Race-gender specific geographic distribution of the Common Factor.

<p>USA. 1999–2006.</p

Factor loading and alpha-reliability from principal components analysis.

<p>Factor loading and alpha-reliability from principal components analysis.</p

ErGeN trans-band locations.

<p>ErGeN trans-band locations.</p

Saline vs ethanol S-score paraclique networks.

<p>(<b>A</b>) Distribution of S-score network sizes based on the number of genes assigned to each. Significantly ethanol-responsive genes were over-represented in a subset of these networks (red bars). (<b>B</b>) These 16 paracliques were considered ethanol-responsive gene-enriched networks (<i>ErGeNs</i>). (<b>C</b>) Network-based clustering of the 1,246 significantly ethanol-responsive genes in the PFC revealed distinct modules largely corresponding to the ErGeNs depicted in B.</p

Candidate genes in ErGeN trans-band support intervals.

<p>Differential expression q-values and network parameters defined in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033575#s2" target="_blank">Methods</a>.</p>a<p>Connectivity;</p>b<p>Non-synonymous SNPs.</p

ErGeN trans-bands have distinct phenotypic correlations.

<p>Correlations between principal component traits of ErGeN trans-bands and BXD phenotypes (p-value<0.01). Edge thickness indicates strength of network/phenotype association and dashed lines indicate a negative correlation. Each phenotype node is labeled with a trait ID that can be queried on GeneNetwork.</p

Race-gender-specific correlations between age-adjusted (25 to 64 years) mortality from selected causes of death and race-specific infant mortality (zero order) for non-Hispanics in 416 US Central and Fringe Metropolitan Counties, 1999–2010.

<p>*** = p<0.001; * = p<0.05.</p><p>Race-gender-specific correlations between age-adjusted (25 to 64 years) mortality from selected causes of death and race-specific infant mortality (zero order) for non-Hispanics in 416 US Central and Fringe Metropolitan Counties, 1999–2010.</p

Genetic regulatory architecture of major ErGeNs.

<p>Histogram of saline vs ethanol S-score eQTL (genome-wide p-value<0.63) frequencies across the genome divided into 10 megabase (Mb) bins.</p

Hub genes within ErGeN3.

<p>Network visualization of all genes comprising ErGeN3 that share at least one adjacent edge at a correlation threshold of >|0.9|. Node color indicates the magnitude of a gene's transcriptional response to ethanol, quantified using Fisher's combined p-values. Grey nodes were not altered by ethanol. Node size represents a genes degree of connectivity.</p

Expression QTL mapping results for saline RMA and S-score datasets.

<p>P-value thresholds are genome-wide corrected with cutoff values defined as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033575#s2" target="_blank">Methods</a>.</p