CASE para el diseño de aplicaciones hipermediales estructuradas

El objetivo fundamental de este proyecto es la implementación de un ambiente computarizado para asistir al diseño y construcción de aplicaciones Hipermediales, que se construirá como un CASE. Para esto es necesario contar con un modelo conceptual, que utilizaremos como fundamento para el desarrollo del CASE que cumpla con las características deseadas. Analizaremos algunos modelos conceptuales y elegiremos el que presente más utilidad para nuestro proyecto. Las características deseadas del CASE son: 1. Debe contar con un estado de diseño y un estado de implementación. 2. Facilitar el acceso entre los diferentes pasos de la metodología que soporta el CASE. 3. Los pasos del CASE estarán interconectados y diseñados de una manera consistente que facilite el trabajo de los desarrolladores. 4. Manejo de objetos a nivel instancia. 5. Se obtendrá como salida un prototipo de la aplicación Hipermedia. El prototipo permitirá a los desarrolladores experimentar con la aplicación implementada. 6. Una facilidad que flexibiliza el diseño para su posterior implementación, es la creación de objetos a partir de una Base de Datos existente pudiendo usar sus atributos en los niveles inferiores de diseño.Tesis digitalizada en SEDICI gracias a la colaboración de la Biblioteca de la Facultad de Informática.Facultad de Ciencias Exacta

CASE para el diseño de aplicaciones hipermediales estructuradas

El objetivo fundamental de este proyecto es la implementación de un ambiente computarizado para asistir al diseño y construcción de aplicaciones Hipermediales, que se construirá como un CASE. Para esto es necesario contar con un modelo conceptual, que utilizaremos como fundamento para el desarrollo del CASE que cumpla con las características deseadas. Analizaremos algunos modelos conceptuales y elegiremos el que presente más utilidad para nuestro proyecto. Las características deseadas del CASE son: 1. Debe contar con un estado de diseño y un estado de implementación. 2. Facilitar el acceso entre los diferentes pasos de la metodología que soporta el CASE. 3. Los pasos del CASE estarán interconectados y diseñados de una manera consistente que facilite el trabajo de los desarrolladores. 4. Manejo de objetos a nivel instancia. 5. Se obtendrá como salida un prototipo de la aplicación Hipermedia. El prototipo permitirá a los desarrolladores experimentar con la aplicación implementada. 6. Una facilidad que flexibiliza el diseño para su posterior implementación, es la creación de objetos a partir de una Base de Datos existente pudiendo usar sus atributos en los niveles inferiores de diseño.Tesis digitalizada en SEDICI gracias a la colaboración de la Biblioteca de la Facultad de Informática.Facultad de Ciencias Exacta

SARS-CoV-2 vaccination, Parkinson's disease, and other movement disorders: case series and short literature review

BACKGROUND: Several neurological complications have been reported following SARS-Cov-2 vaccination, without a clear causal relationship ever being verified, including some cases of worsening of Parkinson’s disease (PD) symptoms and new onset of movement disorders in non-parkinsonian patients. METHODS: We describe two new cases of PD patients treated with device-aided therapy who developed worsening of parkinsonian symptoms after receiving the third vaccine dose (booster). We also conducted a short review of the cases reported in literature of PD symptoms worsening and new onset of movement disorders in non-parkinsonian patients after SARS-Cov-2 vaccination. RESULTS: The first patient, a 46-year-old man implanted with bilateral Subthalamic Deep Brain Stimulation, experienced temporary motor and non-motor symptoms worsening after mRNA-1273 booster, improved after stimulation settings modification. The second patient, a 55-year-old man implanted with percutaneous endoscopic transgastric jejunostomy (PEG-J) for levodopa-carbidopa intestinal gel (LCIG) infusion experienced severe temporary worsening of dyskinesia and managed through temporary LCIG dose reduction. Other seven cases of vaccine-related movement disorder are currently reported in literature, four describing PD symptoms worsening and three the onset of new movement disorders in otherwise healthy people. CONCLUSION: Both our patients and the cases described so far completely recovered after few days with parkinsonian therapy modification, symptomatic treatment, or even spontaneously, underlining the transient and benign nature of side effects from vaccine. Patients should be reassured about these complications, manageable through a prompt evaluation by the reference neurologist. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-022-06182-w

Machine Learning for Mini-EUSO Telescope Data Analysis

Neural networks as well as other methods of machine learning (ML) are known to be highly efficient in different classification tasks, including classification of images and videos. Mini- EUSO is a wide-field-of-view imaging telescope that operates onboard the International Space Station since 2019 collecting data on miscellaneous processes that take place in the atmosphere of Earth in the UV range. Here we briefly present our results on the development of ML-based approaches for recognition and classification of track-like signals in the Mini-EUSO data, among them meteors, space debris and signals the light curves and kinematics of which are similar to those expected from extensive air showers generated by ultra-high-energy cosmic rays. We show that even simple neural networks demonstrate impressive performance in solving these tasks.Comment: 10 pages, 3 figures, ICRC2023 conferenc

