Phototriggered Base Proliferation: A Highly Efficient Domino Reaction for Creating Functionally Photo-Screened Materials

Phototriggered base proliferation as a highly efficient domino reaction is presented for creating functionally photo-screened materials, providing a strategy for the photopolymerization of shadow areas via chemically diffuse amines toward the nonirradiated areas during polymerization. By integrating proliferated amines with a peroxide initiator (dibenzoyl peroxide, BPO), phototriggered self-propagating polymerization of acrylate monomers in three-dimensional space was achieved. The advantages of this approach lie in its enhanced photosensitivity, increased propagating velocity, and elevated double-bond conversion (90%) while reducing the local high temperature and the minimum BPO concentration that sustain a traveling front. Astonishingly, the propagating velocity and local maximum temperature can be well-modulated by varied BPO concentration and the appropriate amount of BA-BPD (1-(9-fluorenylmethoxycarbonyl)-4-benzylpiperidine) concentration, respectively. Finally, functionally photo-screened material containing carbon nanotubes was successfully prepared by phototriggered base proliferation reactions

Cobalt-Catalyzed Monoselective <i>Ortho</i>-C–H Functionalization of Carboxamides with Organoaluminum Reagent

A simple triphenylphosphine-ligated cobalt catalyst is reported for the direct <i>ortho</i>-C–H methylation and ethylation of aromatic, heteroaromatic, alkenyl, and even aliphatic carboxamides with inexpensive organoaluminum reagents in the presence of a cheap alkyl chloride as oxidant. This reaction shows monoselectivity in contrast with previously established C–H methylation methodologies

Exploring the Effect of Ligand-Originated MOF Isomerism and Methoxy Group Functionalization on Selective Acetylene/Methane and Carbon Dioxide/Methane Adsorption Properties in Two NbO-Type MOFs

Investigation of the impact of ligand-originated MOF (metal–organic framework) isomerism and ligand functionalization on gas adsorption is of vital importance because a study in this aspect provides valuable guidance for future fabrication of new MOFs exhibiting better performance. For the abovementioned purpose, two NbO-type ligand-originated MOF isomers based on methoxy-functionalized diisophthalate ligands were solvothermally constructed in this work. Their gas adsorption properties toward acetylene, carbon dioxide, and methane were systematically investigated, revealing their promising potential for the adsorptive separation of both acetylene/methane and carbon dioxide/methane gas mixtures, which are involved in the industrial processes of acetylene production and natural gas sweetening. In particular, compared to its isomer <b>ZJNU-58</b>, <b>ZJNU-59</b> displays larger acetylene and carbon dioxide uptake capacities as well as higher acetylene/methane and carbon dioxide/methane adsorption selectivities despite its lower pore volume and surface area, demonstrating a very crucial role that the effect of pore size plays in acetylene and carbon dioxide adsorption. In addition, the impact of ligand modification with a methoxy group on gas adsorption was also evaluated. <b>ZJNU-58</b> exhibits slightly lower acetylene and carbon dioxide uptake capacities but higher acetylene/methane and carbon dioxide/methane adsorption selectivities as compared to its parent compound NOTT-103. By contrast, enhanced adsorption selectivities and uptake capacities were observed for <b>ZJNU-59</b> as compared to its parent compound <b>ZJNU-73</b>. The results demonstrated that the impact of ligand functionalization with a methoxy group on gas adsorption might vary from MOF to MOF, depending on the chosen parent compound. The results might shed some light on understanding the impact of both ligand-originated MOF isomerism and methoxy group functionalization on gas adsorption

Exploring the Effect of Ligand-Originated MOF Isomerism and Methoxy Group Functionalization on Selective Acetylene/Methane and Carbon Dioxide/Methane Adsorption Properties in Two NbO-Type MOFs

