Short review of the biomedical properties and application of magnesium alloys for bone tissue bioengineering

Aim: to review current scientific literature concerning the main advances and problems of magnesium (Mg) alloys for traumatology and orthopedics. Methodology of the study. Analytical review based the comprehensive investigation of public scientific and technological sources. Results of the study. Modern knowledge about classification, in vitro and in vivo biodegradation, biomechanics, local and general biocompatibilities, clinical efficacy, and hazards of infectious complications in conditions of osteosynthesis with implants made of Mg alloys with or without protective (anticorrosion and antimicrobial) coatings is presented. Conclusion. Fast degradation and a risk of periprosthetic infection strongly limit clinical application of implants made of Mg and its alloys. Development of novel Mg alloys and their modification by incorporating antimicrobial elements into their body or protective coating is a promising direction to control biomedical characteristics of Mg alloys

Саркоидоз как ассоциированное с метаболическим синдромом заболевание

The review summarizes and analyzes the results of domestic and major foreign studies of recent years concerning the prevalence of metabolic syndrome components and the explanation of their role in the mechanisms of sarcoidosis development. A deep understanding of the pathogenesis of metabolic syndrome (MS) in terms of the role in it of risk factors for a severe course and complications of most socially sensitive noncommunicable diseases clustered within MS can underly the development of effective pathogen-specific approaches to MS treatment.В обзоре обобщены и проанализированы результаты отечественных и крупных зарубежных исследований последних лет, касающихся изучения распространенности компонентов метаболического синдрома (МС) и объяснения их роли в механизмах развития саркоидоза. Глубокое понимание патогенеза данного заболевания с позиций участия в нем кластера факторов риска тяжелого течения и осложнений большинства социально значимых неинфекционных заболеваний, объединенных рамками МС, может лечь в основу разработки эффективных патогенетических подходов к лечению