Cluster Computing and Performance Measurement

There is a continual demand for greater computational power from computer systems than is currently possible. Areas requiring great computational speed include numerical simulation of scientific and engineering problems. Such problems often need huge quantities of repetitive calculations on large amount of data to give valid results. Cluster computing offers many advantages as a highly cost-effective and often scalable approach for high-performance computing in general. To achieve the full potential of high performance computing systems, centralized configuration services are the starting point. For a large scale of projects, cluster computing is required where it is supposed to be optimized for the system topology and management of the project. This paper presents the consequences of using cluster computing and performance management and the consequences without this technology. The experimental results of this paper highlight the affects of the design of this service and provide a comprehensive performance analysis of the project

A laparoscopic management of Swyer syndrome in a woman with pure 46XY gonads and hypoplastic dysgenesis-a rare presentation

Swyer syndrome is also known as complete/pure gonadal dysgenesis & is associated with an absence of testicular differentiation in a phenotypic female with a 46, XY karyotype. A 23-year-old married girl had come with complaints of primary infertility. She was averagely built & nourished. She had well developed secondary sexual characteristics like  breast development,  axillary hairs, and  pubic hairs (Tanners stage 4) secondary to receiving HRT for getting  menses. External genitalia was of female type. Karyotype showed genotype of 46, XY. Magnetic resonance imaging revealed hypoplastic uterus with rudimentary fallopian tubes , and fibrotic gonad like tissue. A diagnosis of Swyer syndrome was made. The patient was started on hormonal replacement therapy. Dysgenetic streak gonads were removed laparoscopically . Pathologic examination revealed seminiferous tubules ,rete testis & epididymis without evidence of malignant transformation. The patient tolerated the procedure well . Thus laparoscopic prophylactic gonadectomy revealed to be an economical ,straightforward and simple procedure in this patient & risk of neoplasia could be prevented. 

Imaging in ovarian cancer

Ovarian cancer is the fifth most common cause of death from cancer in women after lung, breast, colon, and pancreatic cancer. The incidence of ovarian cancer rises continuously between the ages 30 and 70 years and peaks at 59 years of age. Ovarian cancer is more lethal than endometrial and cervical cancer combined due to delayed diagnosis.Owing to the lack of symptoms and early peritoneal dissemination, the tumour has spread outside the pelvis in approximately 70% of cases at the time of diagnosis. The stage at diagnosis is the most important prognostic factor. The 5-year survival rates drop from 93% in patients with localized disease to 28% in those with distant metastases. Bimanual pelvic exam and CA 125 levels have failed to allow consistent detection of ovarian malignancy.CA 125 is a high molecular weight glycoprotein recognised by the OC 125 monoclonal antibody (sensitivity & specificity is better with combination of TVS). Since the sensitivities of these techniques are below 50%, particularly ultrasonography, CT and MRI has become indispensable in detection and staging of ovarian malignancy

Sway Reduction of Tower Crane

Tower crane is a common fixture at any major construction site. They often rise hundreds of feet into the air, and can reach out just as far. Tower crane has a problem that a fast transfer of the load causes sway of the load. It takes a long time sometime to lift up and unload the load due to the wind and other disturbances. The objective of this project is to minimize the sway of the load suspended on the tower crane by developing a control method by using a concept of spherical pendulum and delayed position feedback. Develop equation for controller and solve using numerical simulation. From the result gained, the best method can be used to minimize the sway of the tower crane

DEVELOPMENT AND IN VITRO EVALUATION OF VALSARTAN-LOADED RESEALED ERYTHROCYTES

Objective: Resealed erythrocyte technique has attempts for preparation of valsartan loaded reservoir type using red blood cell as a carrier. Methods: The resealed erythrocytes were prepared by using glutaraldehyde as a cross-linking agent by Preswell dilution technique and sodium chloride as the medium has been made to predict mechanism of drug release and absorption based on the order of release. The prepared resealed erythrocytes was characterised as a percentage of cell recovery drug content, osmotic shock, turbulence fragility, osmotic fragility, in vitro drug release studies, and hemoglobin content study. Results: The result of the study showed that the resealed erythrocytes prepared with sodium chloride (9 %) showed biconcave shape, an assay of 6.5±0.4 %, osmotic shock (0.028±0.004 µg/ml), turbulence fragility of 0.228±0.046 µg/ml, and 44.38±5.54 % drug release in 8 h. The drug release kinetics was studied and found that release from spherical matrices, first-order model with non-fickian diffusion with and the dissolution occurs in planes that are parallel to the drug surface pattern. Conclusion: VaL administration could be avoided the number of drawbacks associated with systemic delivery and perhaps maintain a relatively constant plasma level during a lengthy course of treatment

Airway Management Outside the Operating Room

An anesthesiologist is an expert at airway management in the clinical environment. He or she has mastered knowledge of the anatomy and physiology of the normal and potentially abnormal airway. The environment of the operating room (OR) has been considered to be their most familiar area of work, where they feel most confident. Airway management outside this area is known to put patients at an increased risk of complications. This chapter addresses the important facets of this indispensable skill when used outside the operating room, taking into consideration both anesthesiologists and non-anesthesiologists as operators. Since the intensive care unit (ICU) is a similar environment to the OR, a separate chapter has been written for airway management in the ICU. Therefore, this chapter will concentrate on other areas outside the OR. It will not address resuscitation scenarios

Interstitial Nephritis Presenting as Acute Kidney Injury Following Ingestion of Alternative Medicine Containing Lead: A Case Report

Introduction: Some studies have shown that patients consuming alternate medicine can suffer from complications like acute kidney injury (AKI) due to heavy metal poisoning. The use of traditional ayurvedic herbal remedies may be difficult to identify as a source of toxicity, especially if the treating doctor is not aware of this habit, unless a detailed history is taken. In this report, we describe a patient who had consumed ayurvedic supplements for treating fever and abdominal pain and presented to our emergency department (ED) with AKI. Case presentation: A 24-year-old male presented to the ED with complaints of abdominal pain, fever and loose stools. His blood tests revealed AKI and he was started on emergency hemodialysis. His renal function improved after only one cycle of dialysis and he was discharged in a stable condition. Conclusion: Acute lead toxicity should be suspected in patients with abdominal and neurological dysfunction who have a history of chronic ayurvedic medicine intake and thus should be promptly treated. Physicians should rule out potential toxicity from these supplements and have a heightened level of suspicion for lead toxicity in patients presenting with abdominal pain and AKI without any obvious cause

Interstitial Nephritis Presenting as Acute Kidney Injury Following Ingestion of Alternative Medicine Containing Lead: A Case Report

Introduction: Some studies have shown that patients consuming alternate medicine can suffer from complications like acute kidney injury (AKI) due to heavy metal poisoning. The use of traditional ayurvedic herbal remedies may be difficult to identify as a source of toxicity, especially if the treating doctor is not aware of this habit, unless a detailed history is taken. In this report, we describe a patient who had consumed ayurvedic supplements for treating fever and abdominal pain and presented to our emergency department (ED) with AKI. Case presentation: A 24-year-old male presented to the ED with complaints of abdominal pain, fever and loose stools. His blood tests revealed AKI and he was started on emergency hemodialysis. His renal function improved after only one cycle of dialysis and he was discharged in a stable condition. Conclusion: Acute lead toxicity should be suspected in patients with abdominal and neurological dysfunction who have a history of chronic ayurvedic medicine intake and thus should be promptly treated. Physicians should rule out potential toxicity from these supplements and have a heightened level of suspicion for lead toxicity in patients presenting with abdominal pain and AKI without any obvious cause