Investigation of the impact of ligand-originated MOF (metal–organic framework) isomerism and ligand functionalization on gas adsorption is of vital importance because a study in this aspect provides valuable guidance for future fabrication of new MOFs exhibiting better performance. For the abovementioned purpose, two NbO-type ligand-originated MOF isomers based on methoxy-functionalized diisophthalate ligands were solvothermally constructed in this work. Their gas adsorption properties toward acetylene, carbon dioxide, and methane were systematically investigated, revealing their promising potential for the adsorptive separation of both acetylene/methane and carbon dioxide/methane gas mixtures, which are involved in the industrial processes of acetylene production and natural gas sweetening. In particular, compared to its isomer <b>ZJNU-58</b>, <b>ZJNU-59</b> displays larger acetylene and carbon dioxide uptake capacities as well as higher acetylene/methane and carbon dioxide/methane adsorption selectivities despite its lower pore volume and surface area, demonstrating a very crucial role that the effect of pore size plays in acetylene and carbon dioxide adsorption. In addition, the impact of ligand modification with a methoxy group on gas adsorption was also evaluated. <b>ZJNU-58</b> exhibits slightly lower acetylene and carbon dioxide uptake capacities but higher acetylene/methane and carbon dioxide/methane adsorption selectivities as compared to its parent compound NOTT-103. By contrast, enhanced adsorption selectivities and uptake capacities were observed for <b>ZJNU-59</b> as compared to its parent compound <b>ZJNU-73</b>. The results demonstrated that the impact of ligand functionalization with a methoxy group on gas adsorption might vary from MOF to MOF, depending on the chosen parent compound. The results might shed some light on understanding the impact of both ligand-originated MOF isomerism and methoxy group functionalization on gas adsorption

Exploring the Effect of Ligand-Originated MOF Isomerism and Methoxy Group Functionalization on Selective Acetylene/Methane and Carbon Dioxide/Methane Adsorption Properties in Two NbO-Type MOFs

Investigation of the impact of ligand-originated MOF (metal–organic framework) isomerism and ligand functionalization on gas adsorption is of vital importance because a study in this aspect provides valuable guidance for future fabrication of new MOFs exhibiting better performance. For the abovementioned purpose, two NbO-type ligand-originated MOF isomers based on methoxy-functionalized diisophthalate ligands were solvothermally constructed in this work. Their gas adsorption properties toward acetylene, carbon dioxide, and methane were systematically investigated, revealing their promising potential for the adsorptive separation of both acetylene/methane and carbon dioxide/methane gas mixtures, which are involved in the industrial processes of acetylene production and natural gas sweetening. In particular, compared to its isomer <b>ZJNU-58</b>, <b>ZJNU-59</b> displays larger acetylene and carbon dioxide uptake capacities as well as higher acetylene/methane and carbon dioxide/methane adsorption selectivities despite its lower pore volume and surface area, demonstrating a very crucial role that the effect of pore size plays in acetylene and carbon dioxide adsorption. In addition, the impact of ligand modification with a methoxy group on gas adsorption was also evaluated. <b>ZJNU-58</b> exhibits slightly lower acetylene and carbon dioxide uptake capacities but higher acetylene/methane and carbon dioxide/methane adsorption selectivities as compared to its parent compound NOTT-103. By contrast, enhanced adsorption selectivities and uptake capacities were observed for <b>ZJNU-59</b> as compared to its parent compound <b>ZJNU-73</b>. The results demonstrated that the impact of ligand functionalization with a methoxy group on gas adsorption might vary from MOF to MOF, depending on the chosen parent compound. The results might shed some light on understanding the impact of both ligand-originated MOF isomerism and methoxy group functionalization on gas adsorption

Highly Ionic Conductive and Transparent Self-Healing Lithium Salt Elastomers Based on Eutectic Strategy

Transparent conductive stretchable liquid-free lithium salt elastomers are well suited for the composition of flexible electronics, as they are not subject to the leakage limitation of ionic gels and the water evaporation of hydrogels. However, the quest for stretchable transparent conductive elastomers with high ionic conductivity remains daunting, as current transparent liquid-free lithium salt elastomers have problems, including their low conductivity (–1 S m–1) and the release of volatile organic compounds (VOCs) due to the evaporation of the organic solvents during the preparation process. Herein, a new type of transparent, stretchable, self-healing, and ultrahigh ionic conductive liquid-free lithium salt elastomers (LSEs) was produced by adjusting the ratio of two types of lithium salt-type polymerizable deep eutectic solvent (Li-PDES) monomers (lithium salt-type polymerizable deep eutectic solvent monomers) and the rapid photoinitiated copolymerization of mixed Li-PDES monomers. One of the LSEs exhibits the highest ionic conductivity (1.43 S m–1) of all liquid-free lithium salt elastomers reported to date. Owing to their excellent ionic conductivity and simple preparation process, we believe that LSEs with transparency (92.1% at 600 nm) and self-healing capability (91.02% for 48 h at 70 °C) should be more deeply investigated and applied in the field of flexible electronics and energy

DataSheet1_A smart nanoplatform for enhanced photo-ferrotherapy of hepatocellular carcinoma.pdf