UV telescope TUS on board Lomonosov satellite: Selected results of the mission

The Tracking Ultraviolet Setup (TUS) was the first orbital detector aimed to check the possibility of recording ultra-high energy cosmic rays (UHECRs) at E≳100 EeV by measuring the fluorescence signal of extensive air showers in the atmosphere. TUS was an experiment funded by the Russian Space Agency ROSCOSMOS, and it operated as a part of the scientific payload of the Lomonosov satellite since April 2016 till late 2017. During its mission, TUS registered almost 80,000 events in its main operation mode, with a few of them being sufficiently interesting to be more deeply scrutinized as they showed light profile and duration similar to UHECR events, even though much brighter. At the same time, the data acquired by TUS in different acquisition modes have been used to search for more exotic matter such us strangelets and nuclearites, and to measure occurrence, time profile and signal amplitude of different classes of transient luminous events among other scientific objectives, showing the interdisciplinary capability of a space-based observatory for UHECRs. In this paper, we report a selection of studies and results obtained with the TUS telescope which will be presented and placed in the contest of the present and future missions dedicated to the observation of UHECRs from space such as Mini-EUSO, K-EUSO and POEMMA

COVID-19 and Parkinson's disease: what do we know so far?

Background: Many studies on Parkinson’s disease (PD) patients affected by Coronavirus-disease-2019 (COVID-19) were recently published. However, the small sample size of infected patients enrolled in most studies did not allow to draw robust conclusions on the COVID-19 impact in PD. Objective: We aimed to assess whether the prevalence and outcome of COVID-19 in PD patients are different from those observed in the general population. Methods: We conducted a systematic review of studies reporting data on PD patients with a diagnosis of COVID-19 (PD-COVID+). We extracted prevalence, clinical-demographic data, outcome, and mortality. We also analyzed risk or protective factors based on comparisons between PD-COVID+ and control populations with PD without COVID-19 or without PD with COVID-19. Results: We included 16 studies reporting on a total of 11,325 PD patients, 1,061 with a confirmed diagnosis of COVID-19. The median infection prevalence ranged from 0.6% to 8.5%. PD-COVID+ patients had a median age of 74 and a disease duration of 9.4 years. Pooling all PD-COVID+ patients from included studies, 28.6% required hospitalization, 37.1% required levodopa dose increasing, and 18.9% died. The case fatality was higher in PD-COVID+ patients than the general population, with longer PD duration as a possible risk factor for worse outcome. Amantadine and vitamin D were proposed as potential protective factors. Conclusion: Available studies indicate a higher case fatality in PD patients affected by COVID-19 than the general population. Conversely, current literature does not definitively clarify whether PD patients are more susceptible to get infected. The potential protective role of vitamin D and amantadine is intriguing but deserves further investigation

Incidence of Second Primary Cancer in Transplanted Patients

Background. Solid organ transplanted patients have a three-to fourfold higher lifetime risk of developing a cancer than the general population. However, the incidence of a second primary cancer in transplanted patients has never been studied, despite the fact that the presence of regular follow-ups and the increased survival of these patients make them a very attractive model. Methods. We investigated the incidence of a second primary cancer (SPC) in 7,636 patients who underwent a kidney, liver, lung or heart transplant between 1970 and 2004, and were followed-up for 51,819 person-years. Results. During the follow-up, 499 subjects developed a first cancer (annual incidence: 98.6ϫ10,000 PY), and 22 of them developed a SPC (annual incidence: 3.9ϫ10,000 PY). The annual incidence of a SPC in the transplanted patients who developed a first cancer was 107.8ϫ10,000 PY, giving a standardized incidence ratio of 1.1 (95% CI: 0.83-1.41). Conclusions. This result shows that the incidence of the SPC was the same as the incidence of a first cancer. Our study does not indicate an increased risk of SPC in transplanted subjects who already suffered a first malignancy

Anxiety, depression and worries in advanced Parkinson Disease during COVID-19 pandemic

Background The psychological impact of the COVID-19 outbreak and lockdown on frail populations with advanced Parkinson disease (APD) and their caregivers may present with peculiar features and require specific interventions. Methods We enrolled here 100 APD patients and 60 caregivers. Seventy-four patients were treated with device-aided therapies (DAT) and 26 with standard medical treatment (SMT). Through a telephonic interview, subjects underwent the Hospital Anxiety and Depression Scale (HADS-A; HADS-D), and an ad hoc questionnaire to explore thoughts and emotions related to the pandemic. Results Depression was observed in 35% of APD patients and anxiety in 39%, with a significant reduction of the latter after the lockdown (p= 0.023). We found a significant correlation between the type of therapy and the HADS-A score (p= 0.004). Patients’ main worries were as follows: a possible higher risk of COVID-19 infection (25%), interruption of non-pharmacological treatments (35%), interruption of outpatient clinics (38%), PD complications related to COVID-19 (47%). Patients treated with DAT manifested worries about device-related issues and risk for caregivers’ infection. The 40% of caregivers showed anxiety, while the 21.7% of them showed depression. Conclusion Our study reveals a higher prevalence of anxiety and the presence of peculiar worries and needs in APD patients during the pandemic alongside psychological sequelae of their caregivers. These findings are important for neurologists and healthcare services to foster strategies for the management of psychological distress in both patients and caregivers