A new mutation of LKB1 gene in a Japanese patient with Peutz-Jeghers syndrome.

Germline mutations of the LKB1 gene are associated with Peutz-Jeghers syndrome (PJS), which is characterized by mucocutaneous pigmentation and gastrointestinal hamartoma with an increased risk of cancer development. In this study, we have employed polymerase chain reaction and DNA sequencing analysis to characterize the LKB1 gene in a 25-year-old Japanese PJS patient. Direct sequence analyses revealed a novel single base deletion at nucleotide 844 in exon 6 (844delC) in one LKB1 allele, resulting in a frame shift and in the introduction of a premature termination codon in this mutated allele.</p

福祉＝自ら・参加・築く10: 社会保障の歩み[5]

Many specialists working in the field of the fractional calculus and its applications simply replace the integer differentiation and integration operators by their non-integer generalizations and do not give any serious justifications for this replacement. What kind of "Physics" lies in this mathematical replacement? Is it possible to justify this replacement or not for the given type of fractal and find the proper physical meaning? These or other similar questions are not discussed properly in the current papers related to this subject. In this paper new approach that relates to the procedure of the averaging of smooth functions on a fractal set with fractional integrals is suggested. This approach contains the previous one as a partial case and gives new solutions when the microscopic function entering into the structural-factor does not have finite value at N ≫ 1 (N is number of self-similar objects). The approach was tested on the spatial Cantor set having M bars with different symmetry. There are cases when the averaging procedure leads to the power-law exponent that does not coincide with the fractal dimension of the self-similar object averaged. These new results will help researches to understand more clearly the meaning of the fractional integral. The limits of applicability of this approach and class of fractal are specified. © 2013 Versita Warsaw and Springer-Verlag Wien