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Emerging therapies, such as ferroptosis mediated cancer therapy and phototherapy, offer new opportunities for HCC treatment. The combination of multiple treatments is often more effective than monotherapy, but many of the current treatments are prone to serious side effects, resulting in a serious decline in patients’ quality of life. Therefore, the combination therapy of tumor in situ controllable activation will improve the efficacy and reduce side effects for precise treatment of tumor. Herein, we synthesized a GSH-activatable nanomedicine to synergize photothermal therapy (PTT) and ferrotherapy. We utilized a near-infrared dye SQ890 as both an iron-chelating and a photothermal converter agent, which was encapsulated with a GSH-sensitive polymer (PLGA-SS-mPEG), to attain the biocompatible SQ890@Fe nanoparticles (NPs). In the tumor microenvironment (TME), SQ890@Fe NPs showed a GSH-activated photothermal effect that could increase the Fenton reaction rate. Meanwhile, the depletion of GSH could further increase ferroptosis effect. In turn, the increasing radical generated by ferrotherapy could impair the formation of heat shock proteins (HSPs) which could amplify PTT effects by limiting the self-protection mechanism. Overall, the intelligent nanomedicine SQ890@Fe NPs combines ferrotherapy and PTT to enhance the efficacy and safety of cancer treatment through the mutual promotion of the two treatment mechanisms, providing a new dimension for tumor combination therapy.</p

Engineering Biocompatible Hydrogels from Bicomponent Natural Nanofibers for Anticancer Drug Delivery

Natural hydrogels have attracted extensive research interest and shown great potential for many biomedical applications. In this study, a series of biocompatible hydrogels was reported based on the self-assembly of positively charged partially deacetylated α-chitin nanofibers (α-DECHN) and negatively charged 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCNF) for anticancer drug delivery. The formation mechanisms of the α-DECHN/TOCNF hydrogels with different mixing proportions were studied, and their morphological, mechanical, and swelling properties were comprehensively investigated. Additionally, the drug delivery performance of the hydrogels was compared via sustained release test of an anticancer drug (5-fluorouracil). The results showed that the hydrogel with higher physical cross-linking degree exhibited a higher drug loading efficiency and drug release percentage

Hepatoprotective phenylethanoid glycosides from <i>Cirsium setosum</i>

<p>Two new phenylethanoid glycosides, namely <i>β</i>-D-glucopyranoside, 1″-<i>O</i>-(7<i>S</i>)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-<i>α</i>-L-rhamnopyranosyl-4″-[(8<i>E</i>)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (<b>1</b>) and <i>β</i>-D-glucopyranoside, 1″-<i>O</i>-(7<i>S</i>)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-<i>α</i>-L-rhamnopyranosyl-4″-[(8<i>E</i>)-7-(4-hydroxyphenyl)-8-propenoate] (<b>2</b>), together with six phenylethanoid glycosides were isolated from <i>Cirsium setosum</i>. Their structures were elucidated by their spectroscopic data and references. Compounds <b>2</b>, <b>4</b>, <b>5</b>, <b>7</b> and <b>8</b> (10 μM) exhibited moderate hepatoprotective activities. Compounds (<b>3–8</b>) were obtained from this plant for the first time.</p

Qualitative and Quantitative Expression Status of the Human Chromosome 20 Genes in Cancer Tissues and the Representative Cell Lines

Under the guidance of the Chromosome-centric Human Proteome Project (C-HPP),, we conducted a systematic survey of the expression status of genes located at human chromosome 20 (Chr.20) in three cancer tissues, gastric, colon, and liver carcinoma, and their representative cell lines. We have globally profiled proteomes in these samples with combined technology of LC–MS/MS and acquired the corresponding mRNA information upon RNA-seq and RNAchip. In total, 323 unique proteins were identified, covering 60% of the coding genes (323/547) in Chr.20. With regards to qualitative information of proteomics, we overall evaluated the correlation of the identified Chr.20 proteins with target genes of transcription factors or of microRNA, conserved genes and cancer-related genes. As for quantitative information, the expression abundances of Chr.20 genes were found to be almost consistent in both tissues and cell lines of mRNA in all individual chromosome regions, whereas those of Chr.20 proteins in cells are different from tissues, especially in the region of 20q13.33. Furthermore, the abundances of Chr.20 proteins were hierarchically evaluated according to tissue- or cancer-related distribution. The analysis revealed several cancer-related proteins in Chr.20 are tissue- or cell-type dependent. With integration of all the acquired data, for the first time we established a solid database of the Chr.20 proteome