для диагностических исследований благодаря своим оптимальным физико-химическим свойствам и удобству получения. В связи с этим однофотонная эмиссионная компьютерная томография (ОФЭКТ) с радиолигандами к ПСМА, меченными 99mTc, может быть экономически выгодной альтернативой ПЭТ с препаратами на основе 68Ga или 18F. Цель данного обзора обобщить и проанализировать имеющиеся на сегодняшний день данные о меченных 99mTc низкомолекулярных ингибиторах ПСМА, предназначенных для визуализации метастатического РПЖ

Coherent Production of Charged Particles on Nuclei by 400-GeV/c Protons

Topological cross sections {delta}{sub coh}{sup (n)} (n = 1,3,5 and 7) of coherent diffractive dissociation of 400 Gev/c protons on nuclei of photoemulsion elements have been measured. Topological cross sections increase in the energy range from 20 to 400 Gev/c. This growth is the most noticeable for multiprong topologies. The total cross section of diffractive coherent production also increases from 8 to 25 mb/nucleus in this energy range. The increasing of the average multiplicity of charged particles in reaction of coherent proton dissociates is consistent with the logarithmic law <n>{sub coh} = (90.25 {+-} 0.05) inp. + (1.3 {+-} 0.25)

Multiplicity of Charged Secondaries in Interactions of Protons in an Emulsion at 400-GeV/c

The preliminary results on multiplicities of charged secondaries in proton-nucleus interactions at 400 Gev/c are presented. Multiplicity of produced particles is consistent in the first approximation with the KNO scaling hypothesis for hadron-nucleus interactions. The relations between different moments of multiplicity distribution in proton-nucleons interactions at high energies are discussed too

The Multiplicity in Fragmentation and Pionisation Regions in p p Interactions at 200-GeV/c

Two BR-2 emulsion stacks 20cm x 10cm x 100 x 0,06 cm in size were irradiated by 200 Gev/c protons at the NAL accelerator in Batavia (US). The scanning along the track was performed. They observed 9339 inelastic interactions on the track length of 3303 m of primary protons