59 research outputs found
A multi-measure approach for assessing the performance of fMRI preprocessing strategies in resting-state functional connectivity
It is well established that head motion and physiological processes (e.g. cardiac and breathing activity) should be taken into consideration when analyzing and interpreting results in fMRI studies. However, even though recent studies aimed to evaluate the performance of different preprocessing pipelines there is still no consensus on the optimal strategy. This is partly due to the fact that the quality control (QC) metrics used to evaluate differences in performance across pipelines have often yielded contradictory results. Furthermore, preprocessing techniques based on physiological recordings or data decomposition techniques (e.g. aCompCor) have not been comprehensively examined. Here, to address the aforementioned issues, we propose a framework that summarizes the scores from eight previously proposed and novel QC metrics to a reduced set of two QC metrics that reflect the signal-to-noise ratio and the reduction in motion artifacts and biases in the preprocessed fMRI data. Using this framework, we evaluate the performance of three commonly used practices on the quality of data: 1) Removal of nuisance regressors from fMRI data, 2) discarding motion-contaminated volumes (i.e., scrubbing) before regression, and 3) low-pass filtering the data and the nuisance regressors before their removal. Using resting-state fMRI data from the Human Connectome Project, we show that the scores of the examined QC metrics improve the most when the global signal (GS) and about 17% of principal components from white matter (WM) are removed from the data. Finally, we observe a small further improvement with low-pass filtering at 0.20 Hz and milder variants of WM denoising, but not with scrubbing
Thoughts of Death Modulate Psychophysical and Cortical Responses to Threatening Stimuli
Existential social psychology studies show that awareness of one's eventual death profoundly influences human cognition and behaviour by inducing defensive reactions against end-of-life related anxiety. Much less is known about the impact of reminders of mortality on brain activity. Therefore we explored whether reminders of mortality influence subjective ratings of intensity and threat of auditory and painful thermal stimuli and the associated electroencephalographic activity. Moreover, we explored whether personality and demographics modulate psychophysical and neural changes related to mortality salience (MS). Following MS induction, a specific increase in ratings of intensity and threat was found for both nociceptive and auditory stimuli. While MS did not have any specific effect on nociceptive and auditory evoked potentials, larger amplitude of theta oscillatory activity related to thermal nociceptive activity was found after thoughts of death were induced. MS thus exerted a top-down modulation on theta electroencephalographic oscillatory amplitude, specifically for brain activity triggered by painful thermal stimuli. This effect was higher in participants reporting higher threat perception, suggesting that inducing a death-related mind-set may have an influence on body-defence related somatosensory representations
Dynamic cerebral autoregulation: different signal processing methods without influence on results and reproducibility
Nonlinear modeling of glucose metabolism: Comparison of parametric vs. nonparametric methods
Analysis of coupling phenomena in a TEM concentric array of applicators radiating into a layered biological tissue model
Bayesian model order selection for nonlinear system function expansions.
Orthonormal function expansions have been used extensively in the context of linear and nonlinear systems identification, since they result in a significant reduction in the number of required free parameters. In particular, Laguerre basis expansions of Volterra kernels have been used successfully for physiological systems identification, due to the exponential decaying characteristics of the Laguerre orthonormal basis and the inherent nonlinearities that characterize such systems. A critical aspect of the Laguerre expansion technique is the selection of the model structural parameters, i.e., polynomial model order, number of Laguerre functions in the expansion and value of the Laguerre parameter alpha, which determines the rate of exponential decay. This selection is typically made by trial-and-error procedures on the basis of the model prediction error. In the present paper, we formulate the Laguerre expansion technique in a Bayesian framework and derive analytically the posterior distribution of the alpha parameter, as well as the model evidence, in order to infer on the expansion structural parameters. We also demonstrate the performance of the proposed method by simulated examples and compare it to alternative statistical criteria for model order selection
Bayesian estimation of dynamic systems function expansions
Orthonormal function expansions have been used extensively in the context of linear and nonlinear systems identification, since they result in a significant reduction in the number of required free parameters. In particular, Laguerre basis expansions have been used in the context of biological/ physiological systems identification, due to the exponential decaying characteristics of the Laguerre orthonormal basis, the rate of which is determined by the Laguerre parameter α. A critical aspect of the Laguerre expansion technique is the selection of the model structural parameters, i.e., polynomial model order for nonlinear systems, number of Laguerre functions and value of the Laguerre parameter α. This selection is typically made by trial-and-error procedures on the basis of the model prediction error. In the present paper, we formulate the Laguerre expansion technique in a Bayesian framework. Based on this formulation, we derive analytically the posterior distribution of the α parameter and the model evidence, in order to perform model order selection. We also demonstrate the performance of the proposed method by simulated examples and compare it to alternative statistical criteria for model order selection. ©2010 IEEE
Nonlinear multivariate analysis of dynamic cerebral blood flow regulation in humans
The dynamic relationship between cerebral blood flow, arterial blood pressure and arterial CO2 is studied using the Laguerre-Volterra network methodology for modeling multiple-input nonlinear systems. Spontaneous beat-to-beat cerebral blood flow velocity and mean arterial blood pressure fluctuations, as well as breath-to-breath end-tidal CO2 fluctuations are analyzed and the Volterra kernels of the system are obtained. It is found that, while pressure changes explain most of the blood flow velocity variations, the inclusion of end-tidal CO2 fluctuations as an additional input variable can improve the prediction accuracy of the model output considerably. The model includes also nonlinear interactions between pressure and end-tidal CO2 and their impact on cerebral blood flow
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